MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study

Clarissa E. Vergunst; Danielle M. Gerlag; Lisa von Moltke; Michael Karol; Tim Wyant; Xuedong Chi; Ellen Matzkin; Timothy Leach; Paul P. Tak

doi:10.1002/art.24978

MLN3897 plus methotrexate in patients with rheumatoid arthritis: Safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study

Arthritis & Rheumatism ◽

10.1002/art.24978 ◽

2009 ◽

Vol 60 (12) ◽

pp. 3572-3581 ◽

Cited By ~ 54

Author(s):

Clarissa E. Vergunst ◽

Danielle M. Gerlag ◽

Lisa von Moltke ◽

Michael Karol ◽

Tim Wyant ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Proof Of Concept ◽

Pharmacokinetics And Pharmacodynamics ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study ◽

Ccr1 Antagonist

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Faculty Opinions recommendation of LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.724435768.793505748 ◽

2015 ◽

Author(s):

Vijay Kuchroo

Keyword(s):

Rheumatoid Arthritis ◽

Monoclonal Antibody ◽

Phase I ◽

Interleukin 17 ◽

Proof Of Concept ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study

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LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

Arthritis & Rheumatism ◽

10.1002/art.27334 ◽

2010 ◽

Vol 62 (4) ◽

pp. 929-939 ◽

Cited By ~ 341

Author(s):

M. C. Genovese ◽

F. Van den Bosch ◽

S. A. Roberson ◽

S. Bojin ◽

I. M. Biagini ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Monoclonal Antibody ◽

Phase I ◽

Interleukin 17 ◽

Proof Of Concept ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study

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Faculty Opinions recommendation of Randomized, double-blind, placebo-controlled, proof-of-concept study of the cortical spreading depression inhibiting agent tonabersat in migraine prophylaxis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1161355.621864 ◽

2009 ◽

Author(s):

David Dodick ◽

Todd Schwedt

Keyword(s):

Cortical Spreading Depression ◽

Spreading Depression ◽

Migraine Prophylaxis ◽

Proof Of Concept ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study

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A randomized, double-blind, placebo-controlled proof of concept study to evaluate samidorphan in the prevention of olanzapine-induced weight gain in healthy volunteers

Schizophrenia Research ◽

10.1016/j.schres.2017.10.014 ◽

2018 ◽

Vol 195 ◽

pp. 245-251 ◽

Cited By ~ 16

Author(s):

Bernard L. Silverman ◽

William Martin ◽

Asli Memisoglu ◽

Lauren DiPetrillo ◽

Christoph U. Correll ◽

...

Keyword(s):

Weight Gain ◽

Healthy Volunteers ◽

Proof Of Concept ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study

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A multi-centre, double-blind, placebo-controlled, multiple-dose crossover proof of concept study to compare the efficacy of mefenamic acid administered vaginally and orally in healthy menstruating women with primary dysmenorrhoea requiring analgesia

http://isrctn.org/> ◽

10.1186/isrctn32847177 ◽

2012 ◽

Author(s):

David Bell

Keyword(s):

Mefenamic Acid ◽

Multiple Dose ◽

Proof Of Concept ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study ◽

Primary Dysmenorrhoea ◽

Menstruating Women

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Escitalopram for Severe Asthma and Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Proof-of-Concept Study

Psychosomatics ◽

10.1016/j.psym.2011.07.009 ◽

2012 ◽

Vol 53 (1) ◽

pp. 75-80 ◽

Cited By ~ 19

Author(s):

E. Sherwood Brown ◽

Christina Howard ◽

David A. Khan ◽

Thomas J. Carmody

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Severe Asthma ◽

Proof Of Concept ◽

Major Depressive ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study

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THU0109 Lack of Efficacy of CCR1 Antagonist BMS-817399 in Patients with Moderate to Severe Rheumatoid Arthritis: Results of 12-Week Proof-Of-Concept Study

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.3871 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 215.1-215 ◽

Cited By ~ 4

Author(s):

A. Kivitz ◽

P. Maciag ◽

P. Gulati ◽

S. Du ◽

S.E. Connolly ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Proof Of Concept ◽

Severe Rheumatoid Arthritis ◽

Concept Study ◽

Ccr1 Antagonist

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The AMPK modulator metformin as adjunct to methotrexate in patients with rheumatoid arthritis: A proof-of-concept, randomized, double-blind, placebo-controlled trial

International Immunopharmacology ◽

10.1016/j.intimp.2021.107575 ◽

2021 ◽

Vol 95 ◽

pp. 107575

Author(s):

Mahmoud S. Abdallah ◽

Sumaiah J. Alarfaj ◽

Dalia S. Saif ◽

Mostafa E. EL-Naggar ◽

Mohamed A. Elsokary ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Controlled Trial ◽

Proof Of Concept ◽

Double Blind ◽

Double Blind Placebo

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OP0047 A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Proof-Of-Concept Study to Evaluate the Efficacy and Safety of Sirukumab in Patients with Active Lupus Nephritis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.3974 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 78.2-78 ◽

Cited By ~ 7

Author(s):

R. van Vollenhoven ◽

C. Aranow ◽

B. Rovin ◽

C. Wagner ◽

B. Zhou ◽

...

Keyword(s):

Lupus Nephritis ◽

Phase 2 ◽

Proof Of Concept ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study ◽

Active Lupus Nephritis ◽

Active Lupus

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Effect of Denosumab on Osteolytic Lesion Activity after Total Hip Arthroplasty: A Single-Centre, Randomised, Double-Blind, Placebo-Controlled, Proof-of-Concept Study

SSRN Electronic Journal ◽

10.2139/ssrn.3679988 ◽

2020 ◽

Author(s):

Mohit Mahatma ◽

Raveen Jayasuriya ◽

David Hughes ◽

Nigel Hoggard ◽

Simon Buckley ◽

...

Keyword(s):

Total Hip Arthroplasty ◽

Hip Arthroplasty ◽

Osteolytic Lesion ◽

Proof Of Concept ◽

Single Centre ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study ◽

Total Hip

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