Autoimmune responses to proliferating cell nuclear antigen multiprotein complexes involved in cell proliferation are strongly associated with their structure and biologic function in patients with systemic lupus erythematosus

2002 ◽  
Vol 46 (11) ◽  
pp. 2946-2956 ◽  
Author(s):  
Toshiaki Kogure ◽  
Yoshinari Takasaki ◽  
Ken Takeuchi ◽  
Hirofumi Yamada ◽  
Masuyuki Nawata ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cell Proliferation ◽  
Lupus Erythematosus ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Systemic Lupus ◽  
Multiprotein Complexes ◽  
Biologic Function ◽  
Proliferating Cell

scholarly journals Survivorship in systemic lupus erythematosus. effect of antibody to extractable nuclear antigen

1981 ◽  
Vol 24 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Marc C Hochberg ◽  
Carole A Dorsch ◽  
Edward J Feinglass ◽  
Mary Betty Stevens
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Nuclear Antigen ◽  
Systemic Lupus ◽  
Extractable Nuclear Antigen

scholarly journals Proliferating cell nuclear antigen (PCNA): a new marker to study human colonic cell proliferation.

Gut ◽  
1994 ◽  
Vol 35 (4) ◽  
pp. 530-535 ◽  
Author(s):  
F J Kubben ◽  
A Peeters-Haesevoets ◽  
L G Engels ◽  
C G Baeten ◽  
B Schutte ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Proliferating Cell

scholarly journals Immunological and Clinical Characteristics of Systemic Lupus Erythematosus: A Series from Morocco

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Zeineb Zian ◽  
Mouna Maamar ◽  
Mohamed El Aouni ◽  
Amina Barakat ◽  
Naima Ghailani Nourouti ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Arab Countries ◽  
University Hospital ◽  
Nuclear Antigen ◽  
Systemic Lupus ◽  
Female Predominance ◽  
Dna Antibodies ◽  
Moroccan Patients

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with a high female predominance. To date, studies about SLE in Morocco are few. This retrospective study describes the clinical and immunological features in a series of 50 SLE Moroccan patients in University Hospital Center of Rabat, Morocco, between December 2011 and December 2013. All patients were screened for antinuclear antibodies (ANA) and anti-DNA antibodies by indirect immunofluorescence, followed by identification of anti-extractable nuclear antigen antibodies by ELISA. The female to male ratio was 6.1:1. Mean age was 31.72 years. The main clinical manifestations were arthritis (82%), mucocutaneous manifestations (80%), renal manifestations (50%), and hematological features (46%). Of the mucocutaneous features, the highest frequencies were observed in the malar rash (68%) and photosensitivity (60%). Of the hematological features, lymphopenia was most frequently observed in 30% of patients, followed by hemolytic anemia in 16% and leucopenia and thrombocytopenia in 8%. Central nervous system was involved in 10%. ANA were found in 88%, anti-DNA antibodies in 56%, and anti-Sm antibodies in 50%. Anti-SSA, anti-SSB, anti-Sm/RNP, and anti-Scl70 antibodies were detected in 38%, 10%, 48%, and 8%, respectively. Our data show that, in our patients, the main clinical and immunological features of SLE remain comparable to patients from other Arab countries.

Sign in / Sign up

Export Citation Format

Share Document