scholarly journals Human synovial fibroblast plasminogen activator. modulation of enzyme activity by antiinflammatory steroids

1981 ◽  
Vol 24 (10) ◽  
pp. 1296-1303 ◽  
Author(s):  
John A. Hamilton ◽  
Alison Bootes ◽  
Paul E. Phillips ◽  
J. Slywka
Keyword(s):  
Enzyme Activity ◽  
Plasminogen Activator ◽  
Synovial Fibroblast ◽  
Human Synovial Fibroblast ◽  
Antiinflammatory Steroids

scholarly journals Streptococcal cell walls and synovial cell activation. Stimulation of synovial fibroblast plasminogen activator activity by monocytes treated with group A streptococcal cell wall sonicates and muramyl dipeptide.

1982 ◽  
Vol 155 (6) ◽  
pp. 1702-1718 ◽  
Author(s):  
J A Hamilton ◽  
J B Zabriskie ◽  
L B Lachman ◽  
Y S Chen
Keyword(s):  
Cell Wall ◽  
Plasminogen Activator ◽  
Synovial Fibroblast ◽  
Cell Activation ◽  
Interleukin 2 ◽  
Muramyl Dipeptide ◽  
Cellular Interactions ◽  
Human Monocytes ◽  
Streptococcal Cell Wall ◽  
Group A

Group A streptococcal peptidoglycan has previously been shown to be arthritogenic in rats and has been implicated as a structure present in a class of possible etiologic agents for rheumatoid arthritis. The present study reports that conditioned medium from human monocytes, after interaction with cell wall sonicates of four group A streptococcal strains, stimulates the plasminogen activator (PA) activity of nonrheumatoid synovial fibroblasts. Low concentrations of N-acetylmuramyl-L-alanyl-D isoglutamine (muramyl dipeptide) can also generate this synovial activator (SA) activity from human monocytes. Preliminary biochemical data suggest that the SA activity is distinct from interferon-gamma, interleukin 1, and interleukin 2. These results indicate that agents that are arthritogenic in rats can modulate human synovial fibroblast functions via monocytes. The findings are proposed to have possible significance for an understanding of the cellular interactions involved in the formation and function of the rheumatoid pannus, because PA has been invoked as possibly being generally important for the processes of cell migration, tissue remodeling, and inflammation.

scholarly journals Regulation of human synovial fibroblast collagenase messenger RNA by interleukin-1

1989 ◽  
Vol 32 (12) ◽  
pp. 1539-1545 ◽  
Author(s):  
S. Spence McCachren ◽  
Paula K. Greer ◽  
James E. Niedel
Keyword(s):  
Synovial Fibroblast ◽  
Messenger Rna ◽  
Interleukin 1 ◽  
Human Synovial Fibroblast ◽  
Fibroblast Collagenase

The Role of Protein Kinase in Human Synovial Fibroblast Growth

1995 ◽  
Vol 210 (3) ◽  
pp. 1066-1075 ◽  
Author(s):  
K. Migita ◽  
K. Eguchi ◽  
T. Tsukada ◽  
Y. Kawabe ◽  
T. Aoyagi ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Synovial Fibroblast ◽  
Fibroblast Growth ◽  
Human Synovial Fibroblast

scholarly journals BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death

Oncotarget ◽  
2016 ◽  
Vol 7 (17) ◽  
pp. 23370-23382 ◽  
Author(s):  
Biserka Relic ◽  
Edith Charlier ◽  
Celine Deroyer ◽  
Olivier Malaise ◽  
Sophie Neuville ◽  
...  
Keyword(s):  
Cell Death ◽  
Glucocorticoid Receptor ◽  
Synovial Fibroblast ◽  
Fibroblast Cell ◽  
Receptor Activation ◽  
Human Synovial Fibroblast
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