Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products

2006 ◽  
Vol 54 (9) ◽  
pp. 2901-2911 ◽  
Author(s):  
Raghunatha R. Yammani ◽  
Cathy S. Carlson ◽  
Anne R. Bresnick ◽  
Richard F. Loeser
Keyword(s):  
Matrix Metalloproteinase ◽  
Advanced Glycation End Products ◽  
Articular Chondrocytes ◽  
Human Articular Chondrocytes ◽  
Advanced Glycation ◽  
Matrix Metalloproteinase 13 ◽  
Glycation End Products ◽  
End Products

scholarly journals Chondroprotective effects of purple corn anthocyanins on advanced glycation end products induction through suppression of NF-κB and MAPK signaling

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hathaichanok Chuntakaruk ◽  
Prachya Kongtawelert ◽  
Peraphan Pothacharoen
Keyword(s):  
Advanced Glycation End Products ◽  
Articular Chondrocytes ◽  
Cartilage Degradation ◽  
Mapk Signaling ◽  
Human Articular Chondrocytes ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Purple Corn ◽  
Anti Inflammatory

AbstractFormation of advanced glycation end products (AGEs), which are associated with diabetes mellitus, contributes to prominent features of osteoarthritis, i.e., inflammation-mediated destruction of articular cartilage. Among the phytochemicals which play a role in anti-inflammatory effects, anthocyanins have also been demonstrated to have anti-diabetic properties. Purple corn is a source of three major anthocyanins: cyanidin-3-O-glucoside, pelargonidin-3-O-glucoside and peonidin-3-O-glucoside. Purple corn anthocyanins have been demonstrated to be involved in the reduction of diabetes-associated inflammation, suggesting that they may have a beneficial effect on diabetes-mediated inflammation of cartilage. This investigation of the chondroprotective effects of purple corn extract on cartilage degradation found a reduction in glycosaminoglycans released from AGEs induced cartilage explants, corresponding with diminishing of uronic acid loss of the cartilage matrix. Investigation of the molecular mechanisms in human articular chondrocytes showed the anti-inflammatory effect of purple corn anthocyanins and the metabolite, protocatechuic acid (PCA) on AGEs induced human articular chondrocytes via inactivation of the NFκb and MAPK signaling pathways. This finding suggests that purple corn anthocyanins and PCA may help ameliorate AGEs mediated inflammation and diabetes-mediated cartilage degradation.

scholarly journals Role of advanced glycation end products in cellular signaling

Redox Biology ◽  
2014 ◽  
Vol 2 ◽  
pp. 411-429 ◽  
Author(s):  
Christiane Ott ◽  
Kathleen Jacobs ◽  
Elisa Haucke ◽  
Anne Navarrete Santos ◽  
Tilman Grune ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Cellular Signaling ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

The role of receptor for advanced glycation end products (RAGE) in neuronal differentiation

2012 ◽  
Vol 90 (6) ◽  
pp. 1136-1147 ◽  
Author(s):  
Joanne Kim ◽  
Carthur K. Wan ◽  
Simon J. O'Carroll ◽  
Shamim B. Shaikh ◽  
Louise F.B. Nicholson
Keyword(s):  
Neuronal Differentiation ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products
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