scholarly journals Does activation of the innate immune system contribute to the development of rheumatoid arthritis?

2003 ◽  
Vol 48 (3) ◽  
pp. 590-593 ◽  
Author(s):  
Dennis Klinman
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune System ◽  
Innate Immune System ◽  
Innate Immune

scholarly journals Mast Cell and Autoimmune Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Yunzhi Xu ◽  
Guangjie Chen
Keyword(s):  
Rheumatoid Arthritis ◽  
Multiple Sclerosis ◽  
Mast Cell ◽  
Immune System ◽  
Mast Cells ◽  
Autoimmune Diseases ◽  
Innate Immune System ◽  
Innate Immune ◽  
Current Stage

Mast cells are important in innate immune system. They have been appreciated as potent contributors to allergic reaction. However, increasing evidence implicates the important role of mast cells in autoimmune disease like rheumatoid arthritis and multiple sclerosis. Here we review the current stage of knowledge about mast cells in autoimmune diseases.

scholarly journals Rheumatoid arthritis and systemic lupus erythematosus: Pathophysiological mechanisms related to innate immune system

2019 ◽  
Vol 7 ◽  
pp. 205031211987614 ◽  
Author(s):  
Maria Angélica Pabón-Porras ◽  
Sebastian Molina-Ríos ◽  
Jorge Bruce Flórez-Suárez ◽  
Paola Ximena Coral-Alvarado ◽  
Paul Méndez-Patarroyo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Immune Response ◽  
Immune System ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Innate Immune System ◽  
Normal Function ◽  
Innate Immune ◽  
Systemic Lupus

Rheumatoid arthritis and systemic lupus erythematosus are two highly prevalent autoimmune diseases that generate disability and low quality of life. The innate immune system, a long-forgotten issue in autoimmune diseases, is becoming increasingly important and represents a new focus for the treatment of these entities. This review highlights the role that innate immune system plays in the pathophysiology of rheumatoid arthritis and systemic lupus erythematosus. The role of the innate immune system in rheumatoid arthritis and systemic lupus erythematosus pathophysiology is not only important in early stages but is essential to maintain the immune response and to allow disease progression. In rheumatoid arthritis, genetic and environmental factors are involved in the initial stimulation of the innate immune response in which macrophages are the main participants, as well as fibroblast-like synoviocytes. In systemic lupus erythematosus, all the cells contribute to the inflammatory response, but the complement system is the major effector of the inflammatory process. Detecting alterations in the normal function of these cells, besides its contribution to the understanding of the pathophysiology of autoimmune diseases, could help to establish new treatment strategies for these diseases.

scholarly journals The effect of anti-TNF inhibitors on innate immune system in synovial tissues in rheumatoid arthritis patients

2016 ◽  
Vol 7 ◽  
pp. 120
Author(s):  
Yuya Takakubo ◽  
Hiroharu Oki ◽  
Yasushi Naganuma ◽  
Suran Yang ◽  
Nomi Hanaka ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune System ◽  
Innate Immune System ◽  
Tnf Inhibitors ◽  
Innate Immune ◽  
Synovial Tissues
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