CTLA4/ICOSgene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population

2009 ◽  
Vol 60 (4) ◽  
pp. 931-937 ◽  
Author(s):  
Erin J. Walker ◽  
Gideon M. Hirschfield ◽  
Chun Xu ◽  
Yan Lu ◽  
Xiangdong Liu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Canadian Population

scholarly journals A case of syndrome overlapping primary biliary cirrhosis and lupoid hepatitis complicated by rheumatoid arthritis, Sjoegren's syndrome and CRST syndrome.

Kanzo ◽  
1998 ◽  
Vol 39 (10) ◽  
pp. 738-744
Author(s):  
Susumu IMOTO ◽  
Soo Ryang KIM ◽  
Yasuni NAKANUMA ◽  
Katsuhisa OMAGARI ◽  
Hideki KINOSHITA
Keyword(s):  
Rheumatoid Arthritis ◽  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Lupoid Hepatitis ◽  
Sjoegren’S Syndrome ◽  
Crst Syndrome

scholarly journals A case of rheumatoid arthritis with chronic thyroiditis, primary biliary cirrhosis, and anti-centromere antibody.

1989 ◽  
Vol 78 (3) ◽  
pp. 393-397 ◽  
Author(s):  
Manabu HASHIMOTO ◽  
Yoshinari TAKASAKI ◽  
Jun SHIOTA ◽  
Hiroshi HASHIMOTO ◽  
Shun-ichi HIROSE ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Chronic Thyroiditis

scholarly journals Rheumatoid Arthritis and Primary Biliary Cirrhosis: Cause, Consequence, or Coincidence?

Arthritis ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Daniel S. Smyk ◽  
Dimitrios P. Bogdanos ◽  
Maria G. Mytilinaiou ◽  
Andrew K. Burroughs ◽  
Eirini I. Rigopoulou
Keyword(s):  
Rheumatoid Arthritis ◽  
Primary Biliary Cirrhosis ◽  
High Titre ◽  
Cholestatic Liver Disease ◽  
Biliary Cirrhosis ◽  
Infectious Agents ◽  
Antimitochondrial Antibodies ◽  
Genetic Studies ◽  
Genetic Traits ◽  
Large Case

Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized serologically by cholestasis and the presence of high-titre antimitochondrial antibodies and histologically by chronic nonsuppurative cholangitis and granulomata. PBC patients often have concomitant autoimmune diseases, including arthropathies. This raises the question as to whether there are shared features in the pathogenesis of those diseases with the pathogenesis of PBC. Epidemiological and large case studies have indicated that although the incidence of rheumatoid arthritis (RA) is not significantly raised in PBC patients, there appears to be a higher rate of RA in PBC patients and their relatives. Genetic studies have demonstrated that several genes implicated in PBC have also been implicated in RA. Epigenetic studies provided a wealth of data regarding RA, but the findings on epigenetic changes in PBC are very limited. As well, certain infectious agents identified in the pathogenesis of PBC may also play a role in the pathogenesis of RA. These data suggest that although RA is not significantly present in PBC, some individuals with certain genetic traits and environmental exposures may develop both conditions. This concept may also apply to other concomitant diseases found in PBC patients.

Seven Different Assays of Hyaluronan Compared for Clinical Utility

1992 ◽  
Vol 38 (1) ◽  
pp. 127-132 ◽  
Author(s):  
Ulla Lindqvist ◽  
Kenji Chichibu ◽  
Bertrand Delpech ◽  
Ronald L Goldberg ◽  
Warren Knudson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Primary Biliary Cirrhosis ◽  
Clinical Utility ◽  
High Specificity ◽  
The Other ◽  
Healthy Population ◽  
Biliary Cirrhosis ◽  
Specificity And Sensitivity ◽  
Clinical Investigations ◽  
Healthy Persons

Abstract To compare six assays of hyaluronan (hyaluronic acid; HYA) in serum, developed in different laboratories, we analyzed 10 samples from each of three groups: healthy persons, patients with primary biliary cirrhosis, and patients with rheumatoid arthritis. All the assays are based on the use of affinity proteins specific for HYA, prepared from cartilage or brain tissue, and are analogous to RIA or enzyme immunoassay techniques. The assay results were of the same magnitude. Although statistical analysis indicated that the methods in some cases deviated significantly from one another, this variation was less than the physiological variation in the healthy population. Therefore, the results of clinical investigations in which the various methods have been used are comparable. The analyses have high specificity and sensitivity for primary biliary cirrhosis but are somewhat less suitable for detecting rheumatoid arthritis. A seventh laboratory, which obtained antibodies to HYA, used these in an RIA to analyze a separate series of serum specimens. Results were in agreement with those obtained by one of the other assays.

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