scholarly journals Combined detection of urinary biomarkers noninvasively predicts extent of renal injury in patients with early diabetic kidney disease with kidney qi deficiency syndrome: A retrospective investigation

2021 ◽  
Author(s):  
Wei Wu ◽  
Xian‐Jie Meng ◽  
Bing‐Ying Wan ◽  
Qi‐Jun Fang ◽  
Ying‐Lu Liu ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Renal Injury ◽  
Diabetic Kidney Disease ◽  
Deficiency Syndrome ◽  
Urinary Biomarkers ◽  
Diabetic Kidney ◽  
Combined Detection ◽  
Retrospective Investigation

scholarly journals Evaluation of Urinary Biomarkers for Coronary Artery Disease, Diabetes, and Diabetic Kidney Disease

2009 ◽  
Vol 11 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Janet K. Snell-Bergeon ◽  
David M. Maahs ◽  
Lorraine G. Ogden ◽  
Gregory L. Kinney ◽  
John E. Hokanson ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Urinary Biomarkers ◽  
Diabetic Kidney ◽  
Artery Disease

scholarly journals Urinary Periostin as an Early Predictor of Renal Injury in Diabetic Kidney Disease: A Tertiary Centre Experience

2019 ◽  
Vol 9 (3) ◽  
pp. 100-104
Author(s):  
Munna Lal Patel ◽  
Rekha Sachan ◽  
Durgesh Pushkar ◽  
Shyam Chand Chaudhary ◽  
Kamlesh Kumar Gupta
Keyword(s):  
Kidney Disease ◽  
Renal Injury ◽  
Diabetic Kidney Disease ◽  
Diabetic Kidney ◽  
Tertiary Centre ◽  
Early Predictor

Targeted deletion of NADPH-Oxidase Nox4 from proximal tubules is dispensable for diabetic kidney disease development

2020 ◽  
Author(s):  
Vicki Thallas-Bonke ◽  
Sih Min Tan ◽  
Runa S Lindblom ◽  
Matthew Snelson ◽  
Cesare Granata ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Nadph Oxidase ◽  
Renal Injury ◽  
Renal Fibrosis ◽  
Diabetic Kidney Disease ◽  
Proximal Tubules ◽  
Disease Development ◽  
Diabetic Kidney ◽  
Genetic Ablation ◽  
Proximal Tubular

Abstract Background The NADPH oxidase isoform, Nox4, mediates reactive oxygen species (ROS) production and renal fibrosis in diabetic kidney disease at the level of the podocyte. However, the mitochondrial localization of Nox4 and its role as a mitochondrial bioenergetic sensor has recently been reported. Whether Nox4 drives pathology in diabetic kidney disease within the proximal tubular compartment, which is densely packed with mitochondria, is not yet known. Methods We generated a proximal tubular specific Nox4 knockout mouse model by breeding Nox4flox/flox mice with mice expressing Cre recombinase under the control of the Sglt2 promoter. Subsets of Nox4ptKO mice and their Nox4flox/flox littermates were injected with streptozotocin (STZ) to induce diabetes. Mice were followed for 20 weeks and renal injury was assessed. Results Genetic ablation of proximal tubular Nox4 (Nox4ptKO) resulted in no change in renal function and histology. Nox4ptKO mice and Nox4flox/flox littermates injected with STZ exhibited the hallmarks of diabetic kidney disease including hyperfiltration, albuminuria, renal fibrosis and glomerulosclerosis. Surprisingly, diabetes-induced renal injury was not improved in Nox4ptKOSTZ mice compared to Nox4flox/flox STZ mice. Although diabetes conferred ROS overproduction and increased mitochondrial oxygen consumption rate, proximal tubular deletion of Nox4 did not normalize oxidative stress or mitochondrial bioenergetics. Conclusion Taken together, these results demonstrate that genetic deletion of Nox4 from the proximal tubules does not influence diabetic kidney disease development, indicating that Nox4 localization within this highly energetic compartment is dispensable for chronic kidney disease pathogenesis in the setting of diabetes.

Novel Urinary Biomarkers in Early Diabetic Kidney Disease

2014 ◽  
Vol 14 (8) ◽  
Author(s):  
Atsuko Kamijo-Ikemori ◽  
Takeshi Sugaya ◽  
Kenjiro Kimura
Keyword(s):  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Urinary Biomarkers ◽  
Diabetic Kidney

scholarly journals Evaluation of urinary biomarkers for prediction of diabetic kidney disease: a propensity score matching analysis

2019 ◽  
Vol 10 ◽  
pp. 204201881989111
Author(s):  
Yongzhang Qin ◽  
Shuang Zhang ◽  
Xiaofang Shen ◽  
Shunming Zhang ◽  
Jingyu Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Kidney Disease ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Diabetic Kidney Disease ◽  
Urinary Biomarkers ◽  
Retinol Binding Protein ◽  
Cross Sectional ◽  
Diabetic Kidney ◽  
Increased Risk

Background: The aim of this study was to evaluate the diagnostic value of six urinary biomarkers for prediction of diabetic kidney disease (DKD). Methods: The cross-sectional study recruited 1053 hospitalized patients with type 2 diabetes mellitus (T2DM), who were categorized into the diabetes mellitus (DM) with normoalbuminuria (NA) group ( n = 753) and DKD group ( n = 300) according to 24-h urinary albumin excretion rate (24-h UAE). Data on the levels of six studied urinary biomarkers [transferrin (TF), immunoglobulin G (IgG), retinol-binding protein (RBP), β-galactosidase (GAL), N-acetyl-beta-glucosaminidase (NAG), and β2-microglobulin (β2MG)] were obtained. The propensity score matching (PSM) method was applied to eliminate the influences of confounding variables. Results: Patients with DKD had higher levels of all six urinary biomarkers. All indicators demonstrated significantly increased risk of DKD, except for GAL and β2MG. Single RBP yielded the greatest area under the curve (AUC) value of 0.920 compared with the other five markers, followed by TF (0.867) and IgG (0.867). However, GAL, NAG, and β2MG were shown to have a weak prognostic ability. The diagnostic values of the different combinations were not superior to the single RBP. Conclusions: RBP, TF, and IgG could be used as reliable or good predictors of DKD. The combined use of these biomarkers did not improve DKD detection.

scholarly journals Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility

Diabetes ◽  
2019 ◽  
Vol 69 (1) ◽  
pp. 83-98 ◽  
Author(s):  
Sih Min Tan ◽  
Mark Ziemann ◽  
Vicki Thallas-Bonke ◽  
Matthew Snelson ◽  
Vinod Kumar ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Renal Injury ◽  
Diabetic Kidney Disease ◽  
Diabetic Kidney ◽  
Complement C5a
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