scholarly journals Assessment of atherosclerotic risk factors and endothelial function in children and young adults with pediatric-onset systemic lupus erythematosus

2004 ◽  
Vol 51 (3) ◽  
pp. 451-457 ◽  
Author(s):  
Jennifer B. Soep ◽  
Michele Mietus-Snyder ◽  
Mary J. Malloy ◽  
Joseph L. Witztum ◽  
Emily Von Scheven
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Young Adults ◽  
Endothelial Function ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Children And Young Adults ◽  
Atherosclerotic Risk Factors ◽  
Pediatric Onset ◽  
Onset Systemic Lupus Erythematosus

Endothelial function analysis and atherosclerotic risk factors in adolescents with systemic lupus erythematosus

2007 ◽  
Vol 19 (4) ◽  
Author(s):  
Ana Karina Soares Nascif ◽  
Maria Odete Esteves Hilärio ◽  
Maria Teresa Ramos Ascensäo Terrer ◽  
Sergio Aron Ajzen ◽  
Vänia D'Almeida ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Endothelial Function ◽  
Lupus Erythematosus ◽  
Function Analysis ◽  
Systemic Lupus ◽  
Atherosclerotic Risk Factors

Frequency of osteopenia in children and young adults with childhood-onset systemic lupus erythematosus

2005 ◽  
Vol 52 (7) ◽  
pp. 2051-2059 ◽  
Author(s):  
Vibke Lilleby ◽  
Gunhild Lien ◽  
Kathrine Frey Frøslie ◽  
Margaretha Haugen ◽  
Berit Flatø ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Young Adults ◽  
Lupus Erythematosus ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Children And Young Adults ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Complement deficiency in pediatric-onset systemic lupus erythematosus

2018 ◽  
Vol 10 (02) ◽  
pp. 232-236 ◽  
Author(s):  
Parisa Afzali ◽  
Anna Isaeian ◽  
Peyman Sadeghi ◽  
Bobak Moazzami ◽  
Nima Parvaneh ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Musculoskeletal Symptoms ◽  
Complement C3 ◽  
Complement Deficiency ◽  
Control Group ◽  
Systemic Lupus ◽  
Cutaneous Manifestations ◽  
Pediatric Onset ◽  
Onset Systemic Lupus Erythematosus

Abstract BACKGROUND: Pediatric-onset systemic lupus erythematosus (pSLE) accounts for about 10%-20% of all patients with SLE. Deficiencies in early complement components of the classical pathway are the strong genetic risk factor for the development of SLE. In this study, clinical and laboratory manifestations of both complement-deficient and normal complement pSLE patients were compared. MATERIALS AND METHODS: To investigate clinical and immunological manifestations of pSLE in Iran, 36 consecutive pSLE patients (onset before 18 years) who were followed up over a period of 2 years, were studied. Complement C1q and C2 levels were measured using radial immunodifusion assay and complement C3 and C4 levels were measured using nephelometry. Medical records were retrospectively evaluated from patient database of Children Medical Center Hospital. Data were assessed through descriptive analysis (confidence interval = 95%), paired t-test, and Pearson correlation test. RESULTS: Twenty-one patients (58%) had at least one component of complement deficiency. Ten patients (27%) had low C1q level, 11 patients (30.5%) had low C2, nine patients (25%) had low C3, and four patients (11%) had low C4 level. Serum level of complement in pSLE was significantly lower than the control group, except C4 (P = 0.005). The low C1q patients had an earlier age of onset of disease (P < 0.0001). The cutaneous manifestations were more frequent and much more severe in pSLE with low complement (100% vs. 73%). The frequency of renal and musculoskeletal symptoms was equal, but renal morbidity was more common in pSLE with low complement. Positivity for anti-ds-DNA was less common in pSLE with low complement (71% vs. 86%). CONCLUSION: In pSLE patients with early disease onset and more aggressive SLE manifestations and negative anti-ds-DNA test, complement deficiency should be considered.

