scholarly journals Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus

2009 ◽  
Vol 60 (1) ◽  
pp. 207-218 ◽  
Author(s):  
George K. Bertsias ◽  
Magda Nakou ◽  
Christianna Choulaki ◽  
Amalia Raptopoulou ◽  
Eva Papadimitraki ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Immunohistochemical Analysis ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Programmed Death 1

scholarly journals Programmed death 1 (PD-1) serum level and gene expression in recent onset systemic lupus erythematosus patients

2021 ◽  
Vol 43 (3) ◽  
pp. 213-218
Author(s):  
Sherine A. Bassiouni ◽  
Hanaa M. Abdeen ◽  
Heba K. Morsi ◽  
Maysaa E. Zaki ◽  
Maha Abdelsalam ◽  
...  
Keyword(s):  
Gene Expression ◽  
Systemic Lupus Erythematosus ◽  
Serum Level ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Recent Onset ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Onset Systemic Lupus Erythematosus

Programmed Death-1 Gene Polymorphisms in Patients With Systemic Lupus Erythematosus in Taiwan

2006 ◽  
Vol 26 (6) ◽  
pp. 506-511 ◽  
Author(s):  
SHU-CHEN WANG ◽  
YI-JING CHEN ◽  
TSAN-TENG OU ◽  
CHENG-CHIN WU ◽  
WEN-CHAN TSAI ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Gene Polymorphisms ◽  
Systemic Lupus ◽  
Programmed Death ◽  
Programmed Death 1

The Systemic Activation of Programmed Death 1-PD-L1 Axis Protects Systemic Lupus Erythematosus Model from Nephritis

2017 ◽  
Vol 46 (5) ◽  
pp. 371-379 ◽  
Author(s):  
Wenjun Liao ◽  
Hua Zheng ◽  
Sha Wu ◽  
Yanmei Zhang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
B Cells ◽  
Lupus Erythematosus ◽  
Enzyme Linked Immunosorbent Assay ◽  
Systemic Lupus ◽  
Activated T Cells ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Ifn Γ

Background: Systemic lupus erythematosus (SLE) is characterized by abnormal activated T cells, autoreactive B cells, and massive cytokines. The CD4+ T cells determined B-cells differentiation and cytokines production. The programmed death 1 (PD-1) is the checkpoint immunoinhibitory receptor of activated T cells, and its engagement could exhaust T cells. In this study, we investigated the role of PD-1 systemic engagement with PD-L1-Ig in lupus-like nephritis in SLE mice. Methods: The murine PD-L1-Ig was injected into SLE-prone mice. The proteinuria and survival ratio were monitored. The production of anti-dsDNA autoantibodies and cytokines in serum were measured by enzyme-linked immunosorbent assay. The cytokine-producing T cells (interferon-γ, IFN-γ and IL-17α) in kidney and spleen were detected with flowcytometry. The pathological evaluation of the Ig deposition in the glomeruliand was determined with immunofluorescence. Lymphocytes in 24-h urine were detected with flowcytometry. Results: The systemic administration of PD-L1-Ig activated PD-1-PD-L1 axis of CD4+ T lymphocytes, suppressed Th17 formation in many organs, including the spleen and the kidney, demolished abnormal production of cytokines (IFN-γ, IL-17, and IL-10) and anti-dsDNA autoantibodies in serum, inhibited immunoglobulin G deposition in the glomeruli with the decrease of proteinuria, and activated T cells in urine. Accordingly, the systemic conjugation of PD-L1-PD-1 impaired renal autoimmune injure and prolonged survival time. Conclusion: Our research demonstrated that the protective function of systemic activation of PD-1-PD-L1 axis with PD-L1-Ig attenuates the nephritis in SLE-prone mice, which facilitates us to understand the suppressive function of PD-1-PD-L1 axis in the pathogenesis and progress of the lupus nephritis, and to explore a possible effective therapeutic strategy to SLE.

scholarly journals Lower expression levels of the programmed death 1 receptor on CD4+CD25+ T cells and correlation with the PD-1.3A genotype in patients with systemic lupus erythematosus

2010 ◽  
Vol 62 (6) ◽  
pp. 1702-1711 ◽  
Author(s):  
Helga Kristjansdottir ◽  
Kristjan Steinsson ◽  
Iva Gunnarsson ◽  
Gerdur Gröndal ◽  
Kristjan Erlendsson ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Expression Levels ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Lower Expression
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