scholarly journals HLA–DPB1 and DPB2 are genetic loci for systemic sclerosis: A genome-wide association study in Koreans with replication in North Americans

2009 ◽  
Vol 60 (12) ◽  
pp. 3807-3814 ◽  
Author(s):  
Xiaodong Zhou ◽  
Jong Eun Lee ◽  
Frank C. Arnett ◽  
Momiao Xiong ◽  
Min Young Park ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genetic Loci ◽  
North Americans ◽  
Genome Wide ◽  
A Genome

scholarly journals Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

The Lancet ◽  
2008 ◽  
Vol 372 (9654) ◽  
pp. 1953-1961 ◽  
Author(s):  
Abbas Dehghan ◽  
Anna Köttgen ◽  
Qiong Yang ◽  
Shih-Jen Hwang ◽  
WH Linda Kao ◽  
...  
Keyword(s):  
Uric Acid ◽  
Association Study ◽  
Acid Concentration ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Uric Acid Concentration ◽  
Genetic Loci ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association study identified genetic loci for end-stage liver disease in the Korean population

2020 ◽  
Vol 34 (1) ◽  
pp. S146-S146
Author(s):  
Hye-Mi Jang ◽  
Dong Jin Joo ◽  
Sung Min Kim ◽  
Hyun-Young Park ◽  
Bong-Jo Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Korean Population ◽  
Genetic Loci ◽  
End Stage Liver Disease ◽  
Genome Wide ◽  
A Genome ◽  
End Stage

scholarly journals A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Sven J. van der Lee ◽  
Maria J. Knol ◽  
Ganesh Chauhan ◽  
Claudia L. Satizabal ◽  
Albert Vernon Smith ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genetic Loci ◽  
Brain Volumes ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-Wide Association Study of Diabetogenic Adipose Morphology in the GENetics of Adipocyte Lipolysis (GENiAL) Cohort

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1085
Author(s):  
Veroniqa Lundbäck ◽  
Agné Kulyté ◽  
Peter Arner ◽  
Rona J. Strawbridge ◽  
Ingrid Dahlman
Keyword(s):  
Association Study ◽  
Candidate Genes ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Functional Evaluation ◽  
Small Interfering Rnas ◽  
Genetic Loci ◽  
Fat Depots ◽  
Genome Wide ◽  
A Genome

An increased adipocyte size relative to the size of fat depots, also denoted hypertrophic adipose morphology, is a strong risk factor for the future development of insulin resistance and type 2 diabetes. The regulation of adipose morphology is poorly understood. We set out to identify genetic loci associated with adipose morphology and functionally evaluate candidate genes for impact on adipocyte development. We performed a genome-wide association study (GWAS) in the unique GENetics of Adipocyte Lipolysis (GENiAL) cohort comprising 948 participants who have undergone abdominal subcutaneous adipose biopsy with a determination of average adipose volume and morphology. The GWAS identified 31 genetic loci displaying suggestive association with adipose morphology. Functional evaluation of candidate genes by small interfering RNAs (siRNA)-mediated knockdown in adipose-derived precursor cells identified six genes controlling adipocyte renewal and differentiation, and thus of potential importance for adipose hypertrophy. In conclusion, genetic and functional studies implicate a regulatory role for ATL2, ARHGEF10, CYP1B1, TMEM200A, C17orf51, and L3MBTL3 in adipose morphology by their impact on adipogenesis.

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