Nuclear organization of catecholaminergic neurons in the brains of a lar gibbon and a chimpanzee

Nuclear organization and morphology of catecholaminergic neurons and certain pallial terminal networks in the brain of the Nile crocodile, Crocodylus niloticus

Journal of Chemical Neuroanatomy ◽

10.1016/j.jchemneu.2020.101851 ◽

2020 ◽

Vol 109 ◽

pp. 101851

Author(s):

Brendon K. Billings ◽

Adhil Bhagwandin ◽

Nina Patzke ◽

Ayanda Ngwenya ◽

Noemi Rook ◽

...

Keyword(s):

Nuclear Organization ◽

Catecholaminergic Neurons ◽

Nile Crocodile ◽

The Brain

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Author response for "Amphibian thalamic nuclear organization during larval development and in the adult frog Xenopus laevis : genoarchitecture and hodological analysis"

10.1002/cne.24899/v2/response1 ◽

2020 ◽

Author(s):

Ruth Morona ◽

Sandra Bandín ◽

Jesús M. López ◽

Nerea Moreno ◽

Agustín González

Keyword(s):

Xenopus Laevis ◽

Larval Development ◽

Nuclear Organization ◽

Author Response ◽

Adult Frog

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Quantitative Model-Based Image Analysis of NuMa Distribution Links Nuclear Organization with Cell Phenotype

Microscopy and Microanalysis ◽

10.1017/s1431927600028968 ◽

2001 ◽

Vol 7 (S2) ◽

pp. 578-579

Author(s):

David W. Knowles ◽

Sophie A. Lelièvre ◽

Carlos Ortiz de Solόrzano ◽

Stephen J. Lockett ◽

Mina J. Bissell ◽

...

Keyword(s):

Image Analysis ◽

Mammary Epithelial Cells ◽

Nuclear Organization ◽

Critical Role ◽

Quantitative Model ◽

Mammary Epithelial ◽

Cell Phenotype ◽

Proliferating Cells ◽

Mitotic Apparatus ◽

Model Based

The extracellular matrix (ECM) plays a critical role in directing cell behaviour and morphogenesis by regulating gene expression and nuclear organization. Using non-malignant (S1) human mammary epithelial cells (HMECs), it was previously shown that ECM-induced morphogenesis is accompanied by the redistribution of nuclear mitotic apparatus (NuMA) protein from a diffuse pattern in proliferating cells, to a multi-focal pattern as HMECs growth arrested and completed morphogenesis . A process taking 10 to 14 days.To further investigate the link between NuMA distribution and the growth stage of HMECs, we have investigated the distribution of NuMA in non-malignant S1 cells and their malignant, T4, counter-part using a novel model-based image analysis technique. This technique, based on a multi-scale Gaussian blur analysis (Figure 1), quantifies the size of punctate features in an image. Cells were cultured in the presence and absence of a reconstituted basement membrane (rBM) and imaged in 3D using confocal microscopy, for fluorescently labeled monoclonal antibodies to NuMA (fαNuMA) and fluorescently labeled total DNA.

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