Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice

2004 ◽  
Vol 50 (9) ◽  
pp. 3023-3034 ◽  
Author(s):  
Julia L. Gregory ◽  
Michelle T. Leech ◽  
John R. David ◽  
Yuan H. Yang ◽  
April Dacumos ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Cell Interactions ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Deficient Mice

Impaired fracture healing in macrophage migration inhibitory factor-deficient mice

2010 ◽  
Vol 22 (6) ◽  
pp. 1955-1965 ◽  
Author(s):  
T. Kobayashi ◽  
S. Onodera ◽  
E. Kondo ◽  
H. Tohyama ◽  
H. Fujiki ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Deficient Mice

scholarly journals The role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in mice

2013 ◽  
Vol 65 (2) ◽  
pp. 499-505 ◽  
Author(s):  
Tamara Saksida ◽  
Stanislava Stosic-Grujicic ◽  
Ivana Stojanovic
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Intolerance ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Clinical Signs ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Deficient Mice

Macrophage migration inhibitory factor (MIF) is implicated in the pathogenesis of several inflammationrelated diseases, including obesity and type 2 diabetes (T2D). However, MIF deficiency itself promotes obesity and glucose intolerance in mice. Here we show that the introduction of a high-fat diet (HFD) further aggravates the parameters of obesity-associated T2D: weight gain and glucose intolerance. Furthermore, in contrast to MIF-KO mice on standard chow, HFD-fed MIF-KO mice develop insulin resistance. Although the clinical signs of obesity-associated T2D are upgraded, inflammation in MIF-deficient mice on HFD is significantly lower. These results imply that MIF possesses a complex role in glucose metabolism and the development of obesity-related T2D. However, the downregulation of inflammation upon MIF inhibition could be a useful tool in short-term T2D therapy for preventing pancreatic islet deterioration.

scholarly journals Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss

FEBS Letters ◽  
2006 ◽  
Vol 580 (5) ◽  
pp. 1251-1256 ◽  
Author(s):  
Shigeki Oshima ◽  
Shin Onodera ◽  
Norio Amizuka ◽  
Minqi Li ◽  
Kazuharu Irie ◽  
...  
Keyword(s):  
Bone Loss ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Deficient Mice
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