Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue

2007 ◽  
Vol 56 (7) ◽  
pp. 2180-2191 ◽  
Author(s):  
J. Ludikhuize ◽  
D. de Launay ◽  
D. Groot ◽  
T. J. M. Smeets ◽  
M. Vinkenoog ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Family Member ◽  
Synovial Tissue ◽  
Forkhead Box ◽  
Rheumatoid Synovial Tissue

The role of Forkhead Box O 3a (FoxO3a) Transcription Factors in the Pathogenesis of Pulmonary Fibrosis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
HM Al-Tamari ◽  
M Eschenhagen ◽  
A Schmall ◽  
R Savai ◽  
HA Ghofrani ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Pulmonary Fibrosis ◽  
Forkhead Box

Appearance of Anti-HLA-DR-Reactive Cells in Normal and Rheumatoid Synovial Tissue

1981 ◽  
Vol 14 (2) ◽  
pp. 183-192 ◽  
Author(s):  
L. KLARESKOG ◽  
U. FORSUM ◽  
U. MALMNAS TJERNLUND ◽  
D. KABELITZ ◽  
A. WIGREN
Keyword(s):  
Synovial Tissue ◽  
Hla Dr ◽  
Rheumatoid Synovial Tissue

scholarly journals Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue

2001 ◽  
Vol 44 (9) ◽  
pp. 2046-2054 ◽  
Author(s):  
Beate B. B�hm ◽  
Thomas Aigner ◽  
Carl P. Blobel ◽  
Joachim R. Kalden ◽  
Harald Burkhardt
Keyword(s):  
Synovial Tissue ◽  
Rheumatoid Synovial Tissue ◽  
Enhanced Expression

scholarly journals Regulation of Wnt Signaling by FOX Transcription Factors in Cancer

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3446
Author(s):  
Stefan Koch
Keyword(s):  
Transcription Factors ◽  
Wnt Signaling ◽  
Wnt Pathway ◽  
Treatment Options ◽  
Wnt Signaling Pathway ◽  
Tissue Homeostasis ◽  
Fine Tuning ◽  
Dependent Manner ◽  
Forkhead Box ◽  
Signaling Activity

Aberrant activation of the oncogenic Wnt signaling pathway is a hallmark of numerous types of cancer. However, in many cases, it is unclear how a chronically high Wnt signaling tone is maintained in the absence of activating pathway mutations. Forkhead box (FOX) family transcription factors are key regulators of embryonic development and tissue homeostasis, and there is mounting evidence that they act in part by fine-tuning the Wnt signaling output in a tissue-specific and context-dependent manner. Here, I review the diverse ways in which FOX transcription factors interact with the Wnt pathway, and how the ectopic reactivation of FOX proteins may affect Wnt signaling activity in various types of cancer. Many FOX transcription factors are partially functionally redundant and exhibit a highly restricted expression pattern, especially in adults. Thus, precision targeting of individual FOX proteins may lead to safe treatment options for Wnt-dependent cancers.

Localization of human glucocorticoid receptor in rheumatoid synovial tissue of the knee joint

2005 ◽  
Vol 34 (6) ◽  
pp. 426-432 ◽  
Author(s):  
C. T. Tohyama ◽  
M. Yamakawa ◽  
A. Murasawa ◽  
K. Nakazono ◽  
H. Ishikawa
Keyword(s):  
Knee Joint ◽  
Glucocorticoid Receptor ◽  
Synovial Tissue ◽  
Rheumatoid Synovial Tissue

Transcription Factors: Forkhead Box (FOX)

2020 ◽  
Author(s):  
Vladimir V. Kalinichenko ◽  
Craig S. Bolte ◽  
Tanya V. Kalin
Keyword(s):  
Transcription Factors ◽  
Forkhead Box

scholarly journals FOXO Transcriptional Factors and Long-Term Living

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ghulam Murtaza ◽  
Abida Kalsoom Khan ◽  
Rehana Rashid ◽  
Saiqa Muneer ◽  
Syed Muhammad Farid Hasan ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Healthy Aging ◽  
Growth Stress ◽  
Human Longevity ◽  
Growth Factor Signaling ◽  
Forkhead Box ◽  
Foxo Transcription Factors ◽  
Genetic And Environmental Factors

Several pathologies such as neurodegeneration and cancer are associated with aging, which is affected by many genetic and environmental factors. Healthy aging conceives human longevity, possibly due to carrying the defensive genes. For instance, FOXO (forkhead box O) genes determine human longevity. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. Only one FOXO gene (FOXO DAF-16) exists in invertebrates, while four FOXO genes, that is, FOXO1, FOXO3, FOXO4, and FOXO6 are found in mammals. These four transcription factors are involved in the multiple cellular pathways, which regulate growth, stress resistance, metabolism, cellular differentiation, and apoptosis in mammals. However, the accurate mode of longevity by FOXO factors is unclear until now. This article describes briefly the existing knowledge that is related to the role of FOXO factors in human longevity.

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