Novel ketoprofen–antioxidants mutual codrugs as safer nonsteroidal anti‐inflammatory drugs: Synthesis, kinetic and pharmacological evaluation

2019 ◽  
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Shikha Sehajpal ◽  
Deo Nandan Prasad ◽  
Rajesh K. Singh
1992 ◽  
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Maria Pires ◽  
Luiz Dutra ◽  
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Eleni A. Rekka ◽  
Panos N. Kourounakis

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A Figueirinha ◽  
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C Garcia-Rodriguez ◽  
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SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.


This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)


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