scholarly journals Bone marrow abnormalities on magnetic resonance imaging are associated with type II collagen degradation in knee osteoarthritis: A three-month longitudinal study

2005 ◽  
Vol 52 (9) ◽  
pp. 2822-2829 ◽  
Author(s):  
P. Garnero ◽  
C. Peterfy ◽  
S. Zaim ◽  
M. Schoenharting
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bone Marrow ◽  
Longitudinal Study ◽  
Magnetic Resonance ◽  
Knee Osteoarthritis ◽  
Type Ii Collagen ◽  
Collagen Degradation ◽  
Type Ii ◽  
Resonance Imaging

scholarly journals OMERACT Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS) Assessment in Longitudinal Study

2019 ◽  
Vol 46 (9) ◽  
pp. 1239-1242
Author(s):  
Jacob L. Jaremko ◽  
Robert G.W. Lambert ◽  
Susanne J. Pedersen ◽  
Ulrich Weber ◽  
Duncan Lindsay ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bone Marrow ◽  
Longitudinal Study ◽  
Magnetic Resonance ◽  
Scoring System ◽  
Steroid Injection ◽  
Intraclass Correlation ◽  
Hip Osteoarthritis ◽  
Post Injection ◽  
Resonance Imaging

Objective.To assess reliability, feasibility, and responsiveness of Hip Inflammation Magnetic resonance imaging Scoring System (HIMRISS) for bone marrow lesions (BML) in hip osteoarthritis (OA).Methods.HIMRISS was scored by 8 readers in 360 hips of 90 patients imaged pre/post-hip steroid injection. Pre-scoring, new readers trained online to achieve intraclass correlation coefficient (ICC) > 0.80 versus experts.Results.HIMRISS reliability was excellent for BML status (ICC 0.83–0.92). Despite small changes post-injection, reliability of BML change scores was high in femur (0.76–0.81) and moderate in acetabulum (0.42–0.56).Conclusion.HIMRISS should be a priority for further assessment of hip BML in OA, and evaluated for use in other arthropathies.

scholarly journals New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells

2018 ◽  
Vol 72 (4) ◽  
pp. 207-215
Author(s):  
Valdis Gončars ◽  
Konstantīns Kalnbērzs ◽  
Ēriks Jākobsons ◽  
Ieva Briede ◽  
Kristaps Blūms ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bone Marrow ◽  
Magnetic Resonance ◽  
Knee Osteoarthritis ◽  
Mononuclear Cell ◽  
Mononuclear Cells ◽  
Intraarticular Injection ◽  
Control Group ◽  
Resonance Imaging

Abstract The clinical effects on knee osteoarthritis (OA) symptoms and tissue structure were evaluated after bone marrow-derived mononuclear cell intraarticular injection. A group of 32 patients with 34 knee joints in stage II–III osteoarthritis were treated by intraarticular injection of mononuclear cell suspension. Clinical results were obtained by KOOS (Knee Osteoarthritis Outcome Score) and KSS (Knee Society Score) scores during a 12 months follow-up period. Radiological evaluation was performed using magnetic resonance imaging. A comparison with a control group of 28 patients treated with routinely used three hyaluronic acid intra-articular injections was made. No adverse effects were observed after the bone marrow derived mononuclear cells (BM-MNC) injection. At the end point of the follow up all score results had improved, compared to those at to the starting point. 65% of patients maintained minimal perceptible clinical improvement of the score results. The Whole Organ Magnetic Resonance Imaging Score showed improvement from 44.31 to 42.93 points (p < 0.05) during a 6–7 month period. Comparing score results to the control group, a statistically significant (p < 0.05) improvement in the KOOS pain subscale score at the 6 and 12 months was observed in the mononuclear cell group. BM-MNC injection leads to a decrease of knee OA symptoms and slows changes in structure of the degenerative joint tissue.

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