scholarly journals Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblasts

2004 ◽  
Vol 50 (5) ◽  
pp. 1448-1456 ◽  
Author(s):  
Edita Rutkauskaite ◽  
Wolfgang Zacharias ◽  
Jörg Schedel ◽  
Ulf Müller-Ladner ◽  
Christian Mawrin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Synovial Fibroblasts ◽  
Matrix Metalloproteinase 1

scholarly journals Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1)

1998 ◽  
Vol 331 (1) ◽  
pp. 341-346 ◽  
Author(s):  
Matthew P. VINCENTI ◽  
Charles I. COON ◽  
J. Andrew MENGSHOL ◽  
Sue YOCUM ◽  
Peter MITCHELL ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Time Course ◽  
Interleukin 1 ◽  
Connective Tissue Diseases ◽  
Synovial Fibroblasts ◽  
Matrix Metalloproteinase 1 ◽  
Rabbit Gene ◽  
Factor Α ◽  
Interstitial Collagenase

Cartilage, bone and the interstitial stroma, composed largely of the interstitial collagens, types I, II and III, are remodelled by three members of the metalloproteinase (MMP) family, collagenase-1 (MMP-1), collagenase-2 (MMP-8) and collagenase-3 (MMP-13). MMP-1 and MMP-13 may contribute directly to disease progression, since they are induced in patients with rheumatoid arthritis and osteoarthritis. The study of MMP-1 and MMP-13 gene regulation in models of arthritic disease has been problematic because mice and rats, which are typically used, only possess a homologue of MMP-13. Here we show that in contrast with mice and rats, rabbits possess distinct genes homologous to human MMP-1 and MMP-13. Furthermore, rabbit MMP-13 is expressed simultaneously with MMP-1 in chondrocytes and synovial fibroblasts in response to the cytokines interleukin-1 and tumour necrosis factor-α, or the phorbol ester PMA. The time course of MMP-13 induction is more rapid and transient than that of MMP-1, suggesting that distinct mechanisms regulate the expression of these two collagenases. We have cloned the rabbit MMP-13 gene from synovial fibroblasts and demonstrated that the rabbit gene shares greater homology with human MMP-13 than does the mouse interstitial collagenase. Together with the fact that mice and rats do not possess a homologue to human MMP-1, our data suggest that the rabbit provides an appropriate model for studying the roles of interstitial collagenases in connective-tissue diseases, such as rheumatoid arthritis and osteoarthritis.

Inhibitory effect of mizoribine on matrix metalloproteinase-1 production in synovial fibroblasts and THP-1 macrophages

2005 ◽  
Vol 15 (4) ◽  
pp. 264-268 ◽  
Author(s):  
Binbin Zhong ◽  
Michiko Tajima ◽  
Hidenari Takahara ◽  
Hiromi Nochi ◽  
Koichi Tamoto ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Synovial Fibroblasts ◽  
Inhibitory Effect ◽  
Matrix Metalloproteinase 1

scholarly journals Interleukin-4 stimulates rheumatoid synovial fibroblasts to express matrix metalloproteinase-1 (tissue collagenase) and histamine H1 receptor mRNA

IUBMB Life ◽  
1996 ◽  
Vol 40 (6) ◽  
pp. 1253-1260 ◽  
Author(s):  
Michihisa Zenmyo ◽  
Koji Hiraoka ◽  
Takakazu Sasaguri ◽  
Setsuro Komiya ◽  
Akio Inoue ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Synovial Fibroblasts ◽  
Interleukin 4 ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Receptor Mrna ◽  
Matrix Metalloproteinase 1
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