Anti–cyclic citrullinated peptide antibody and rheumatoid factor isotypes in African Americans with early rheumatoid arthritis

2006 ◽  
Vol 54 (9) ◽  
pp. 3057-3059 ◽  
Author(s):  
Ted R. Mikuls ◽  
V. Michael Holers ◽  
Lezlie Parrish ◽  
Kristine A. Kuhn ◽  
Doyt L. Conn ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
African Americans ◽  
Rheumatoid Factor ◽  
Early Rheumatoid Arthritis ◽  
Cyclic Citrullinated Peptide ◽  
Peptide Antibody ◽  
Rheumatoid Factor Isotypes ◽  
Citrullinated Peptide

scholarly journals Diagnostic value of anti-cyclic citrullinated peptide antibody combined with rheumatoid factor in rheumatoid arthritis in Asia: a meta-analysis

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110477
Author(s):  
Xiaochun Yang ◽  
Yue Cai ◽  
Bin Xue ◽  
Bo Zhang
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Likelihood Ratio ◽  
Meta Analysis ◽  
Asian Population ◽  
Diagnostic Value ◽  
Cyclic Citrullinated Peptide ◽  
Peptide Antibody ◽  
Combined Detection ◽  
Citrullinated Peptide

Objective This meta-analysis explored the diagnostic value of anti-cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor (RF) for rheumatoid arthritis (RA) in the Asian population. Methods Embase, Medline, Cochrane Library, Chinese Science and Technology Periodicals, China National Knowledge Infrastructure, and China Wanfang Databases were searched from 1 January 2000 to 1 February 2021 to collect studies on the combined detection of anti-CCP and RF for diagnosing RA. The sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (+LR), and negative likelihood ratio (−LR) were combined and analyzed. Summary receiver operating characteristic (SROC) curves were drawn. Results Twenty-four published papers were analyzed, including 21 combined in series and 8 combined in parallel. In the tandem analysis, the sensitivity = 0.64 [95% confidence interval (CI): 0.58–0.70], specificity = 0.97 (95%CI: 0.95–0.98), +LR = 19.70 (95%CI: 12.74–30.46), −LR = 0.37 (95%CI: 0.31–0.43), DOR = 53.43 (95%CI: 34.46–82.40), and area under the SROC curve = 0.89. In the parallel combination, the sensitivity = 0.87 (95%CI: 0.80–0.92), specificity = 0.76 (95%CI: 0.67–0.84), +LR = 3.68 (95%CI: 2.62–5.17), −LR = 0.17 (95%CI: 0.11–0.26), DOR = 21.56 (95%CI: 11.63–39.99), and area under the SROC curve = 0.89. Conclusion Anti-CCP and RF combined detection improves the diagnostic efficiency of RA, providing a potential strategy for early clinical screening in the Asian population. This trial was retrospectively registered in the INPLASY/Research Registry ( https: //inplasy.com/ ) with the registration number INPLASY202180106.

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