Stem cells and rheumatology: Update on adult stem cell therapy in autoimmune diseases

2006 ◽  
Vol 55 (4) ◽  
pp. 521-525 ◽  
Author(s):  
Alan Tyndall ◽  
Kararina Leblanc
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Autoimmune Diseases ◽  
Stem Cell Therapy ◽  
Adult Stem Cell

scholarly journals Future Implementation of Adult Stem Cell Therapy in the Current Standards of Care for Myocardial Infarction

2008 ◽  
Author(s):  
Paul Bates
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Clinical Trials ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Adult Stem Cells ◽  
Adult Stem Cell ◽  
Left Ventricular ◽  
Chronic Myocardial Infarction

Purpose: Adult stem cells are among the new methods of approaching the treatment of myocardial tissue damage. The purpose of this review is to clarify misconceptions about stem cell therapy efficacy in clinical trials and provide a thorough understanding of adult stem cells as a future treatment for patients with myocardial infarction. Methods: A comprehensive review of literature was performed analyzing and comparing 12 clinical trials involving the treatment of patients with acute and chronic myocardial infarction. Results: Stem cell treatments carry an excellent safety profile with the ease of one-time dosing, and have shown dramatic functional improvements while reducing the recurrence of myocardial infarction and enhancing quality of life. Important changes with adult stem cell treatments include 1) formation of new cardiomyocytes, 2) sufficient and sustained improvements in cardiac output, 3) increased myocardial contractility, 4) decreased infarct zone diameter, 5) increased left ventricular function, 6) increased exercise ability, and 7) increased coronary perfusion secondary to neovascularization. Conclusion: At this time, based on the current clinical evidence, adult stem cell therapy is in a position to be considered as an optional treatment for patients with acute or chronic myocardial infarction. Adult stem cell therapy is still in experimental stages of development and the continued clinical involvement will provide more evidence to the therapeutic effects of the treatment.

scholarly journals Stem cell therapy- An update

2009 ◽  
Vol 4 (2) ◽  
pp. 46-48
Author(s):  
Fazlur Rahman ◽  
Bikash Subedi ◽  
Anisul Awal ◽  
KMHS Sirajul Haque ◽  
Md Abu Siddique ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Culture Media ◽  
Special Functions ◽  
Adult Stem Cell ◽  
Experimental Conditions ◽  
Cord Injury ◽  
Skin Replacement

Stem cells are one of the most fascinating areas of biology today. Stem cells have two important characteristics that distinguish them from other types of cells. First, they are unspecialized cells that renew themselves for long periods through cell division. The second is that under certain physiologic or experimental conditions, they can be induced to become cells with special functions. Stem cells can be obtained from several sources including spare embryos, special purposes embryos, aborted fetus, umbilical cords, adult tissue or organs, cadavers. The procedure of adult stem cell therapy involves several steps including extraction of cells from various sources, separation by surface markers using FACS, growth in specific culture media and injection into target organs. This modern aspect of regenerative or reparative medicine can be applied for cardiac diseases (coronary artery diseases, heart failure, non ischaemic cardiomyopathies), skin replacement, Diabetes, spinal cord injury, neurodegenerative disease like Parkinsonism, stroke. In future, it may become possible the use of stem cells in organ transplantation.    doi:10.3329/uhj.v4i2.2076 University Heart Journal Vol. 4 No. 2 July 2008 p.46-48

scholarly journals Therapeutic angiogenesis by stem cell: new hope for the ischemic limbs

2019 ◽  
Vol 8 (2) ◽  
pp. 40-46
Author(s):  
AKM Mohiuddin ◽  
Raihan Anwar ◽  
Peter Lewis ◽  
BA Sadiq
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Growth Factor ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Critical Limb Ischemia ◽  
Stromal Vascular Fraction ◽  
Adult Stem Cell ◽  
Limb Ischemia

Critical limb ischemia in an intractable condition associated with high level of amputation, leading to low quality of life increase morbidity and mortality. It is often not treated by standard therapeutic modalities. Neoangiogenesis has been proposed as a novel method of treatment of such patients. Vascular Endothelial Growth Factor (VEGF) and Cytokine Fibroblast growth Factor (FGF1) have been shown to elicit neoangiogesis. Stem cells are progenitor cells which can differentiate in vivo into different type of cells. Collateral vessel formation after stem cell therapy. A case of 50 years old male, diabetic, hypertensive with dry gangrene of tip of left ring finger was treated with stem cell therapy after proper counseling. He received the therapy in the form of SVF (Stromal Vascular Fraction) from adipose tissue by local injection in the territory of the affected vessels. Following monitoring parameters were reported, improved wound status, local temperature change, oxygen saturation change in the ischemic zone. Outcome of stem cell therapy in this case including the rest pain disappeared at 14 days and the finger becomes warmed by 5°C in 3 weeks. The gangrenous area healed in 3 months. Amputation was averted. Angiogenesis is a complex process leading to new blood vessels formation. Mesenchymal stem cells (MSCs) are a type of adult stem cell which has an immunomodulatory effect. Stem cell therapy has been used to improve limb Vascularity. Stem Cells are likely to be an important modality to treat critical limb ischemia. CBMJ 2019 July: Vol. 08 No. 02 P: 40-46

Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes

2009 ◽  
Vol 35 (2) ◽  
pp. 85-93 ◽  
Author(s):  
L. Vija ◽  
D. Farge ◽  
J.-F. Gautier ◽  
P. Vexiau ◽  
C. Dumitrache ◽  
...  
Keyword(s):  
Stem Cells ◽  
Type 1 Diabetes ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy

The promises of stem cells: stem cell therapy for movement disorders

2014 ◽  
Vol 20 ◽  
pp. S128-S131 ◽  
Author(s):  
Hideki Mochizuki ◽  
Chi-Jing Choong ◽  
Toru Yasuda
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Movement Disorders

scholarly journals Optimizing Stem Cell Therapy after Ischemic Brain Injury

2020 ◽  
Vol 22 (3) ◽  
pp. 286-305 ◽  
Author(s):  
Shuai Zhang ◽  
Brittany Bolduc Lachance ◽  
Bilal Moiz ◽  
Xiaofeng Jia
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Cardiac Arrest ◽  
Stem Cell ◽  
Brain Injury ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Injury Treatment

Stem cells have been used for regenerative and therapeutic purposes in a variety of diseases. In ischemic brain injury, preclinical studies have been promising, but have failed to translate results to clinical trials. We aimed to explore the application of stem cells after ischemic brain injury by focusing on topics such as delivery routes, regeneration efficacy, adverse effects, and in vivo potential optimization. PUBMED and Web of Science were searched for the latest studies examining stem cell therapy applications in ischemic brain injury, particularly after stroke or cardiac arrest, with a focus on studies addressing delivery optimization, stem cell type comparison, or translational aspects. Other studies providing further understanding or potential contributions to ischemic brain injury treatment were also included. Multiple stem cell types have been investigated in ischemic brain injury treatment, with a strong literature base in the treatment of stroke. Studies have suggested that stem cell administration after ischemic brain injury exerts paracrine effects via growth factor release, blood-brain barrier integrity protection, and allows for exosome release for ischemic injury mitigation. To date, limited studies have investigated these therapeutic mechanisms in the setting of cardiac arrest or therapeutic hypothermia. Several delivery modalities are available, each with limitations regarding invasiveness and safety outcomes. Intranasal delivery presents a potentially improved mechanism, and hypoxic conditioning offers a potential stem cell therapy optimization strategy for ischemic brain injury. The use of stem cells to treat ischemic brain injury in clinical trials is in its early phase; however, increasing preclinical evidence suggests that stem cells can contribute to the down-regulation of inflammatory phenotypes and regeneration following injury. The safety and the tolerability profile of stem cells have been confirmed, and their potent therapeutic effects make them powerful therapeutic agents for ischemic brain injury patients.

scholarly journals Stem cells in the treatment of patients with coronary heart disease. Part I

2011 ◽  
Vol 10 (2) ◽  
pp. 122-128 ◽  
Author(s):  
N. S. Zhukova ◽  
I. I. Staroverov
Keyword(s):  
Stem Cells ◽  
Coronary Heart Disease ◽  
Stem Cell ◽  
Heart Disease ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Myocardial Damage ◽  
Cellular Cardiomyoplasty ◽  
Modern Methods ◽  
Death Causes

Heart failure (HF) is one of the leading death causes in patients with myocardial infarction (MI). The modern methods of reperfusion MI therapy, such as thrombolysis, surgery and balloon revascularization, even when performed early, could fail to prevent the development of large myocardial damage zones, followed by HF. Therefore, the researches have been searching for the methods which improve functional status of damaged myocardium. This review is focused on stem cell therapy, a method aimed at cardiac function restoration. The results of experimental and clinical studies on stem cell therapy in coronary heart disease are presented. Various types of stem cells, used for cellular cardiomyoplasty, are characterised. The methods of cell transplantation into myocardium and potential adverse effects of stem cell therapy are discussed.

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