scholarly journals Bcl-3 is an interleukin-1-responsive gene in chondrocytes and synovial fibroblasts that activates transcription of the matrix metalloproteinase 1 gene

2002 ◽  
Vol 46 (12) ◽  
pp. 3230-3239 ◽  
Author(s):  
Sarah F. Elliott ◽  
Charles I. Coon ◽  
Ezra Hays ◽  
Terrance A. Stadheim ◽  
Matthew P. Vincenti
Keyword(s):  
Matrix Metalloproteinase ◽  
Interleukin 1 ◽  
Synovial Fibroblasts ◽  
Matrix Metalloproteinase 1 ◽  
The Matrix ◽  
Responsive Gene

scholarly journals Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1)

1998 ◽  
Vol 331 (1) ◽  
pp. 341-346 ◽  
Author(s):  
Matthew P. VINCENTI ◽  
Charles I. COON ◽  
J. Andrew MENGSHOL ◽  
Sue YOCUM ◽  
Peter MITCHELL ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Time Course ◽  
Interleukin 1 ◽  
Connective Tissue Diseases ◽  
Synovial Fibroblasts ◽  
Matrix Metalloproteinase 1 ◽  
Rabbit Gene ◽  
Factor Α ◽  
Interstitial Collagenase

Cartilage, bone and the interstitial stroma, composed largely of the interstitial collagens, types I, II and III, are remodelled by three members of the metalloproteinase (MMP) family, collagenase-1 (MMP-1), collagenase-2 (MMP-8) and collagenase-3 (MMP-13). MMP-1 and MMP-13 may contribute directly to disease progression, since they are induced in patients with rheumatoid arthritis and osteoarthritis. The study of MMP-1 and MMP-13 gene regulation in models of arthritic disease has been problematic because mice and rats, which are typically used, only possess a homologue of MMP-13. Here we show that in contrast with mice and rats, rabbits possess distinct genes homologous to human MMP-1 and MMP-13. Furthermore, rabbit MMP-13 is expressed simultaneously with MMP-1 in chondrocytes and synovial fibroblasts in response to the cytokines interleukin-1 and tumour necrosis factor-α, or the phorbol ester PMA. The time course of MMP-13 induction is more rapid and transient than that of MMP-1, suggesting that distinct mechanisms regulate the expression of these two collagenases. We have cloned the rabbit MMP-13 gene from synovial fibroblasts and demonstrated that the rabbit gene shares greater homology with human MMP-13 than does the mouse interstitial collagenase. Together with the fact that mice and rats do not possess a homologue to human MMP-1, our data suggest that the rabbit provides an appropriate model for studying the roles of interstitial collagenases in connective-tissue diseases, such as rheumatoid arthritis and osteoarthritis.

The development of a matrix metalloproteinase-1 biosensor based on the surface plasmon resonance imaging technique

2016 ◽  
Vol 8 (34) ◽  
pp. 6428-6435 ◽  
Author(s):  
Anna Tokarzewicz ◽  
Lech Romanowicz ◽  
Iosif Sveklo ◽  
Ewa Gorodkiewicz
Keyword(s):  
Surface Plasmon Resonance ◽  
Matrix Metalloproteinase ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Detection Method ◽  
Imaging Technique ◽  
Surface Plasmon Resonance Imaging ◽  
Matrix Metalloproteinase 1 ◽  
The Matrix

The purpose of this study was to create a new, highly selective biosensor, which uses surface plasmon resonance as a detection method for the quantitative determination of the matrix metalloproteinase-1.

Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China

2007 ◽  
Vol 85 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Zhongqiang Lu ◽  
Yanyan Cao ◽  
Yimin Wang ◽  
Qingjun Zhang ◽  
Xianghong Zhang ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Northern China ◽  
Matrix Metalloproteinase 1 ◽  
The Matrix
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