Structure-Activity Relationships Study of Bastadin 6, an Anti-Angiogenic Brominated-Tyrosine Derived Metabolite from Marine Sponge

2008 ◽  
Vol 341 (9) ◽  
pp. 568-577 ◽  
Author(s):  
Naoyuki Kotoku ◽  
Atsushi Hiramatsu ◽  
Hiroaki Tsujita ◽  
Yoichi Hirakawa ◽  
Mami Sanagawa ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Isolation, Derivative Synthesis, and Structure–Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis

2018 ◽  
Vol 81 (1) ◽  
pp. 188-202 ◽  
Author(s):  
Lizbeth L. L. Parra ◽  
Ariane F. Bertonha ◽  
Ivan R. M. Severo ◽  
Anna C. C. Aguiar ◽  
Guilherme E. de Souza ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Antioxidant Activity of Zyzzyanones and Makaluvamines from the Marine Sponge Zyzzya fuliginosa

2013 ◽  
Vol 8 (11) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Natalia K. Utkina
Keyword(s):  
Antioxidant Activity ◽  
Linoleic Acid ◽  
Marine Sponge ◽  
Antioxidant Activities ◽  
Side Chain ◽  
Scavenging Activity ◽  
Structural Variations ◽  
Abts Assay ◽  
Structure Activity Relationships ◽  
Structure Activity

Antioxidant activities of zyzzyanones A-D (1–4) and makaluvamines C (8), E (5), G (6), H (9), and L (7) isolated from the marine sponge Zyzzya fuliginosa (Carter, 1879) were evaluated using 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) scavenging assay and AAPH (2,2′-azobis(2-amidinopropane) dihydrochloride) induced autoxidation of linoleic acid. Zyzzyanones A, B (1, 2; TE = 0.3), C, D (3, 4; TE = 0.24) and makaluvamines 5–7 (TE = 0.6) displayed moderate activities in the ABTS assay and in the autoxidation of linoleic acid (61–66 % inhibition at concentrations of 0.1 mM). Makaluvamines C (8) and H (9) were essentially inactive in the both assays. Structure-activity relationships showed that antioxidant activities of tested compounds depended on the presence of a phenolic function in molecules. Makaluvamines 5–7 possessing a p-hydroxystyryl moiety were more active than zyzzyanones 1–4 possessing a p-hydroxyphenyl fragment. The presence of a charged side chain in 1 and 2 slightly increases their ABTS scavenging activity in comparison with compounds 3 and 4. Structural variations in a pyrroloquinoline skeleton of 5–7 and in a dipyrroloquinone core of 1–4 have no effect on activities.

scholarly journals Synthesis, Inhibitory Effects on Nitric Oxide and Structure-Activity Relationships of a Glycosphingolipid from the Marine Sponge Aplysinella rhax and Its Analogues

Molecules ◽  
2011 ◽  
Vol 16 (1) ◽  
pp. 637-651 ◽  
Author(s):  
Yuzo Fujita ◽  
Naohiro Ohshima ◽  
Ai Hasegawa ◽  
Frank Schweizer ◽  
Tadahiro Takeda ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Marine Sponge ◽  
Inhibitory Effects ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
Q Do ◽  
H Doan Thi Mai ◽  
T Gaslonde ◽  
B Pfeiffer ◽  
S Léonce ◽  
...  
Keyword(s):  
Pyran Ring ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure activity-relationships of P-Glycoprotein modulation using a small library of macrocyclic lathyrane diterpenes

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Reis ◽  
RJ Ferreira ◽  
MMM Santos ◽  
DJVA dos Santos ◽  
J Molnár ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
P Glycoprotein
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