Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor

2005 ◽  
Vol 52 (10) ◽  
pp. 3020-3029 ◽  
Author(s):  
Timothy R. D. J. Radstake ◽  
Fred C. G. J. Sweep ◽  
Paco Welsing ◽  
Barbara Franke ◽  
Sita H. H. M. Vermeulen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Arthritis Severity ◽  
Functional Variants ◽  
Rheumatoid Arthritis Severity ◽  
Circulating Levels

Structure of macrophage migration inhibitory factor in complex with methotrexate

2021 ◽  
Vol 77 (3) ◽  
pp. 293-299
Author(s):  
Kei Fukushima ◽  
Minoru Furuya ◽  
Takashi Kamimura ◽  
Midori Takimoto-Kamimura
Keyword(s):  
Rheumatoid Arthritis ◽  
Dihydrofolate Reductase ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Molecular Orbital Calculations ◽  
Macrophage Migration ◽  
Affinity Matrix ◽  
Nucleotide Synthesis ◽  
X Ray

Methotrexate (MTX) is an anticancer and anti-rheumatoid arthritis drug that is considered to block nucleotide synthesis and the cell cycle mainly by inhibiting the activity of dihydrofolate reductase (DHFR). Using affinity-matrix technology and X-ray analysis, the present study shows that MTX also interacts with macrophage migration inhibitory factor (MIF). Fragment molecular-orbital calculations quantified the interaction between MTX and MIF based on the structure of the complex and revealed the amino acids that are effective in the interaction of MTX and MIF. It should be possible to design new small-molecule compounds that have strong inhibitory activity towards both MIF and DHFR by structure-based drug discovery.

Serum levels of macrophage migration inhibitory factor are associated with rheumatoid arthritis course

2011 ◽  
Vol 32 (8) ◽  
pp. 2307-2311 ◽  
Author(s):  
Mara Anaís Llamas-Covarrubias ◽  
Yeminia Valle ◽  
Rosa Elena Navarro-Hernández ◽  
Iris Paola Guzmán-Guzmán ◽  
María Guadalupe Ramírez-Dueñas ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Serum Levels ◽  
Inhibitory Factor ◽  
Macrophage Migration
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