scholarly journals Craniofacial growth in growth hormone-deficient rats

2004 ◽  
Vol 278A (2) ◽  
pp. 561-570 ◽  
Author(s):  
James R. Vandeberg ◽  
Peter H. Buschang ◽  
Robert J. Hinton
Keyword(s):  
Growth Hormone ◽  
Craniofacial Growth

Growth Hormone and Craniofacial Changes: Preliminary Data From Studies in Turner's Syndrome

PEDIATRICS ◽  
1999 ◽  
Vol 104 (Supplement_5) ◽  
pp. 1021-1024
Author(s):  
Kirt E. Simmons
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Dental Development ◽  
Turner's Syndrome ◽  
Craniofacial Growth ◽  
Insulin Like Growth Factor ◽  
Turner’S Syndrome ◽  
Mandibular Growth ◽  
Factor I ◽  
Control Subjects

Normal craniofacial and dental growth and development is dependent on growth hormone (GH) and insulin-like growth factor I (IGF-I). Deficiencies of either during childhood cause diminished growth of the maxilla and (to a greater degree) the mandible. Dental development/eruption also is compromised. Conversely, excessive GH/insulin-like growth factor I causes overgrowth, with the mandible again more affected than the maxilla. Replacement therapy in deficiency conditions generally normalizes craniofacial growth. Systemic GH also has been used in other disorders for which overt deficiency of GH has not been demonstrated. One such condition, Turner's syndrome, is now widely treated with GH. Although systemic GH in Turner's syndrome has been shown to positively affect stature, the effects on craniofacial growth and dental development/eruption are largely unknown. To explore these issues, standardized lateral radiographs of seven untreated patients with Turner's syndrome were analyzed and revealed hypoplasias of the cranial base, maxilla, and mandible. Dental development/eruption of patients with Turner's syndrome was found to be significantly advanced (by 0.63 years), relative to control subjects, in a separate study. Annual radiocephalometric measurements of 19 patients with Turner's syndrome treated with GH were compared with nonaffected control subjects over 1 year of treatment. Compared with age-matched historic control subjects, all maxillary—and most mandibular—growth measures were within 2 standard deviations of control. However, in our patients with Turner's syndrome, we found two measures of mandibular growth that deviated by more than 3 standard deviations from control. These data, although preliminary and only encompassing a short period, indicate that mandibular growth may be more affected than is maxillary growth by GH treatment and should be monitored over long-term-therapy.

scholarly journals Timing effects of growth hormone supplementation on rat craniofacial growth

2008 ◽  
Vol 30 (2) ◽  
pp. 153-162 ◽  
Author(s):  
G. C. Bills ◽  
P. H. Buschang ◽  
R. Ceen ◽  
R. J. Hinton
Keyword(s):  
Growth Hormone ◽  
Craniofacial Growth ◽  
Timing Effects

scholarly journals Effects of Growth Hormone on Craniofacial Growth

2006 ◽  
Vol 76 (6) ◽  
pp. 970-977 ◽  
Author(s):  
Minayo Funatsu ◽  
Koshi Sato ◽  
Hideo Mitani
Keyword(s):  
Growth Hormone ◽  
Therapy Group ◽  
Untreated Group ◽  
Term Therapy ◽  
Craniofacial Growth ◽  
Gh Therapy ◽  
Facial Height ◽  
Long Term Therapy ◽  
Ramus Height

Abstract Objective: This study determined the effects of growth hormone (GH) therapy on craniofacial growth in idiopathic growth hormone deficiency (GHD). Materials and Methods: Fifty-seven patients (33 boys and 24 girls; age range 4.5 to 16.7 years) with GHD were investigated and categorized into three groups according to the duration of GH therapy: the untreated group, the short-term therapy group, and the long-term therapy group. Their lateral cephalometric radiographs were studied, and craniofacial measurements were assessed by age and sex by using matched standard deviation scores. Results: In the untreated group, the anterior cranial base, total facial height, maxillary length, mandibular total length, mandibular body length, and ramus height were smaller than the standard values. In comparison with the untreated group, the long-term therapy group had a significantly larger upper facial height (P < .05), maxillary length (P < .01), and ramus height (P < .01) measurements. Conclusions: Children who received long-term GH replacement therapy showed increased growth of the craniofacial skeleton, especially the maxilla and ramus. These findings suggest that GH accelerates craniofacial development, which improves occlusion and the facial profile.

Effect of growth hormone treatment on craniofacial growth in Turner's syndrome

1993 ◽  
Vol 82 (4) ◽  
pp. 364-368 ◽  
Author(s):  
C Rongen-Westerlaken ◽  
E vd Born ◽  
B Prahl-Andersen ◽  
A v Teunenbroek ◽  
P Manesse ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Turner's Syndrome ◽  
Craniofacial Growth ◽  
Turner’S Syndrome

scholarly journals Craniofacial Morphology in Children with Growth Hormone Deficiency and Turner Syndrome

Diagnostics ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 88
Author(s):  
Dorota Wójcik ◽  
Iwona Beń-Skowronek
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Turner Syndrome ◽  
Orthodontic Treatment ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Craniofacial Morphology ◽  
Hormone Deficiency ◽  
Craniofacial Growth ◽  
Craniofacial Features

The review aims to collect and demonstrate recent knowledge about craniofacial morphology in growth hormone (GH)-deficient children and children with Turner syndrome. The review describes also the effects of growth hormone treatment on craniofacial morphology of children with growth hormone deficiency and Turner syndrome. Regardless of the disorder it accompanies, short stature is associated with similar craniofacial features characteristic of all short-statured children. Characteristic craniofacial features involve lesser dimensions of the cranial base and mandibular length, proportionately smaller posterior than anterior facial height, retrognathic face, and posterior rotation of the mandible. We also analyze orthodontic treatment in children affected by disorders associated with GH deficiency or provided with growth hormone treatment in the aspect of craniofacial growth. Recent publications show also the connection between growth hormone receptor polymorphism and craniofacial growth. Specialists and orthodontists treating short-statured children must be aware of the results of studies on craniofacial morphology and educate themselves on the topic of craniofacial growth in children with short stature. Moreover, knowledge of the influence of GH therapy on growth of craniofacial structures is necessary to decide the proper timing and planning of orthodontic treatment.

Craniofacial growth in growth hormone-deficient rats after growth hormone supplementation

2006 ◽  
Vol 130 (1) ◽  
pp. 69-82 ◽  
Author(s):  
Douglas A. Singleton ◽  
Peter H. Buschang ◽  
Rolf G. Behrents ◽  
Robert J. Hinton
Keyword(s):  
Growth Hormone ◽  
Craniofacial Growth
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