scholarly journals A two-year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis

2005 ◽  
Vol 52 (3) ◽  
pp. 833-840 ◽  
Author(s):  
Gunhild Lien ◽  
Anne M. Selvaag ◽  
Berit Flatø ◽  
Margaretha Haugen ◽  
Odd Vinje ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Bone Mass ◽  
Bone Turnover ◽  
Controlled Study ◽  
Early Juvenile ◽  
Prospective Controlled Study

Effects of growth hormone (GH) replacement on bone metabolism and mineral density in adult onset of GH deficiency: results of a double-blind placebo-controlled study with open follow-up

1997 ◽  
Vol 136 (3) ◽  
pp. 282-289 ◽  
Author(s):  
Gerd Finkenstedt ◽  
Rudolf W Gasser ◽  
Günter Höfle ◽  
Christine Watfah ◽  
Leo Fridrich
Keyword(s):  
Lumbar Spine ◽  
Bone Mass ◽  
Bone Turnover ◽  
Gh Deficiency ◽  
Controlled Study ◽  
Type I ◽  
Adult Onset ◽  
Mineral Density ◽  
Markers Of Bone Turnover ◽  
Igf I

Abstract It is known that GH stimulates bone turnover and that GH-deficient adults have a lower bone mass than healthy controls. In order to evaluate the influences of GH replacement therapy on markers of bone turnover and on bone mineral density (BMD) in patients with adult onset GH deficiency, a doubleblind placebo-controlled study of treatment with recombinant human GH (rhGH; mean dose 2·4 IU daily) in 20 patients for 6 months and an extended open study of 6 to 12 months were conducted. Eighteen patients, fourteen men and four women, with a mean age of 44 years with adult onset GH deficiency were evaluated in the study. Compared with placebo, after 6 months serum calcium (2·39±0·02 vs 2·32±0·02 mmol/l, P=0·037) and phosphate (0·97±0·06 vs 0·75±0·05 mmol/l, P=0·011) increased and the index of phosphate excretion (0·03±0·03 vs 0·19±0·02, P<0·001) decreased significantly, and there was a significant increase in the markers of bone formation (osteocalcin, 64·8±11·8 vs 17·4±1·8 ng/ml, P<0·001; procollagen type I carboxyterminal propeptide (PICP), 195·3±26·4 vs 124·0±15·5 ng/ml, P=0·026) as well as those of bone resorption (type I collagen carboxyterminal telopeptide (ICTP), 8·9±1·2 vs 3·3±0·5 ng/ml, P<0·001; urinary hydroxyproline, 0·035±0·006 vs 0·018±0·002 mg/100 ml glomerular filtration rate, P=0·009). BMD did not change during this period of time. IGF-I was significantly higher in treated patients (306·5±45·3 vs 88·7±22·5 ng/ml, P<0·001). An analysis of the data compiled from 18 patients treated with rhGH for 12 months revealed similar significant increases in serum calcium and phosphate, and the markers of bone turnover (osteocalcin, PICP, ICTP, urinary hydroxyproline). Dual energy x-ray absorptiometry (DXA)-measured BMD in the lumbar spine (1·194±0·058 vs 1·133±0·046 g/cm2, P=0·015), femoral neck (1·009±0·051 vs 0·936±0·034 g/cm2, P=0·004), Ward's triangle (0·801±0·055 vs 0·816±0·04 g/cm2, P=0·019) and the trochanteric region (0·869±0·046 vs 0·801±0·033 g/cm2, P=0·005) increased significantly linearly (compared with the individual baseline values). At 12 months, BMD in patients with low bone mass (T-score < −1·0 s.d.) increased more than in those with normal bone mass (lumbar spine 11·5 vs 2·1%, P=0·030, and femoral neck 9·7 vs 4·2%, P=0·055). IGF-I increased significantly in all treated patients. In conclusion, treatment of GH-deficient adults with rhGH increases bone turnover for at least 12 months. BMD in the lumbar spine and the proximal femur increases continuously in this time (open study) and the benefit is greater in patients with low bone mass. Therefore, GH-deficient patients exhibiting osteopenia or osteoporosis should be considered candidates for GH supplementation. However, long-term studies are needed to establish that the positive effects on BMD are persistent and are associated with a reduction in fracture risk. European Journal of Endocrinology 136 282–289

