scholarly journals Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope

2002 ◽  
Vol 46 (7) ◽  
pp. 1937-1946 ◽  
Author(s):  
Berent J. Prakken ◽  
Sarah Roord ◽  
Peter J. S. Van Kooten ◽  
Jos�e P. A. Wagenaar ◽  
Willem Van Eden ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Epitope ◽  
Interleukin 10 ◽  
Nasal Administration ◽  
Heat Shock Protein 60 ◽  
T Cell Epitope ◽  
Regulatory Cells ◽  
Peptide Analog ◽  
Adjuvant Induced Arthritis

A conjugate vaccine composed of a heat shock protein 60 T-cell epitope peptide (p458) and Neisseria meningitidis type B capsular polysaccharide

Vaccine ◽  
2006 ◽  
Vol 24 (42-43) ◽  
pp. 6555-6563 ◽  
Author(s):  
Hila Amir-Kroll ◽  
Luis Riveron ◽  
Maria E. Sarmiento ◽  
Gustavo Sierra ◽  
Armando Acosta ◽  
...  
Keyword(s):  
T Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Neisseria Meningitidis ◽  
Capsular Polysaccharide ◽  
Cell Epitope ◽  
Heat Shock Protein 60 ◽  
T Cell Epitope ◽  
Type B ◽  
Epitope Peptide

scholarly journals Cellular and Molecular Regulation of Vaccination with Heat Shock Protein 60 from Histoplasma capsulatum

2002 ◽  
Vol 70 (7) ◽  
pp. 3759-3767 ◽  
Author(s):  
George S. Deepe ◽  
Reta S. Gibbons
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Histoplasma Capsulatum ◽  
Regulatory Elements ◽  
Interleukin 10 ◽  
Gamma Interferon ◽  
Yeast Cells ◽  
Heat Shock Protein 60 ◽  
Fungal Burden ◽  
Inductive Phase

ABSTRACT Vaccination with heat shock protein 60 (Hsp60) from Histoplasma capsulatum induces a protective immune response in mice. We explored the cellular and molecular requirements for the efficacy of recombinant Hsp60 in mice. Depletion of CD4+, but not CD8+, cells during the inductive phase of vaccination abolished protection, as assessed by survival and by the fungal burden in lungs and spleens. In the expressive phase, the elimination of CD4+ or CD8+ cells after immunization did not significantly alter fungal recovery or survival from a lethal challenge. Depletion of both subpopulations after Hsp60 vaccination resulted in a failure to control a lethal infection and a higher fungal burden in lungs and spleens. Cytokine release by spleen cells from mice vaccinated with Hsp60 produced substantially more gamma interferon and interleukin-10 and -12 than that of cells from mice immunized with either H. capsulatum recombinant Hsp70 or bovine serum albumin. The generation of gamma interferon, but not of interleukin-10, was dependent on T cells, in particular CD4+ cells. Treatment of Hsp60-immunized mice with monoclonal antibody to gamma interferon or interleukin-10 or -12 in the inductive phase of vaccination was accompanied by increased recovery of yeast cells from lungs and spleens and 100% mortality. Likewise, the neutralization of gamma interferon or interleukin-12 abolished the protective effect of Hsp60 in the expressive phase. These results delineate the complexity of the regulatory elements necessary for vaccination against this fungus.

scholarly journals Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 ◽  
Vol 88 (8) ◽  
pp. 3088-3091 ◽  
Author(s):  
D. Elias ◽  
T. Reshef ◽  
O. S. Birk ◽  
R. van der Zee ◽  
M. D. Walker ◽  
...  
Keyword(s):  
T Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Epitope ◽  
T Cell Epitope ◽  
Autoimmune Mouse
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