scholarly journals The relationship between body composition and knee cartilage volume in healthy, middle-aged subjects

2005 ◽  
Vol 52 (2) ◽  
pp. 461-467 ◽  
Author(s):  
Flavia M. Cicuttini ◽  
Andrew J. Teichtahl ◽  
Anita E. Wluka ◽  
Susan Davis ◽  
Boyd J. G. Strauss ◽  
...  
Keyword(s):  
Body Composition ◽  
Cartilage Volume ◽  
Knee Cartilage ◽  
Middle Aged ◽  
Aged Subjects ◽  
The Relationship

Association of Baseline Knee Bone Size, Cartilage Volume, and Body Mass Index with Knee Cartilage Loss Over Time: A Longitudinal Study in Younger or Middle-aged Adults

2011 ◽  
Vol 38 (9) ◽  
pp. 1973-1980 ◽  
Author(s):  
BENNY ANTONY ◽  
CHANGHAI DING ◽  
OLIVER STANNUS ◽  
FLAVIA CICUTTINI ◽  
GRAEME JONES
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cartilage Volume ◽  
Bone Size ◽  
Cartilage Loss ◽  
Annual Change ◽  
Knee Cartilage ◽  
Middle Aged ◽  
Negatively Associated ◽  
Middle Aged Adults

Objective.To determine the association of knee bone size, cartilage volume, and body mass index (BMI) at baseline with knee cartilage loss over 2 years in younger or middle-aged adults.Methods.A total of 324 subjects (mean age 45 yrs, range 26–61) were measured at baseline and about 2 years later. Knee cartilage volume and bone size were determined using T1-weighted fat-saturated magnetic resonance imaging.Results.In multivariable analysis, baseline knee bone size was negatively associated with annual change in knee cartilage volume at medial and lateral tibial sites (ß = −0.62% to −0.47%/cm2, all p < 0.001). The associations disappeared at medial tibial site after adjustment for baseline cartilage volume and became of borderline statistical significance at lateral tibial site after adjustment for both baseline cartilage volume and osteophytes (ß = −0.29, p = 0.059). Baseline knee cartilage volume was consistently and negatively associated with annual change in knee cartilage volume at all 3 medial tibial, lateral tibial, and patellar sites (ß = −4.41% to −1.37%/ml, all p < 0.001). Baseline BMI was negatively associated with an annual change in knee cartilage volume, but only in subjects within the upper tertile of baseline cartilage volume, even after adjusting for cartilage defects (ß = −0.16% to −0.34%/kg/m2, all p < 0.05).Conclusion.Our study suggests that both higher baseline tibial bone area and knee cartilage volume (most likely due to cartilage swelling) are associated with greater knee cartilage loss over 2 years. A higher BMI was associated with greater knee cartilage loss only in subjects with higher baseline cartilage volume.

scholarly journals Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study

2007 ◽  
Vol 9 (4) ◽  
pp. R66 ◽  
Author(s):  
Yuanyuan Wang ◽  
Allison M Hodge ◽  
Anita E Wluka ◽  
Dallas R English ◽  
Graham G Giles ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Knee Cartilage ◽  
Middle Aged ◽  
Cross Sectional ◽  
Aged Subjects
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