scholarly journals Functional renal involvement in normotensive patients with progressive systemic sclerosis. impaired sodium excretion during isotonic saline infusion

1981 ◽  
Vol 24 (1) ◽  
pp. 8-11 ◽  
Author(s):  
A D'Angelo ◽  
P Messa ◽  
U Fiocco ◽  
A Fabris ◽  
P Morachiello ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Sodium Excretion ◽  
Renal Involvement ◽  
Isotonic Saline ◽  
Progressive Systemic Sclerosis ◽  
Saline Infusion

Marked Improvement of Skin Involvement in Severe Progressive Systemic Sclerosis after Transplantation of Mesenchymal Stem Cells from an Allogeneic Haploidentical Related Donor.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4865-4865
Author(s):  
Maximilian Christopeit ◽  
Marit Schendel ◽  
Lutz Peter Mueller ◽  
Gernot Keyszer ◽  
Gerhard Behre
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Systemic Sclerosis ◽  
Renal Involvement ◽  
Progressive Systemic Sclerosis ◽  
In Vitro Expansion ◽  
Modified Rodnan Skin Score ◽  
Diffuse Cutaneous Systemic Sclerosis ◽  
Related Donor

Abstract Introduction. Mesenchymal stem cells (MSC) show immunosuppressive capacity in an allogeneic host. Severe progressive systemic sclerosis (SSc) is an autoimmune disease in which prognosis is worsened in individuals presenting with diffuse cutaneous, lung and renal involvement. Immunosuppression can improve the course of the disease. Methods. We transplanted a 41 year old female patient suffering from diffuse cutaneous systemic sclerosis with MSC from her father after in vitro expansion of the MSC. Results. The patient presented with a remarkable clinical response. Her ulcer surface decreased, the 17 Site Modified Rodnan Skin Score, vascular ultrasound, mouth aperture, the Visual Analogue Scale for pain (VAS), the Valentini Activity Score and the Hannover Functional Questionnaire showed encouraging improvements. The patient did not experience any adverse events during the first 300 days after transplantation. Conclusions. The transplantation of MSC from a haploidentical donor into a patient with systemic sclerosis is feasible, safe and effective. Furthermore is the transplantation of MSC from a haploidentical donor into an adult without severe pharmacological immunosuppression at the time of transplantation feasible and safe.

Renal involvement in progressive systemic sclerosis (generalized scleroderma)

1957 ◽  
Vol 23 (3) ◽  
pp. 445-462 ◽  
Author(s):  
Gerald P. Rodnan ◽  
George E. Schreiner ◽  
Roger L. Black
Keyword(s):  
Systemic Sclerosis ◽  
Renal Involvement ◽  
Progressive Systemic Sclerosis

Factors Predicting Development of Renal Involvement in Progressive Systemic Sclerosis

1984 ◽  
Vol 132 (5) ◽  
pp. 1068-1068
Author(s):  
V.D. Steen ◽  
T.A. Medsger ◽  
T.A. Osial ◽  
G.L. Ziegler ◽  
A.P. Shapiro ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Renal Involvement ◽  
Progressive Systemic Sclerosis

Factors predicting development of renal involvement in progressive systemic sclerosis

1984 ◽  
Vol 76 (5) ◽  
pp. 779-786 ◽  
Author(s):  
Virginia D. Steen ◽  
Thomas A. Medsger ◽  
Thaddeus A. Osial ◽  
Gayle L. Ziegler ◽  
Alvin P. Shapiro ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Renal Involvement ◽  
Progressive Systemic Sclerosis

Atrial natriuretic peptide – cyclic GMP coupling and urinary sodium excretion during acute volume expansion in man

1990 ◽  
Vol 68 (4) ◽  
pp. 535-538 ◽  
Author(s):  
Giuseppe A. Sagnella ◽  
Donald R. J. Singer ◽  
Nirmala D. Markandu ◽  
Graham A. MacGregor ◽  
David G. Shirley ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Cyclic Gmp ◽  
Sodium Excretion ◽  
Volume Expansion ◽  
Isotonic Saline ◽  
Urinary Sodium Excretion ◽  
Urinary Sodium ◽  
Saline Infusion ◽  
Atrial Natriuretic

