Irreversible Inhibitors of the Epidermal Growth Factor Receptor: Thienopyrimidine Core with α,β-Unsaturated Amide Side Chain

Xiu L. Yang; Tian C. Wang; Sen Lin; Hou X. Fan

doi:10.1002/ardp.201400098

Irreversible Inhibitors of the Epidermal Growth Factor Receptor: Thienopyrimidine Core with α,β-Unsaturated Amide Side Chain

Archiv der Pharmazie ◽

10.1002/ardp.201400098 ◽

2014 ◽

Vol 347 (8) ◽

pp. 552-558 ◽

Cited By ~ 1

Author(s):

Xiu L. Yang ◽

Tian C. Wang ◽

Sen Lin ◽

Hou X. Fan

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Side Chain ◽

Irreversible Inhibitors ◽

Epidermal Growth ◽

Amide Side Chain

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Discovery of Pteridin-7(8H)-one-Based Irreversible Inhibitors Targeting the Epidermal Growth Factor Receptor (EGFR) Kinase T790M/L858R Mutant

Journal of Medicinal Chemistry ◽

10.1021/jm401045n ◽

2013 ◽

Vol 56 (20) ◽

pp. 7821-7837 ◽

Cited By ~ 42

Author(s):

Wei Zhou ◽

Xiaofeng Liu ◽

Zhengchao Tu ◽

Lianwen Zhang ◽

Xin Ku ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Irreversible Inhibitors ◽

Epidermal Growth ◽

Egfr Kinase

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ChemInform Abstract: The Rationale and Strategy Used to Develop a Series of Highly Potent, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family of Tyrosine Kinases

ChemInform ◽

10.1002/chin.199946291 ◽

2010 ◽

Vol 30 (46) ◽

pp. no-no

Author(s):

A. J. Bridges

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinases ◽

Growth Factor Receptor ◽

Irreversible Inhibitors ◽

Epidermal Growth ◽

Receptor Family

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Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions.

Journal of Medicinal Chemistry ◽

10.1021/jm000250q ◽

2000 ◽

Vol 43 (16) ◽

pp. 3199-3199 ◽

Cited By ~ 4

Author(s):

Jeff B. Smaill ◽

Gordon W. Rewcastle ◽

Alexander J. Bridges ◽

Hairong Zhou ◽

H. D. Hollis Showalter ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Irreversible Inhibitors ◽

Epidermal Growth

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6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity

Journal of Medicinal Chemistry ◽

10.1021/jm0005555 ◽

2001 ◽

Vol 44 (17) ◽

pp. 2719-2734 ◽

Cited By ~ 189

Author(s):

Hwei-Ru Tsou ◽

Nellie Mamuya ◽

Bernard D. Johnson ◽

Marvin F. Reich ◽

Brian C. Gruber ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Antitumor Activity ◽

Tyrosine Kinases ◽

Growth Factor Receptor ◽

Human Epidermal Growth Factor ◽

Irreversible Inhibitors ◽

Her 2 ◽

Epidermal Growth

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Carbon-11 labeled irreversible inhibitors for mapping epidermal growth factor receptor tyrosine kinase (EGFR-TK)

Journal of Labelled Compounds and Radiopharmaceuticals ◽

10.1002/jlcr.2580440134 ◽

2001 ◽

Vol 44 (S1) ◽

pp. S99-S101 ◽

Cited By ~ 3

Author(s):

E. Mishani ◽

I. Ben-David ◽

Y. Rozen ◽

G. Ortu ◽

A. Leviztki

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Growth Factor Receptor ◽

Irreversible Inhibitors ◽

Epidermal Growth

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Epidermal Growth Factor Receptor Irreversible Inhibitors: Chemical Exploration of the Cysteine-Trap Portion

Mini-Reviews in Medicinal Chemistry ◽

10.2174/138955711797247725 ◽

2011 ◽

Vol 11 (12) ◽

pp. 1019-1030 ◽

Cited By ~ 36

Author(s):

C. Carmi ◽

A. Lodola ◽

S. Rivara ◽

F. Vacondio ◽

A. Cavazzoni ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Irreversible Inhibitors ◽

Epidermal Growth

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Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions

Journal of Medicinal Chemistry ◽

10.1021/jm990482t ◽

2000 ◽

Vol 43 (7) ◽

pp. 1380-1397 ◽

Cited By ~ 190

Author(s):

Jeff B. Smaill ◽

Gordon W. Rewcastle ◽

Joseph A. Loo ◽

Kenneth D. Greis ◽

O. Helen Chan ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Irreversible Inhibitors ◽

Epidermal Growth

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Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm9806603 ◽

1999 ◽

Vol 42 (10) ◽

pp. 1803-1815 ◽

Cited By ~ 130

Author(s):

Jeff B. Smaill ◽

Brian D. Palmer ◽

Gordon W. Rewcastle ◽

William A. Denny ◽

Dennis J. McNamara ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Binding Site ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Atp Binding Site ◽

Irreversible Inhibitors ◽

Epidermal Growth

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Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b00883 ◽

2016 ◽

Vol 59 (17) ◽

pp. 8103-8124 ◽

Cited By ~ 24

Author(s):

Jeff B. Smaill ◽

Andrea J. Gonzales ◽

Julie A. Spicer ◽

Helen Lee ◽

Jessica E. Reed ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Pyrimidine Derivatives ◽

Irreversible Inhibitors ◽

Epidermal Growth ◽

Orally Active ◽

Receptor Family

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High-Affinity Epidermal Growth Factor Receptor (EGFR) Irreversible Inhibitors with Diminished Chemical Reactivities as Positron Emission Tomography (PET)-Imaging Agent Candidates of EGFR Overexpressing Tumors

Journal of Medicinal Chemistry ◽

10.1021/jm0580196 ◽

2005 ◽

Vol 48 (16) ◽

pp. 5337-5348 ◽

Cited By ~ 53

Author(s):

Eyal Mishani ◽

Galith Abourbeh ◽

Orit Jacobson ◽

Samar Dissoki ◽

Revital Ben Daniel ◽

...

Keyword(s):

Positron Emission Tomography ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Emission Tomography ◽

High Affinity ◽

Irreversible Inhibitors ◽

Positron Emission ◽

Epidermal Growth

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