scholarly journals Periosteal new bone formation in polyarteritis nodosa. A syndrome involving the lower extremities

1974 ◽  
Vol 17 (6) ◽  
pp. 1017-1025 ◽  
Author(s):  
Anthony H. Woodward ◽  
Paul H. Andreini
Keyword(s):  
Bone Formation ◽  
Polyarteritis Nodosa ◽  
Lower Extremities ◽  
New Bone Formation ◽  
Periosteal New Bone Formation

scholarly journals A Comprehensive Clinicopathologic Analysis Suggests that Vascular Endothelial Growth Factor (VEGF) is the Most Likely Mediator of Periosteal New Bone Formation (PNBF) Associated with Diverse Etiologies

2008 ◽  
Vol 1 ◽  
pp. CMAMD.S442
Author(s):  
Meredith A. Lakey ◽  
Michael J. Klein ◽  
Ona M. Faye-Petersen
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Bone Formation ◽  
Fracture Repair ◽  
Prostaglandin E ◽  
Hypertrophic Osteoarthropathy ◽  
Vascular Endothelial ◽  
New Bone Formation ◽  
Endothelial Growth Factor ◽  
Periosteal New Bone Formation

Periosteal new bone formation (PNBF) is the means by which appositional bone growth normally takes place on the surfaces of compact bone. Alterations in the periosteal microenvironment trigger complex interactions between osteoblasts and endothelial cells to promote PNBF. Physiologic processes like mechanical stress result in normal PNBF; but, a variety of pathologic processes result in excessive PNBF. The production of sufficient bone to be detectable by conventional radiography is a common feature of diverse etiologies, including infection; inflammation; prostaglandin E2 administration for ductal-dependent congenital heart disease; metabolic and hormonal abnormalities; neoplasms; fracture repair; systemic hypoxia; and hypertrophic osteoarthropathy. While the clinical settings and distribution of affected bone sites in these conditions are different, the histopathology of the PNBF is essentially identical; so, it seems logical that a common pathway might mediate them all. By combining the observations and insights gained from osseous research and studying the clinical pathology of these diverse conditions, we constructed a comprehensive pathway to explain PNBF. In doing so, it seems likely that Vascular Endothelial Growth Factor (VEGF) is the most likely common mediator of the pathways that lead to PNBF.

scholarly journals  Hypertrophic osteopathy in a dog associated with intra-thoracic lesions: a case report and a review

2011 ◽  
Vol 56 (No. 12) ◽  
pp. 595-601 ◽  
Author(s):  
MA Cetinkaya ◽  
B. Yardimci ◽  
C. Yardimci
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Bone Formation ◽  
Disease Process ◽  
Radical Mastectomy ◽  
New Bone Formation ◽  
Cross Sectional ◽  
Hind Limbs ◽  
Metatarsal Bones ◽  
Periosteal New Bone Formation

This paper reviews hypertrophic osteopathy and describes one case report. Hypertrophic osteopathy is a rare pathologic disease process and is observed secondary to a mass in the thorax. In response to the presence of a mass(es), nonoedematous soft tissue swellings and a diffuse periosteal new bone formation develop in all four limbs. The result is mild to severe lameness. A twelve-year-old sexually intact female Cocker spaniel had undergone radical mastectomy on both sides in another veterinary hospital about two years before presentation in our hospital with lameness of both hind limbs. Pain and soft tissue swelling on the distal parts of extremities were determined in clinical examinations. Radiographs revealed periosteal new bone formation on all the long bones of all four limbs, pelvis and sternum; additionally, intrathoracic masses were observed. Euthanasia was performed five months later. Macroscopic examinations of the lungs revealed diffuse and exuberant masses with grizzled whitish cross-sectional colour and with necrotic and haemorrhagic foci. The radius-ulna, tibia, metacarpal and metatarsal bones of both limbs were examined and collected after the necropsy examination. Bone specimens were thicker and the outer surfaces seemed to be rough. At the histopathologic examination of the lung tissue, ovoid or round shaped and hyperchromatic nucleated diffuse anaplastic mammary gland epithelial cells were observed. According to these findings, these masses were diagnosed as the metastasis of malignant mixed tumours.  

Periosteal new bone formation in a canine neuropathic model of osteoarthritis

1997 ◽  
Vol 40 (10) ◽  
pp. 1756-1759 ◽  
Author(s):  
Stephen L. Myers ◽  
Kenneth D. Brandt ◽  
Brian O'Connor ◽  
William R. Widmer ◽  
Marjorie Albrecht
Keyword(s):  
Bone Formation ◽  
New Bone Formation ◽  
Periosteal New Bone Formation

Periosteal new bone formation in chronic renal failure

1989 ◽  
Vol 40 (5) ◽  
pp. 490-493 ◽  
Author(s):  
A.P. Parnell ◽  
W. Simpson ◽  
M.K. Ward
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Bone Formation ◽  
New Bone Formation ◽  
Periosteal New Bone Formation

Soft-tissue haemangioma and periosteal new bone formation on the neighbouring bone

2001 ◽  
Vol 121 (10) ◽  
pp. 549-553 ◽  
Author(s):  
T. Goto ◽  
T. Kojima ◽  
T. Iijima ◽  
S. Yokokura ◽  
H. Kawano ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Formation ◽  
New Bone Formation ◽  
Periosteal New Bone Formation

Neonatal Cortical Hyperostosis

2000 ◽  
Vol 19 (7) ◽  
pp. 55-57
Author(s):  
Barbara Carey
Keyword(s):  
Bone Formation ◽  
Diagnostic Imaging ◽  
Heart Defects ◽  
Timing Of Surgery ◽  
Optimal Timing ◽  
New Bone Formation ◽  
Optimal Stabilization ◽  
Bone Changes ◽  
Cortical Hyperostosis ◽  
Periosteal New Bone Formation

PROSTAGLANDIN THERAPY FOR neonates with ductal-dependent heart defects is a lifesaving intervention that permits optimal stabilization, diagnostic imaging, and timing of surgery. However, this therapy is not without complications (Table 1).1–3 When longterm (weeks or months) prostaglandin therapy is required because of neonatal immaturity or for optimal timing of procedures, one complication that may occur is bone changes: cortical hyperostosis/ periosteal new-bone formation.2,4

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