scholarly journals The Impact of Serum Anti-neutrophil Cytoplasmic Antibody on Clinical Characteristics and Outcomes in Pediatric-Onset Systemic Lupus Erythematosus Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Chun-Chun Gau ◽  
Min-Hua Tseng ◽  
Chao-Yi Wu ◽  
Huang-Yu Yang ◽  
Jing-Long Huang
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Characteristics ◽  
Laboratory Data ◽  
Systemic Lupus ◽  
Retrospective Case ◽  
Clinical Presentations ◽  
The Impact ◽  
Pediatric Onset ◽  
Onset Systemic Lupus Erythematosus

Background: Systemic lupus erythematosus (SLE), an autoimmune disease, is characterized by the overproduction of autoantibodies. Anti-neutrophil cytoplasmic antibodies (ANCAs) have been recognized in SLE for decades. To date, their association with SLE disease activity, especially in pediatric-onset SLE (pSLE) patients, is limited.Methods: We conducted a retrospective case-control study of pSLE patients with ANCAs from 2010 to 2020. Clinical characteristics, laboratory data, renal histological features, treatment and outcomes were analyzed.Results: A total of 70 pediatric-onset SLE patients (9 ANCA-positive vs. 61 ANCA-negative) with a median age of 12.23 years (age ranging from 4 years to 18 years) at diagnosis were enrolled. Among patients with ANCAs, MPO-ANCA was found in seven and PR3-ANCA in two of those cases. Patients with ANCAs had a tendency to have hematuria compared with those without ANCAs (66 vs. 24.6%, respectively; p = 0.026). Of the 70 SLE patients, 8 with ANCAs and 44 without ANCAs underwent renal biopsies. Patients with ANCAs (25%, 2/8) were more likely to lack the typical full-house pattern in their renal immunofluorescence (IF) staining.Conclusion: pSLE patients with ANCAs tend to have hematuria and an absence of typical IF histology. However, patients with and without ANCAs showed no difference in their clinical presentations and treatment outcomes.

scholarly journals Nocturnal Blood Pressure Dipping As a Marker of Endothelial Function and Subclinical Atherosclerosis in Pediatric-onset Systemic Lupus Erythematosus

2020 ◽  
Author(s):  
Joyce C Chang ◽  
Rui Xiao ◽  
Kevin E Meyers ◽  
Laura Mercer-Rosa ◽  
Shobha S Natarajan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelial Function ◽  
Lupus Erythematosus ◽  
Aortic Stiffness ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Systemic Lupus ◽  
Media Thickness ◽  
Pediatric Onset ◽  
Onset Systemic Lupus Erythematosus

Abstract Background: Loss of the normal nocturnal decline in blood pressure (BP), known as non-dipping, is a potential measure of cardiovascular risk identified by ambulatory blood pressure monitoring (ABPM). We sought to determine whether non-dipping is a useful marker of abnormal vascular function and subclinical atherosclerosis in pediatric-onset systemic lupus erythematosus (pSLE). Methods: Twenty subjects 9-19 years of age with pSLE underwent ABPM, peripheral endothelial function testing, carotid-femoral pulse wave velocity/analysis for aortic stiffness, and carotid intima-media thickness. We assessed the prevalence of non-dipping and other ABPM abnormalities. Pearson or Spearman rank correlation tests were used to evaluate relationships between nocturnal BP dipping, BP load (% of abnormally elevated BPs over 24-hours) and vascular outcome measures. Results: The majority (75%) of subjects had inactive disease, with mean disease duration of 3.2 years (±2.1). The prevalence of non-dipping was 50%, which occurred even in the absence of nocturnal or daytime hypertension. Reduced diastolic BP dipping was associated with poorer endothelial function (𝒓 0.5, p=0.04). Intima-media thickness was significantly greater in subjects with non-dipping (mean standard deviation score of 3.0 vs 1.6, p=0.02). In contrast, higher systolic and diastolic BP load were associated with increased aortic stiffness (𝜌 0.6, p=0.01 and 𝜌 0.7, p<0.01, respectively), but not with endothelial function or intima-media thickness. Conclusion: In a pSLE cohort with low disease activity, isolated nocturnal BP non-dipping is prevalent and associated with endothelial dysfunction and atherosclerotic changes. In addition to hypertension assessment, ABPM has a promising role in risk stratification and understanding heterogeneous mechanisms of cardiovascular disease in pSLE.

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