The effects of transdermal estrogen therapy on bone mass and turnover in early postmenopausal smokers: A prospective, controlled study

2003 ◽  
Vol 189 (5) ◽  
pp. 1213-1220 ◽  
Author(s):  
Matti J Välimäki ◽  
Kalevi A Laitinen ◽  
Riitta K Tähtelä ◽  
Erkki J Hirvonen ◽  
Juha P Risteli
Keyword(s):  
Bone Mass ◽  
Estrogen Therapy ◽  
Controlled Study ◽  
Transdermal Estrogen ◽  
Prospective Controlled Study

Exercise-induced high bone mass is retained with long-term retirement from sports — A mean 39-year prospective controlled study in men

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S141 ◽  
Author(s):  
M. Tveit⁎ ◽  
B.E. Rosengren ◽  
J.-Å. Nilsson ◽  
H.G. Ahlborg ◽  
M.K. Karlsson
Keyword(s):  
Bone Mass ◽  
Controlled Study ◽  
High Bone Mass ◽  
High Bone ◽  
Exercise Induced ◽  
Prospective Controlled Study

scholarly journals Response to Letter: “Calcium and Bone Turnover Markers in Acromegaly: A Prospective, Controlled Study”

2017 ◽  
Vol 102 (9) ◽  
pp. 3561-3562
Author(s):  
Tina Constantin ◽  
Vin Tangpricha ◽  
Reshma Shah ◽  
Nelson M Oyesiku ◽  
Octavian Ioachimescu ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Controlled Study ◽  
Turnover Markers ◽  
Prospective Controlled Study

scholarly journals Does a childhood fracture predict low bone mass in young adulthood?-A 27-year prospective controlled study

2013 ◽  
Vol 28 (2) ◽  
pp. 351-359 ◽  
Author(s):  
Christian Buttazzoni ◽  
Bjorn E Rosengren ◽  
Magnus Tveit ◽  
Lennart Landin ◽  
Jan-Åke Nilsson ◽  
...  
Keyword(s):  
Bone Mass ◽  
Young Adulthood ◽  
Controlled Study ◽  
Low Bone Mass ◽  
Prospective Controlled Study

Bone mass following physical activity in young years: a mean 39-year prospective controlled study in men

2012 ◽  
Vol 24 (4) ◽  
pp. 1389-1397 ◽  
Author(s):  
M. Tveit ◽  
B. E. Rosengren ◽  
J-Å. Nilsson ◽  
H. G. Ahlborg ◽  
M. K. Karlsson
Keyword(s):  
Physical Activity ◽  
Bone Mass ◽  
Controlled Study ◽  
Prospective Controlled Study

scholarly journals Calcium and Bone Turnover Markers in Acromegaly: A Prospective, Controlled Study

2017 ◽  
Vol 102 (7) ◽  
pp. 2416-2424 ◽  
Author(s):  
Tina Constantin ◽  
Vin Tangpricha ◽  
Reshma Shah ◽  
Nelson M. Oyesiku ◽  
Octavian C. Ioachimescu ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Controlled Study ◽  
Turnover Markers ◽  
Prospective Controlled Study

scholarly journals Physical Activity at Growth Induce Bone Mass Benefits into Adulthood – A Fifteen‐Year Prospective Controlled Study

JBMR Plus ◽  
2021 ◽  
Author(s):  
Björn E. Rosengren ◽  
Jakob Rempe ◽  
Lars Jehpsson ◽  
Magnus Dencker ◽  
Magnus K. Karlsson
Keyword(s):  
Physical Activity ◽  
Bone Mass ◽  
Controlled Study ◽  
Prospective Controlled Study
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