scholarly journals Association between stromal cell-derived factor 1 chemokine gene variant and radiographic progression of rheumatoid arthritis

2005 ◽  
Vol 52 (1) ◽  
pp. 354-356 ◽  
Author(s):  
Beatriz Joven ◽  
Nuria González ◽  
Francisco Aguilar ◽  
Begoña Santiago ◽  
María Galindo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Stromal Cell ◽  
Radiographic Progression ◽  
Gene Variant ◽  
Chemokine Gene ◽  
Stromal Cell Derived Factor

scholarly journals The role of a stromal cell-derived factor-1 chemokine gene variant in the clinical course of HIV-1 infection

AIDS ◽  
1998 ◽  
Vol 12 (9) ◽  
pp. F85-F90 ◽  
Author(s):  
Ronald P. van Rij ◽  
Silvia Broersen ◽  
Jaap Goudsmit ◽  
Roel A. Coutinho ◽  
Hanneke Schuitemaker
Keyword(s):  
Stromal Cell ◽  
Clinical Course ◽  
Gene Variant ◽  
Chemokine Gene ◽  
Stromal Cell Derived Factor ◽  
Hiv 1

Stromal-cell derived factor-1 chemokine gene variant is associated with type 1 diabetes age at onset in Japanese population

2003 ◽  
Vol 64 (10) ◽  
pp. 973-978 ◽  
Author(s):  
Akane Ide ◽  
Eiji Kawasaki ◽  
Norio Abiru ◽  
Fuyan Sun ◽  
Tetsuya Fukushima ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Japanese Population ◽  
Stromal Cell ◽  
Age At Onset ◽  
Gene Variant ◽  
Chemokine Gene ◽  
Stromal Cell Derived Factor

scholarly journals A Common Stromal Cell-Derived Factor-1 Chemokine Gene Variant is Associated With the Early Onset of Type 1 Diabetes

Diabetes ◽  
2001 ◽  
Vol 50 (5) ◽  
pp. 1211-1213 ◽  
Author(s):  
D. Dubois-Laforgue ◽  
H. Hendel ◽  
S. Caillat-Zucman ◽  
J.-F. Zagury ◽  
C. Winkler ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Early Onset ◽  
Stromal Cell ◽  
Gene Variant ◽  
Chemokine Gene ◽  
Stromal Cell Derived Factor

scholarly journals Stromal cell-derived factor-1 chemokine gene variant in blood donors and chronic myelogenous leukemia patients

2007 ◽  
Vol 21 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Carlos Eduardo Coral de Oliveira ◽  
Gabriela Gonçalves de Oliveira Cavassin ◽  
Aparecida de Lourdes Perim ◽  
Thiago Franco Nasser ◽  
Karen Brajão de Oliveira ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
Stromal Cell ◽  
Blood Donors ◽  
Myelogenous Leukemia ◽  
Gene Variant ◽  
Chemokine Gene ◽  
Stromal Cell Derived Factor

Stromal Cell Derived Factor-1 (CXCL12) Chemokine Gene Variant in Myeloid Leukemias

2014 ◽  
Vol 60 (05/2014) ◽  
Author(s):  
Hoda El-Ghany ◽  
Zainab El-Saadany ◽  
Nevien Bahaa ◽  
Noha Ibrahim ◽  
Salwa Hussien
Keyword(s):  
Stromal Cell ◽  
Gene Variant ◽  
Chemokine Gene ◽  
Myeloid Leukemias ◽  
Stromal Cell Derived Factor

Stromal Cell-Derived Factor-1 Chemokine Gene Polymorphism Is Not Associated with Onset Age of Japanese Type 1 Diabetes

2003 ◽  
Vol 1005 (1) ◽  
pp. 328-331 ◽  
Author(s):  
TOSHIKATSU SHIGIHARA ◽  
AKIRA SHIMADA ◽  
SATORU YAMADA ◽  
TARO MARUYAMA ◽  
HIROSHI HIROSE ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gene Polymorphism ◽  
Stromal Cell ◽  
Onset Age ◽  
Chemokine Gene ◽  
Stromal Cell Derived Factor

scholarly journals Addition of Fibroblast-Stromal Cell Markers to Immune Synovium Pathotypes Better Predicts Radiographic Progression at 1 Year in Active Rheumatoid Arthritis

2021 ◽  
Vol 12 ◽  
Author(s):  
Xue-Pei Zhang ◽  
Jian-Da Ma ◽  
Ying-Qian Mo ◽  
Jun Jing ◽  
Dong-Hui Zheng ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Stromal Cell ◽  
Active Rheumatoid Arthritis ◽  
Radiographic Progression ◽  
Positive Staining ◽  
Cell Markers ◽  
Treatment Naïve ◽  
Modified Total Sharp Score

ObjectivesThis study aims to investigate if addition of fibroblast-stromal cell markers to a classification of synovial pathotypes improves their predictive value on clinical outcomes in rheumatoid arthritis (RA).MethodsActive RA patients with a knee needle synovial biopsy at baseline and finished 1-year follow-up were recruited from a real-world prospective cohort. Positive staining for CD20, CD38, CD3, CD68, CD31, and CD90 were scored semiquantitatively (0-4). The primary outcome was radiographic progression defined as a minimum increase of 0.5 units of the modified total Sharp score from baseline to 1 year.ResultsAmong 150 recruited RA patients, 123 (82%) had qualified synovial tissue. Higher scores of CD20+ B cells, sublining CD68+ macrophages, CD31+ endothelial cells, and CD90+ fibroblasts were associated with less decrease in disease activity and greater increase in radiographic progression. A new fibroblast-based classification of synovial pathotypes giving more priority to myeloid and stromal cells classified samples as myeloid-stromal (57.7%, 71/123), lymphoid (31.7%, 39/123), and paucicellular pathotypes (10.6%, 13/123). RA patients with myeloid-stromal pathotype showed the highest rate of radiographic progression (43.7% vs. 23.1% vs. 7.7%, p = 0.011), together with the lowest rate of Boolean remission at 3, 6, and 12 months. Baseline synovial myeloid-stromal pathotype independently predicted radiographic progression at 1 year (adjusted OR: 3.199, 95% confidence interval (95% CI): 1.278, 8.010). Similar results were obtained in a subgroup analysis of treatment-naive RA.ConclusionsThis novel fibroblast-based myeloid-stromal pathotype could predict radiographic progression at 1 year in active RA patients which may contribute to the shift of therapeutic decision in RA.

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