scholarly journals Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial

2002 ◽  
Vol 46 (12) ◽  
pp. 3143-3150 ◽  
Author(s):  
E. H. S. Choy ◽  
D. A. Isenberg ◽  
T. Garrood ◽  
S. Farrow ◽  
Y. Ioannou ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Monoclonal Antibody ◽  
Dose Escalation ◽  
Interleukin 6 ◽  
Therapeutic Benefit ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Interleukin 6 Receptor ◽  
Receptor Monoclonal Antibody

scholarly journals Use of tocilizumab in the combination treatment of a COVID-19 patient with concomitant rheumatoid arthritis (a case report)

2021 ◽  
Vol 23 (5) ◽  
pp. 739-748
Author(s):  
V. A. Vizir ◽  
A. S. Sadomov ◽  
O. V. Demidenko
Keyword(s):  
Rheumatoid Arthritis ◽  
Monoclonal Antibody ◽  
Combination Treatment ◽  
Interleukin 6 ◽  
Clinical Case ◽  
Clinical Laboratory ◽  
Cytokine Storm ◽  
X Ray ◽  
Interleukin 6 Receptor ◽  
Receptor Monoclonal Antibody

The aim is to familiarize practitioners with the clinical case of tocilizumab use in the combination treatment of the coronavirus disease (COVID-19) patient with concomitant rheumatoid arthritis. Materials and methods. The clinical case shows our own follow-up of COVID-19 clinical course in the patient with concomitant rheumatoid arthritis during combination treatment with the use of a recombinant humanized anti-interleukin-6 receptor monoclonal antibody tocilizumab. Results. The patient with a severe COVID-19 course, whose examination and treatment results are given in the article, was comorbid for rheumatoid arthritis. The cytokine storm development at the hospital stage was confirmed by an increase in markers of systemic inflammation: C-reactive protein, D-dimer, fibrinogen, an almost 50-fold increase in serum interleukin-6 level, as well as absolute and relative lymphocytopenia. Despite the anti-inflammatory therapy administered with systemic corticosteroids, the patient’s condition progressively worsened. After assessing the indications and contraindications, it was decided to use the interleukin-6 receptor inhibitor tocilizumab, followed by rapid clinical, laboratory and X-ray positive response to the treatment. The understanding of tocilizumab use in patients with COVID-19 at the current stage was formed based on the comparative analysis of our own clinical case data and the results of relevant clinical trials, world recommendations and guidelines. Conclusions. The use of recombinant humanized anti-interleukin-6 receptor monoclonal antibody tocilizumab in the combination treatment of severe COVID-19 with concomitant rheumatoid arthritis is pathogenetically based and decreases the main clinical and laboratory signs of cytokine storm, respiratory failure, improves chest x-ray findings and reduces the length of hospital stay. Further large randomized placebo-controlled trials including the population of patients with various comorbid conditions are needed to clarify conclusively the place and role of anti-cytokine drugs in the treatment of COVID-19 patients.

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

The Lancet ◽  
2008 ◽  
Vol 371 (9617) ◽  
pp. 987-997 ◽  
Author(s):  
Josef S Smolen ◽  
Andre Beaulieu ◽  
Andrea Rubbert-Roth ◽  
Cesar Ramos-Remus ◽  
Josef Rovensky ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 6 ◽  
Randomised Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Receptor Inhibition ◽  
Interleukin 6 Receptor

Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial

2004 ◽  
Vol 50 (6) ◽  
pp. 1761-1769 ◽  
Author(s):  
Norihiro Nishimoto ◽  
Kazuyuki Yoshizaki ◽  
Nobuyuki Miyasaka ◽  
Kazuhiko Yamamoto ◽  
Shinichi Kawai ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 6 ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Receptor Antibody ◽  
Interleukin 6 Receptor
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