Synthesis andIn Vitro Antibacterial Evaluation of Novel Imidazo[2′, 1′:5, 1]-1, 2, 4-triazolo[4, 3-c]-quinazoline Derivatives of 5-Thioxo-1, 2, 4-triazole, 4-Oxothiazolidine, and their Open-chain Counterparts

2003 ◽  
Vol 336 (12) ◽  
pp. 560-566 ◽  
Author(s):  
Magda N. Nasr ◽  
Magdy M. Gineinah ◽  
Eman R. El-Bendary
Keyword(s):  
Open Chain ◽  
Quinazoline Derivatives ◽  
Derivatives Of ◽  
Antibacterial Evaluation

Bacterial cell leakage potential of newly synthesized quinazoline derivatives of 1,5‐benzodiazepines analogue

2020 ◽  
Vol 57 (4) ◽  
pp. 1545-1558
Author(s):  
Apoorva Misra ◽  
Jaya Dwivedi ◽  
Shruti Shukla ◽  
Dharma Kishore ◽  
Swapnil Sharma
Keyword(s):  
Bacterial Cell ◽  
Quinazoline Derivatives ◽  
Derivatives Of ◽  
Cell Leakage

Quinazolinone Derivatives of Biological Interest V. Novel 4(3H)-Quinazolinones with Sedative-Hypnotic, Anticonvulsant and Antiinflammatory Activities

1993 ◽  
Vol 58 (8) ◽  
pp. 1963-1968 ◽  
Author(s):  
Abdel-Alim M. Abdel-Alim ◽  
Abdel-Nasser A. El-Shorbagi ◽  
Mahmoud A. El-Gendy ◽  
Hosny A. H. El-Shareif
Keyword(s):  
Present Communication ◽  
Biological Interest ◽  
Quinazoline Derivatives ◽  
Quinazolinone Derivatives ◽  
Derivatives Of

2-Methyl-4(3H)-quinazolines carrying alkyl, cycloalkyl, aralkyl or aryl substituents at N-3 of the quinazoline ring exhibit analgetic, antipyretic and antiinflammatory activities comparable to those of aspirin and phenylbutazone. In our previous work, various 4(3H)-quinazoline derivatives were prepared. The present communication is a continuation of our effort in this field.

Preparation and Disulfide Interchange Reactions of Unsymmetrical Open-chain Derivatives of Cystine

1959 ◽  
Vol 81 (7) ◽  
pp. 1729-1734 ◽  
Author(s):  
Leonidas Zervas ◽  
Leo Benoiton ◽  
Ellinor Weiss ◽  
Milton Winitz ◽  
Jesse P. Greenstein
Keyword(s):  
Open Chain ◽  
Derivatives Of ◽  
Interchange Reactions

Synthesis and antibacterial evaluation of novel Schiff's base derivatives of nitroimidazole nuclei as potent E. coli FabH inhibitors

RSC Advances ◽  
2014 ◽  
Vol 4 (97) ◽  
pp. 54217-54225 ◽  
Author(s):  
Xin Zhang ◽  
Chetan B. Sangani ◽  
Li-Xin Jia ◽  
Pi-Xian Gong ◽  
Fang Wang ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Schiff’S Base ◽  
E Coli ◽  
Derivatives Of ◽  
Antibacterial Evaluation ◽  
Potent Inhibitory Activity

Series of novel Schiff's base derivatives have been synthesized. Compound 10q showed the most potent inhibitory activity (IC50 = 2.6883 μM).

CERTAIN REACTIONS OF GAMMA KETONIC ACIDS

1934 ◽  
Vol 11 (3) ◽  
pp. 382-394 ◽  
Author(s):  
C. F. H. Allen ◽  
J. B. Normington ◽  
C. V. Wilson
Keyword(s):  
Levulinic Acid ◽  
Grignard Reagent ◽  
Acetyl Chloride ◽  
Methyl Esters ◽  
Open Chain ◽  
Unsaturated Lactones ◽  
Acrylic Acids ◽  
Derivatives Of

A considerable number of highly substituted acrylic acids or their lactols have been synthesized, and the Grignard reagent used to differentiate between the two possible structures. Acetyl chloride was found to be a satisfactory confirmatory agent, giving chlorides with the lactols, but not reacting with the open-chain acids. From the available evidence it is concluded that the differences may be attributed to cis-trans isomerism.Two other series of ketonic acids were investigated with both reagents; the Grignard reagent indicated mostly open-chain structures. The use of acetyl chloride led to a variety of products; by varying the procedure, dimers of undetermined structure, unsaturated lactones, enolic acetates, and methyl esters were obtained.Cyclohexanone gave cyclohexenyl acetate with acetyl chloride.The mechanism of the reactions is discussed, as well as the evidence for the possible structures of derivatives of levulinic acid. A mechanism is suggested to account for the formation of enolic esters and unsaturated lactones of enolized ketonic acids.

ChemInform Abstract: Synthesis and Antimicrobial Evaluation of Indole Containing Derivatives of 1,3,4-Thiadiazole, 1,2,4-Triazole and Their Open-Chain Counterparts.

ChemInform ◽  
2010 ◽  
Vol 28 (29) ◽  
pp. no-no ◽  
Author(s):  
A. TSOTINIS ◽  
A. VARVARESOU ◽  
T. CALOGEROPOULOU ◽  
T. SIATRA-PAPASTAIKOUDI ◽  
A. TILIGADA
Keyword(s):  
Open Chain ◽  
Antimicrobial Evaluation ◽  
Derivatives Of
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