scholarly journals Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes

2002 ◽  
Vol 46 (11) ◽  
pp. 2867-2877 ◽  
Author(s):  
Malini Sen ◽  
Jack Reifert ◽  
Kevin Lauterbach ◽  
Vladimir Wolf ◽  
Jeffrey S. Rubin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Wnt Signaling ◽  
Rheumatoid Arthritis Synoviocytes

scholarly journals The Regulation of Bone Metabolism and Disorders by Wnt Signaling

2019 ◽  
Vol 20 (22) ◽  
pp. 5525 ◽  
Author(s):  
Kazuhiro Maeda ◽  
Yasuhiro Kobayashi ◽  
Masanori Koide ◽  
Shunsuke Uehara ◽  
Masanori Okamoto ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Wnt Signaling ◽  
Bone Metabolism ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Osteoporosis Treatment ◽  
Biological Phenomena ◽  
Approximate Molecular Weight ◽  
Skeletal Disorders ◽  
Canonical Wnt

Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a cytokine involved in various biological phenomena including ontogeny, morphogenesis, carcinogenesis, and maintenance of stem cells. The Wnt signaling pathway can be classified into two main pathways: canonical and non-canonical. Of these, the canonical Wnt signaling pathway promotes osteogenesis. Sclerostin produced by osteocytes is an inhibitor of this pathway, thereby inhibiting osteogenesis. Recently, osteoporosis treatment using an anti-sclerostin therapy has been introduced. In this review, the basics of Wnt signaling, its role in bone metabolism and its involvement in skeletal disorders have been covered. Furthermore, the clinical significance and future scopes of Wnt signaling in osteoporosis, osteoarthritis, rheumatoid arthritis and neoplasia are discussed.

scholarly journals TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes

2014 ◽  
Vol 50 ◽  
pp. 59-66 ◽  
Author(s):  
Sinisa Savic ◽  
Lylia Ouboussad ◽  
Laura J. Dickie ◽  
Janina Geiler ◽  
Chi Wong ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Autocrine Loop ◽  
Rheumatoid Arthritis Synoviocytes

A1.19 Zinc and cadmium homeostasis is altered in rheumatoid arthritis synoviocytes

2014 ◽  
Vol 73 (Suppl 1) ◽  
pp. A8.1-A8
Author(s):  
Paola Bonaventura ◽  
Fabien Lavocat ◽  
Giulia Benedetti ◽  
Aline Lambroux ◽  
Francis Albarede ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Arthritis Synoviocytes

scholarly journals Chemical variability of Rhododendron tomentosum (Ledum palustre) essential oils and their pro-apoptotic effect on lymphocytes and rheumatoid arthritis synoviocytes

Fitoterapia ◽  
2019 ◽  
Vol 139 ◽  
pp. 104402 ◽  
Author(s):  
Anna Jesionek ◽  
Adam Kokotkiewicz ◽  
Anna Mikosik-Roczynska ◽  
Klaudia Ciesielska-Figlon ◽  
Piotr Luczkiewicz ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Essential Oils ◽  
Ledum Palustre ◽  
Chemical Variability ◽  
Apoptotic Effect ◽  
Rheumatoid Arthritis Synoviocytes ◽  
Rhododendron Tomentosum

scholarly journals Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Geng Yin ◽  
Ying Wang ◽  
Xiao-min Cen ◽  
Min Yang ◽  
Yan Liang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cell Apoptosis ◽  
Inflammatory Responses ◽  
Synovial Fibroblasts ◽  
Systemic Autoimmune Disease ◽  
New Strategy ◽  
Significant Clinical Improvement ◽  
Rheumatoid Arthritis Synoviocytes ◽  
Initiation Of Therapy

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints. The central pathogenesis of RA is the proliferation of synovial fibroblasts in response to inflammatory cytokines. However, some of the targeted therapies for inflammation reactions do not display significant clinical improvement after initiation of therapy. Thus, the relationship between inflammatory responses and RA therapy is still incompletely understood. In the present study, we proposed to determine whether enhanced inflammations may lead to cell apoptosis in rheumatoid arthritis synoviocytes. Our results indicated that products of lipid peroxidations, 4-HNE, may induce synovial intrinsic inflammations by activating NF-κB pathways and it may lead to cell apoptosis. Pharmacological inhibition of NF-κB activation may reduce the 4-HNE mediated inflammation responses and subsequent cell apoptosis. Our results may help to clarify the role of inflammations on RA development and imply that blocking NF-κB activation may be partly beneficial for human RA therapy. These findings might provide a mechanism-based rationale for developing new strategy to RA clinical therapy.

Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling

2013 ◽  
Vol 25 (10) ◽  
pp. 2069-2078 ◽  
Author(s):  
Cheng-gui Miao ◽  
Ying-ying Yang ◽  
Xu He ◽  
Xiao-feng Li ◽  
Cheng Huang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Wnt Signaling ◽  
Bone Remodeling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Synovial Inflammation

scholarly journals Responsiveness of human T lymphocytes to bacterial superantigens presented by cultured rheumatoid arthritis synoviocytes

1996 ◽  
Vol 39 (1) ◽  
pp. 125-136 ◽  
Author(s):  
Carlene Tsai ◽  
Luis A. Diaz ◽  
Nora G. Singer ◽  
Lan Lan Li ◽  
Anita H. Kirsch ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Lymphocytes ◽  
Human T Lymphocytes ◽  
Rheumatoid Arthritis Synoviocytes ◽  
Bacterial Superantigens
Sign in / Sign up

Export Citation Format

Share Document