scholarly journals “Homozygosity” for the HLA–DR shared epitope contributes the highest risk for rheumatoid arthritis concordance in identical twins

1994 ◽  
Vol 37 (5) ◽  
pp. 681-686 ◽  
Author(s):  
D. Jawaheer ◽  
W. Thomson ◽  
A. J. Macgregor ◽  
D. Carthy ◽  
J. Davidson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Shared Epitope ◽  
Identical Twins ◽  
Hla Dr

scholarly journals The shared epitope revisited: shared epitope negative HLA-DR alleles influence susceptibility to rheumatoid arthritis

10.1186/ar272 ◽  
2001 ◽  
Vol 3 (S2) ◽  
Author(s):  
D Reviron ◽  
A Perdriger ◽  
E Toussirot ◽  
D Wendling ◽  
N Balandraud ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Shared Epitope ◽  
Hla Dr

Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles

2008 ◽  
Vol 68 (5) ◽  
pp. 736-743 ◽  
Author(s):  
O Snir ◽  
M Widhe ◽  
C von Spee ◽  
J Lindberg ◽  
L Padyukov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Shared Epitope ◽  
Type Ii Collagen ◽  
Cross Reactivity ◽  
Igg Antibodies ◽  
Serum Samples ◽  
Hla Dr ◽  
Citrullinated Proteins ◽  
The Relationship ◽  
Citrullinated Protein

Background:Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis (RA), and associate with HLA-DRB1 shared epitope (SE) alleles.Objective:To investigate reactivities of anti-CCP to various citrullinated proteins/peptides, which represent potential autoantigens in RA, and to examine the relationship between such antibodies, and their association with genetic variants within HLA-DRB1 SE alleles.Methods:Serum samples from 291 patients with established RA and 100 sex- and age-matched healthy subjects were included in this study. Sera were first analysed for presence of anti-CCP antibodies and further for IgG and IgA antibodies towards candidate autoantigens in both their native and citrullinated form including: fibrinogen, α-enolase peptide-1 and the C1-epitope of type II collagen (C1III). Antibody specificity was confirmed by cross-reactivity tests. HLA-DR genotyping was performed.Results:72% of patients with RA were anti-CCP positive. Among the candidate autoantigens examined, IgG antibodies to citrullinated fibrinogen were found in 66% of patients’ sera and in 41% for both citrullinated α-enolase peptide-1 and citrullinated C1III. These antibodies were mainly seen in the anti-CCP-positive patient group; they were specific for their respective antigen and displayed limited cross reactivity. IgA responses were also detected, but less frequently than IgG. Anti-CCP and anti-citrullinated protein antibodies were associated with HLA-DRB1*04 rather than with HLA-DRB1*01 alleles.Conclusions:Antibodies directed against several citrullinated antigens are present in CCP-positive RA, with many patients displaying multireactivity. All specific reactivities were primarily associated with the HLA-DRB1*04 alleles, suggesting common pathways of anti-citrulline immunity.

scholarly journals A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

2005 ◽  
Vol 54 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Lars Klareskog ◽  
Patrik Stolt ◽  
Karin Lundberg ◽  
Henrik Källberg ◽  
Camilla Bengtsson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Shared Epitope ◽  
Immune Reactions ◽  
New Model ◽  
Hla Dr

A rapid semi automated method for DNA extraction from dried-blood spots: Application to the HLA-DR shared epitope analysis in rheumatoid arthritis

2007 ◽  
Vol 328 (1-2) ◽  
pp. 220-225 ◽  
Author(s):  
Alexandre Pachot ◽  
Véronique Barbalat ◽  
Hubert Marotte ◽  
Jennifer Diasparra ◽  
Aurore Gouraud ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dna Extraction ◽  
Shared Epitope ◽  
Dried Blood Spots ◽  
Blood Spots ◽  
Epitope Analysis ◽  
Automated Method ◽  
Hla Dr

scholarly journals THU0006 Dqb1 polymorphism in rheumatoid arthritis patients with shared epitope-negative drb1 alleles

2001 ◽  
Author(s):  
R Zunec ◽  
Z Grubic ◽  
D Babic-Naglic ◽  
N Laktasic-Zerjavic ◽  
K Potocki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Shared Epitope
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