scholarly journals Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: A population-based, case-control study in the Southeastern United States

2002 ◽  
Vol 46 (7) ◽  
pp. 1840-1850 ◽  
Author(s):  
Christine G. Parks ◽  
Glinda S. Cooper ◽  
Leena A. Nylander-French ◽  
Wayne T. Sanderson ◽  
John M. Dement ◽  
...  
Keyword(s):  
United States ◽  
Systemic Lupus Erythematosus ◽  
Occupational Exposure ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Southeastern United States ◽  
Population Based ◽  
Case Control ◽  
Systemic Lupus ◽  
Control Study

scholarly journals Clinically diagnosed urticaria and risk of systemic lupus erythematosus in children: A nationwide population-based case-control study

2018 ◽  
Vol 29 (7) ◽  
pp. 732-739 ◽  
Author(s):  
Chien-Hung Lin ◽  
Peir-Haur Hung ◽  
Hsiao-Yun Hu ◽  
Chi-Jung Chung ◽  
Tsung-Hsien Chen ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Systemic Lupus ◽  
Control Study

scholarly journals Explore comorbidities associated with systemic lupus erythematosus: a total population-based case–control study

QJM ◽  
2020 ◽  
Author(s):  
J -H Chen ◽  
C T -C Lee
Keyword(s):  
Diabetes Mellitus ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Total Population ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Systemic Lupus ◽  
Multiple Organs ◽  
Control Study

Summary Background Because of the increasing incidence and overall burden of systemic lupus erythematosus (SLE), efforts have been made to identify the factors that contribute to SLE onset and progression. Aim We conducted a total population-based case–control study to explore the prior comorbidities associated with SLE. Design and methods Data were collected from Taiwan’s National Health Insurance Research Database. Newly diagnosed SLE patients from 1 January 2010, to 31 December 2013 (n = 2847), were exactly matched at a 1:4 ratio for gender, age, residence and insurance premium to form a non-SLE group. Multivariate conditional logistic regression with stepwise selection was used to find the prior-associated comorbidities. Results A total of 38 prior comorbidities were associated with SLE incidence (32 positive and 6 negative associations). Positively associated comorbidities could be categorized as autoimmune-related inflammation of multiple organs including skin, blood, liver, tooth, thyroid, musculoskeletal and connective tissue. Among them, diffuse diseases of connective tissue (International Classification of Disease, Ninth Revision, Clinical Modification 710) exhibited the most robust association (OR = 5.68, 95% CI = 4.02–8.03, P < 0.001) in the 5 years before the index date. Negatively associated comorbidities could be attributed to diabetes mellitus and pregnancy related symptoms. Conclusions Our results supported that increased awareness of SLE may be warranted for patients with autoimmune-related comorbidities of multiple organs. However, diabetes mellitus and pregnancy related symptoms were negatively associated with SLE incidence in this study. Further studies are warranted to elucidate the possible underlying mechanism and for better understanding the pathogenesis of SLE.

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