The present study examines hormonal and renal responses to acute volume expansion in normal man, with particular emphasis on the atrial natriuretic peptide (ANP) – cyclic GMP coupling. Two liters of isotonic saline were infused into eight normotensive male subjects over a 1-h period. Plasma and urinary measurements were made before, during, and up to 300 min after the start of the saline infusion. With the initial increase in urinary sodium excretion there were increases in plasma ANP and plasma cyclic GMP, which reached maximum levels at 15 min after the end of the saline infusion. Urinary cyclic GMP increased gradually during saline infusion up to approximately 60 min after the end of the infusion. Plasma ANP and plasma and urinary cyclic GMP excretion gradually declined thereafter. By contrast, urinary sodium excretion remained elevated up to the end of the observation period. The saline infusion was associated with marked reductions in plasma renin activity and aldosterone, which persisted up to the end of the study. These results suggest a coupling between the increases in plasma ANP, the production of cyclic GMP, and urinary sodium excretion, in particular during the initial renal response to acute volume expansion. However, other mechanisms including the suppression of the rennin–angiotensin–aldosterone system may become increasingly important in the later natriuretic response to acute volume expansion.Key words: atrial natriuretic peptide, cyclic GMP, sodium, renal, human.

scholarly journals Urodilatin, a kidney-derived natriuretic factor, is excreted with a circadian rhythm and is stimulated by saline infusion in man.

1991 ◽  
Vol 1 (9) ◽  
pp. 1109-1113
Author(s):  
C Drummer ◽  
F Fiedler ◽  
A König ◽  
R Gerzer
Keyword(s):  
Circadian Rhythm ◽  
Sodium Excretion ◽  
Isotonic Saline ◽  
Physiological Role ◽  
Urinary Sodium Excretion ◽  
Saline Infusion ◽  
Sodium Homeostasis ◽  
Peptide Family ◽  
Physiological Regulator

Urodilatin is a recently described, presumably kidney-derived member of the atrial natriuretic peptide family. The first data on a physiological role for urodilatin in the regulation of sodium homeostasis in humans is presented in this work. Urinary urodilatin excretion during a 9-day study in healthy volunteers paralleled the circadian rhythm in urinary sodium excretion. Furthermore, urodilatin and sodium excretion were slightly increased during the first 3 h after an acute isotonic saline infusion and about three-fold elevated during 14 h postinfusion; both parameters remained closely correlated up to 28 h postinfusion. These data suggest that urodilatin is involved in the circadian regulation of sodium excretion and is a physiological regulator of long-term sodium excretion after an acute saline infusion.

Natriuretic Response to Preferential Plasma Volume Expansion in Normal Unanaesthetized Dogs

1971 ◽  
Vol 40 (1) ◽  
pp. 73-79 ◽  
Author(s):  
J. A. Reyburn ◽  
J. P. Gilmore
Keyword(s):  
Plasma Volume ◽  
Sodium Excretion ◽  
Volume Expansion ◽  
Isotonic Saline ◽  
Urine Flow ◽  
Saline Infusion ◽  
Potassium Excretion ◽  
Plasma Volume Expansion ◽  
Volume Increase

1. The natriuretic response of normally hydrated unanaesthetized dogs to preferential plasma volume expansion was studied, comparing the response to infusion of hyperoncotic dextran in isotonic saline with that to infusion of an identical volume of isotonic saline. 2. Significant increases in urine flow, sodium excretion, sodium filtration and potassium excretion were observed with each type of infusion. 3. The changes with each type of infusion were not significantly different however, even though plasma volume increased significantly following dextran saline infusion. 4. The natriuretic response of normal dogs to preferential plasma volume expansion appears to be commensurate with the saline load infused rather than the induced plasma volume increase.

Response of Patients with Renal Involvement by Progressive Systemic Sclerosis to Antihypertensive Therapy

1981 ◽  
Vol 61 (s7) ◽  
pp. 395s-398s ◽  
Author(s):  
Y. M. Traub ◽  
A. P. Shapiro ◽  
T. A. Osial ◽  
G. P. Rodnan ◽  
T. A. Medsger ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Antihypertensive Therapy ◽  
Renal Involvement ◽  
Progressive Systemic Sclerosis ◽  
Early Death ◽  
Plasma Renin ◽  
Angiotensin Converting Enzyme Inhibition ◽  
Hypertensive Retinopathy ◽  
Converting Enzyme Inhibition ◽  
Rapidly Progressive Renal Failure

1. Renal involvement in progressive systemic sclerosis is characterized by hypertension, grade III or IV hypertensive retinopathy, rapidly progressive renal failure and enhanced plasma renin activity. 2. Of 70 patients with progressive systemic sclerosis involving the kidneys seen since 1955, 48 died within less than 3 months and 16 are alive or survived longer than 1 year. 3. Aggressive antihypertensive therapy was the principal factor that prevented early death in the 16 survivors. 4. Angiotensin converting enzyme inhibition with captopril appears to be the treatment of choice at present, but methyldopa or minoxidil may be successful in certain patients whose response to captopril is not satisfactory.

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