scholarly journals Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblasts

2005 ◽  
Vol 52 (7) ◽  
pp. 2010-2014 ◽  
Author(s):  
Edita Rutkauskaite ◽  
Dagmar Volkmer ◽  
Yukio Shigeyama ◽  
Jörg Schedel ◽  
Geza Pap ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Transfer ◽  
Matrix Metalloproteinase ◽  
Synovial Fibroblasts ◽  
Retroviral Gene Transfer ◽  
Membrane Type ◽  
Antisense Construct

scholarly journals Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis

2009 ◽  
Vol 60 (3) ◽  
pp. 686-697 ◽  
Author(s):  
Mary-Clare Miller ◽  
Hugh B. Manning ◽  
Abhilash Jain ◽  
Linda Troeberg ◽  
Jayesh Dudhia ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Human Rheumatoid Arthritis ◽  
Membrane Type

scholarly journals Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing

2005 ◽  
Vol 280 (28) ◽  
pp. 26160-26168 ◽  
Author(s):  
Pamela Osenkowski ◽  
Samy O. Meroueh ◽  
Dumitru Pavel ◽  
Shahriar Mobashery ◽  
Rafael Fridman
Keyword(s):  
Matrix Metalloproteinase ◽  
Hinge Region ◽  
Membrane Type

4-Methylumbelliferone induces the expression of membrane type 1-matrix metalloproteinase in cultured human skin fibroblasts

2002 ◽  
Vol 298 (5) ◽  
pp. 646-650 ◽  
Author(s):  
Toshiya Nakamura ◽  
Takashi Ishikawa ◽  
Naoki Nanashima ◽  
Tomisato Miura ◽  
Hiroyuki Nozaka ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Membrane Type

scholarly journals Piezo1 mediates angiogenesis through activation of MT1-MMP signaling

2019 ◽  
Vol 316 (1) ◽  
pp. C92-C103 ◽  
Author(s):  
Hojin Kang ◽  
Zhigang Hong ◽  
Ming Zhong ◽  
Jennifer Klomp ◽  
Kayla J. Bayless ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Sprouting Angiogenesis ◽  
Sphingosine 1 Phosphate ◽  
Wall Shear ◽  
Membrane Type

Angiogenesis is initiated in response to a variety of external cues, including mechanical and biochemical stimuli; however, the underlying signaling mechanisms remain unclear. Here, we investigated the proangiogenic role of the endothelial mechanosensor Piezo1. Genetic deletion and pharmacological inhibition of Piezo1 reduced endothelial sprouting and lumen formation induced by wall shear stress and proangiogenic mediator sphingosine 1-phosphate, whereas Piezo1 activation by selective Piezo1 activator Yoda1 enhanced sprouting angiogenesis. Similarly to wall shear stress, sphingosine 1-phosphate functioned by activating the Ca2+ gating function of Piezo1, which in turn signaled the activation of the matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase during sprouting angiogenesis. Studies in mice in which Piezo1 was conditionally deleted in endothelial cells demonstrated the requisite role of sphingosine 1-phosphate-dependent activation of Piezo1 in mediating angiogenesis in vivo. These results taken together suggest that both mechanical and biochemical stimuli trigger Piezo1-mediated Ca2+ influx and thereby activate matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase and synergistically facilitate sprouting angiogenesis.

scholarly journals Induction of membrane-type-1 matrix metalloproteinase by epidermal growth factor-mediated signaling in gliomas

2004 ◽  
Vol 6 (3) ◽  
pp. 188-199 ◽  
Author(s):  
Timothy E. Van Meter ◽  
William C. Broaddus ◽  
Harcharan K. Rooprai ◽  
Geoffrey J. Pilkington ◽  
Helen L. Fillmore
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Matrix Metalloproteinase ◽  
Epidermal Growth ◽  
Membrane Type
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