scholarly journals Comprehensive assessment of clinical outcome and quality of life after total shoulder arthroplasty: Usefulness and validity of subjective outcome measures

2004 ◽  
Vol 51 (5) ◽  
pp. 819-828 ◽  
Author(s):  
Felix Angst ◽  
G�za Pap ◽  
Anne F. Mannion ◽  
Daniel B. Herren ◽  
Andr� Aeschlimann ◽  
...  
2017 ◽  
Vol 99 (12) ◽  
pp. 1030-1035 ◽  
Author(s):  
Chul-Hyun Cho ◽  
Kwang-Soon Song ◽  
Ilseon Hwang ◽  
Margaret S. Coats-Thomas ◽  
Jon J.P. Warner

Neurology ◽  
2019 ◽  
Vol 93 (21) ◽  
pp. e1932-e1943 ◽  
Author(s):  
Minal S. Jain ◽  
Katherine Meilleur ◽  
Eunhee Kim ◽  
Gina Norato ◽  
Melissa Waite ◽  
...  

ObjectiveTo identify the rate of change of clinical outcome measures in children with 2 types of congenital muscular dystrophy (CMD), COL6-related dystrophies (COL6-RDs) and LAMA2-related dystrophies (LAMA2-RDs).MethodsOver the course of 4 years, 47 individuals (23 with COL6-RD and 24 with LAMA2-RD) 4 to 22 years of age were evaluated. Assessments included the Motor Function Measure 32 (MFM32), myometry (knee flexors and extensors, elbow flexors and extensors), goniometry (knee and elbow extension), pulmonary function tests, and quality-of-life measures. Separate linear mixed-effects models were fitted for each outcome measurement, with subject-specific random intercepts.ResultsTotal MFM32 scores for COL6-RDs and LAMA2-RDs decreased at a rate of 4.01 and 2.60 points, respectively, each year (p < 0.01). All muscle groups except elbow flexors for individuals with COL6-RDs decreased in strength between 1.70% (p < 0.05) and 2.55% (p < 0.01). Range-of-motion measurements decreased by 3.21° (p < 0.05) at the left elbow each year in individuals with LAMA2-RDs and 2.35° (p < 0.01) in right knee extension each year in individuals with COL6-RDs. Pulmonary function demonstrated a yearly decline in sitting forced vital capacity percent predicted of 3.03% (p < 0.01) in individuals with COL6-RDs. There was no significant change in quality-of-life measures analyzed.ConclusionResults of this study describe the rate of change of motor function as measured by the MFM32, muscle strength, range of motion, and pulmonary function in individuals with COL6-RDs and LAMA2-RDs.


2005 ◽  
Vol 87 (10) ◽  
pp. 2178-2185 ◽  
Author(s):  
IAN K.Y. LO ◽  
ROBERT B. LITCHFIELD ◽  
SHARON GRIFFIN ◽  
KEN FABER ◽  
STUART D. PATTERSON ◽  
...  

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012640
Author(s):  
Rosemarie H.M.J.M. Kroon ◽  
Johanna G. Kalf ◽  
Bert J.M. de Swart ◽  
Barbara M. van der Sluijs ◽  
Jeffrey C. Glennon ◽  
...  

ObjectiveOculopharyngeal muscular dystrophy (OPMD) is a late-onset, progressive muscle disease. Disease progression is known to be slow, but details on the natural history remain unknown. We aimed to examine the natural history of OPMD in a large nationwide cohort to determine clinical outcome measures that capture disease progression and can be used in future clinical trials.MethodsPatients, invited by their treating physicians or from the national neuromuscular database, and invited family members, were examined twice, 20 months apart, using fixed dynamometry, MRC grading, maximum bite force and isometric tongue strength, Motor Function Measure (MFM), 10-step stair test, maximum swallowing-, chewing-, and speech-tasks and quality of life assessments.ResultsDisease progression was captured by 8 out of 18 measures over 20 months in forty-three genetically confirmed OPMD patients. The largest deterioration was seen in deltoid muscle strength (-27% (range -17 – -37%)), followed by the quadriceps (-14% (range -6 – -23%)), iliopsoas (-12.2%), tongue (-9.9%) and MRC sum-score (-2.5%). The 10-step stair test (-12.5%), MFM part D1 (-7.1%), and maximum repetition rate of /pa/ (-5.3%) showed a significant decrease as well (all p<0.05). Domain ‘Physical functioning’ of the SF-36 Health Survey significantly deteriorated (p=0.044). No relationship was found between disease progression and genotype or disease duration (p>0.05).ConclusionsDespite the slow disease progression of OPMD, this study showed that several outcome measures detected progression within 20 months. The deltoid muscle strength, measured by fixed dynamometry, showed the greatest decline. This longitudinal data provides clinical outcome measures that can be used as biomarkers in future clinical trials.


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