Synthesis and Biological Evaluation of Phenyl Substituted 1H-1,2,4-Triazoles as Non-Steroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 2

Yaseen A. Al-Soud; Sandrine Marchais-Oberwinkler; Martin Frotscher; Rolf W. Hartmann

doi:10.1002/ardp.201200025

Synthesis and Biological Evaluation of Phenyl Substituted 1H-1,2,4-Triazoles as Non-Steroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 2

Archiv der Pharmazie ◽

10.1002/ardp.201200025 ◽

2012 ◽

Vol 345 (8) ◽

pp. 610-621 ◽

Cited By ~ 11

Author(s):

Yaseen A. Al-Soud ◽

Sandrine Marchais-Oberwinkler ◽

Martin Frotscher ◽

Rolf W. Hartmann

Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of Spiro-δ-lactones as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2)

Letters in Drug Design & Discovery ◽

10.2174/157018011795514230 ◽

2011 ◽

Vol 8 (5) ◽

pp. 406-421 ◽

Cited By ~ 11

Author(s):

Kuiying Xu ◽

Marie Wetzel ◽

Rolf W. Hartmann ◽

Sandrine Marchais-Oberwinkler

Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of Thieno[3,2-d]- pyrimidinones, Thieno[3,2-d]pyrimidines and Quinazolinones: Conformationally Restricted 17b-Hydroxysteroid Dehydrogenase Type 2 (17b-HSD2) Inhibitors

Molecules ◽

10.3390/molecules18044487 ◽

2013 ◽

Vol 18 (4) ◽

pp. 4487-4509 ◽

Cited By ~ 5

Author(s):

Enrico Perspicace ◽

Sandrine Marchais-Oberwinkler ◽

Rolf Hartmann

Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Conformationally Restricted ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Synthesis and Biological Evaluation of Phenyl Substituted 1H-1,2,4-Triazoles as Non-Steroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 2.

ChemInform ◽

10.1002/chin.201248131 ◽

2012 ◽

Vol 43 (48) ◽

pp. no-no

Author(s):

Yaseen A. Al-Soud ◽

Sandrine Marchais-Oberwinkler ◽

Martin Frotscher ◽

Rolf W. Hartmann

Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5 H -thieno[3′,2’:3,4]pyrido[1,2- b ]isoquinolines as novel adenosine 5′-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.09.012 ◽

2017 ◽

Vol 140 ◽

pp. 448-464 ◽

Cited By ~ 8

Author(s):

Shengbin Zhou ◽

Yanan Duan ◽

Jiang Wang ◽

Jin Zhang ◽

Haifeng Sun ◽

...

Keyword(s):

Type 2 Diabetes ◽

Protein Kinase ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.09.048 ◽

2013 ◽

Vol 21 (23) ◽

pp. 7418-7429 ◽

Cited By ~ 14

Author(s):

Jiang Wang ◽

Ying Feng ◽

Xun Ji ◽

Guanghui Deng ◽

Ying Leng ◽

...

Keyword(s):

Type 2 Diabetes ◽

Dipeptidyl Peptidase ◽

Biological Evaluation ◽

Dipeptidyl Peptidase 4 ◽

Dipeptidyl Peptidase 4 Inhibitors ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Overview of a Rational Approach to Design Type I 17β-Hydroxysteroid Dehydrogenase Inhibitors Without Estrogenic Activity: Chemical Synthesis and Biological Evaluation

ChemInform ◽

10.1002/chin.199904257 ◽

2010 ◽

Vol 30 (4) ◽

pp. no-no

Author(s):

M. R. TREMBLAY ◽

D. POIRIER

Keyword(s):

Chemical Synthesis ◽

Estrogenic Activity ◽

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Rational Approach ◽

Type I ◽

Design Type ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: Discovery of YM543

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.03.067 ◽

2013 ◽

Vol 21 (13) ◽

pp. 3934-3948 ◽

Cited By ~ 26

Author(s):

Kazuhiro Ikegai ◽

Masakazu Imamura ◽

Takayuki Suzuki ◽

Keita Nakanishi ◽

Takeshi Murakami ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Biological Evaluation ◽

Sglt2 Inhibitors ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.04.120 ◽

2010 ◽

Vol 20 (12) ◽

pp. 3565-3568 ◽

Cited By ~ 6

Author(s):

Tang Peng Cho ◽

Yang Fang Long ◽

Lin Zhi Gang ◽

Wang Yang ◽

Lu He Jun ◽

...

Keyword(s):

Type 2 Diabetes ◽

Dipeptidyl Peptidase ◽

Biological Evaluation ◽

Dipeptidyl Peptidase 4 ◽

Dipeptidyl Peptidase 4 Inhibitors ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of picolinamides as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2014.11.074 ◽

2015 ◽

Vol 25 (3) ◽

pp. 695-700 ◽

Cited By ~ 4

Author(s):

Je Ho Ryu ◽

Shinae Kim ◽

Hye Young Han ◽

Hyun Joo Son ◽

Hyun Jung Lee ◽

...

Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitors Based on a Thieno[2,3-d]pyrimidin-4(3H)-one Core

Journal of Medicinal Chemistry ◽

10.1021/jm900928k ◽

2009 ◽

Vol 52 (21) ◽

pp. 6660-6671 ◽

Cited By ~ 29

Author(s):

Annamaria Lilienkampf ◽

Sampo Karkola ◽

Sari Alho-Richmond ◽

Pasi Koskimies ◽

Nina Johansson ◽

...

Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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