Heterocycles 27. Microwave Assisted Synthesis and Antitumour Activity of Novel Phenothiazinyl-Thiazolyl-Hydrazine Derivatives

2012 ◽  
Vol 345 (7) ◽  
pp. 574-583 ◽  
Author(s):  
Adriana Ignat ◽  
Tamas Lovasz ◽  
Mihai Vasilescu ◽  
Eva Fischer-Fodor ◽  
Corina Bianca Tatomir ◽  
...  
Keyword(s):  
Antitumour Activity ◽  
Microwave Assisted Synthesis ◽  
Hydrazine Derivatives ◽  
Microwave Assisted

scholarly journals Microwave Assisted Synthesis and Evaluation of Toxicity and Antioxidant Activity of Pyrazoline Derivatives

2019 ◽  
Vol 19 (3) ◽  
pp. 583
Author(s):  
Jasril Jasril ◽  
Hilwan Yuda Teruna ◽  
Aisyah Aisyah ◽  
Nurlaili Nurlaili ◽  
Rudi Hendra
Keyword(s):  
Antioxidant Activity ◽  
Second Step ◽  
Microwave Assisted Synthesis ◽  
Schmidt Reaction ◽  
Hydrazine Derivatives ◽  
Microwave Assisted ◽  
Intermolecular Cyclization ◽  
Ic50 Value ◽  
Toxicity Analysis ◽  
High Antioxidant Activity

Four pyrazoline analogues, 3-(4-methoxyphenyl)-5-naphthalene-1-yl-1-phenyl-4,5-dihydro-pyrazole (3), 3-(4-methoxyphenyl)-5-naphthalene-1-yl-4,5-dihydro-1H-pyrazole (4), 3-(2-methoxyphenyl)-5-naphthalene-1-yl-1-phenyl-4,5-dihydro-pyrazole (5) and 3-(2-methoxyphenyl)-5-naphthalene-1-yl-4,5-dihydro-1H-pyrazole (6) were synthesized via intermolecular cyclization between substituted chalcones and hydrazine derivatives. The compounds were synthesized in two steps. In the first step, the chalcones were synthesized by Claisen-Schmidt reaction. In the second step, they were cyclized with some hydrazine derivatives to form pyrazolines by using glacial acetic acid as a catalyst and assisted by microwave irradiation. The toxicity analysis showed that compound 1 and 2 were toxic with LC50 values of 11.47 and 0.97 μg/mL, respectively. Furthermore, only compound 6 showed high antioxidant activity by using DPPH with an IC50 value of 4.47 μg/mL.

ChemInform Abstract: Heterocycles. Part 27. Microwave-Assisted Synthesis and Antitumor Activity of Novel Phenothiazinyl-Thiazolyl-Hydrazine Derivatives.

ChemInform ◽  
2012 ◽  
Vol 43 (44) ◽  
pp. no-no
Author(s):  
Adriana Ignat ◽  
Tamas Lovasz ◽  
Mihai Vasilescu ◽  
Eva Fischer-Fodor ◽  
Corina Bianca Tatomir ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Microwave Assisted Synthesis ◽  
Hydrazine Derivatives ◽  
Microwave Assisted

Microwave Assisted Synthesis of Cationic Amino Sugar Surfactants

2020 ◽  
Vol 57 (3) ◽  
pp. 265-272
Author(s):  
Priya S. Singh ◽  
Aizaz Shaikh ◽  
Aditi Deshmukh ◽  
Amit P. Pratap
Keyword(s):  
Amino Sugar ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted

Pyrrole: Chemical Synthesis, Microwave Assisted Synthesis, Reactions and Applications: A Review

2013 ◽  
Vol 17 (20) ◽  
pp. 2279-2304 ◽  
Author(s):  
Shrinivas Joshi ◽  
Uttam More ◽  
Venkatrao Kulkarni ◽  
Tejraj Aminabhavi
Keyword(s):  
Chemical Synthesis ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Synthesis Reactions

Microwave assisted synthesis of novel Pyrazole derivatives and their biological evaluation as anti-bacterial agents

2020 ◽  
Vol 23 ◽  
Author(s):  
Hadis Khodadad ◽  
Farhad Hatamjafari ◽  
Khalil Pourshamsian ◽  
Babak Sadeghi
Keyword(s):  
Antibacterial Activity ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Antibacterial Activities ◽  
Structural Features ◽  
Biological Evaluation ◽  
Aureus Strain ◽  
Microwave Assisted Synthesis ◽  
Pyrazole Derivatives ◽  
Microwave Assisted

Aim and Objective: Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic acid in ethanol. Materials and Methods: The structural features of the synthesized compounds were characterized by melting point, FT-IR, 1H, 13C NMR and elemental analysis. Results: The antibacterial activities of the synthesized pyrazoles was evaluated against three gram-positive bacteria such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium. Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of them demonstrated antibacterial activity against E. coli.

Microwave Assisted Synthesis: A New Technology in Drug Discovery

2009 ◽  
Vol 9 (3) ◽  
pp. 340-358 ◽  
Author(s):  
V. Santagada ◽  
F. Frecentese ◽  
E. Perissutti ◽  
F. Fiorino ◽  
B. Severino ◽  
...  
Keyword(s):  
Drug Discovery ◽  
New Technology ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted
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