scholarly journals Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: An in vitro study

2006 ◽  
Vol 56 (1) ◽  
pp. 199-207 ◽  
Author(s):  
Nathalie W. D. Jansen ◽  
Goris Roosendaal ◽  
Johannes W. J. Bijlsma ◽  
Jeroen DeGroot ◽  
Floris P. J. G. Lafeber
Keyword(s):  
Cartilage Damage ◽  
In Vitro Study ◽  
Vitro Study ◽  
Cartilage Tissue ◽  
Human Cartilage ◽  
Low Concentrations ◽  
Short Period

Low concentrations of glyphosate alone affect the pubertal male rat meiotic step: An in vitro study

2022 ◽  
Vol 79 ◽  
pp. 105291
Author(s):  
Blondet Antonine ◽  
Martin Guillaume ◽  
Durand Philippe ◽  
Perrard Marie-Hélène
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Male Rat ◽  
Low Concentrations

Fiberoptic microindentation technique for early osteoarthritis diagnosis: an in vitro study on human cartilage

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
G. Marchi ◽  
P. Foehr ◽  
S. Consalvo ◽  
A. Javadzadeh-Kalarhodi ◽  
J. Lang ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Early Osteoarthritis ◽  
Human Cartilage ◽  
Microindentation Technique

scholarly journals Kartogenin Enhances Chondrogenic Differentiation of MSCs in 3D Tri-Copolymer Scaffolds and the Self-Designed Bioreactor System

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 115
Author(s):  
Ching-Yun Chen ◽  
Chunching Li ◽  
Cherng-Jyh Ke ◽  
Jui-Sheng Sun ◽  
Feng-Huei Lin
Keyword(s):  
Tissue Engineering ◽  
Chondrogenic Differentiation ◽  
Cartilage Damage ◽  
Cartilage Tissue Engineering ◽  
3D Culture ◽  
Cartilage Tissue ◽  
Great Promise ◽  
Clinical Consequence ◽  
Human Cartilage

Human cartilage has relatively slow metabolism compared to other normal tissues. Cartilage damage is of great clinical consequence since cartilage has limited intrinsic healing potential. Cartilage tissue engineering is a rapidly emerging field that holds great promise for tissue function repair and artificial/engineered tissue substitutes. However, current clinical therapies for cartilage repair are less than satisfactory and rarely recover full function or return the diseased tissue to its native healthy state. Kartogenin (KGN), a small molecule, can promote chondrocyte differentiation both in vitro and in vivo. The purpose of this research is to optimize the chondrogenic process in mesenchymal stem cell (MSC)-based chondrogenic constructs with KGN for potential use in cartilage tissue engineering. In this study, we demonstrate that KGN treatment can promote MSC condensation and cell cluster formation within a tri-copolymer scaffold. Expression of Acan, Sox9, and Col2a1 was significantly up-regulated in three-dimensional (3D) culture conditions. The lacuna-like structure showed active deposition of type II collagen and aggrecan deposition. We expect these results will open new avenues for the use of small molecules in chondrogenic differentiation protocols in combination with scaffolds, which may yield better strategies for cartilage tissue engineering.

The effect of Lidocaine on the viability of cultivated mature human cartilage cells: an in vitro study

2011 ◽  
Vol 19 (7) ◽  
pp. 1206-1213 ◽  
Author(s):  
Tom F. Jacobs ◽  
Pieter S. Vansintjan ◽  
Nathalie Roels ◽  
Sofie S. Herregods ◽  
Gust Verbruggen ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Human Cartilage ◽  
Cartilage Cells
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