Reactivity of human labial glands in response to cevimeline treatment

2021 ◽  
Author(s):  
Francesco Loy ◽  
Michela Isola ◽  
Carla Masala ◽  
Raffaella Isola
Keyword(s):  
Labial Glands

Labial Glands

2008 ◽  
pp. 2097-2097
Author(s):  
Laura T. Miller ◽  
Lionel Stange ◽  
Charles MacVean ◽  
Jorge R. Rey ◽  
J. H. Frank ◽  
...  
Keyword(s):  
Labial Glands

scholarly journals Histological and certain histochemical observations on the labial salivary glands of the buffalo , bubalus bubalis.

2010 ◽  
Vol 9 (1) ◽  
pp. 17
Author(s):  
A. I. Jabbar
Keyword(s):  
Salivary Glands ◽  
Bubalus Bubalis ◽  
Myoepithelial Cells ◽  
Ductal System ◽  
Labial Glands

Histological, morphometric and histochemical investigations were carried out on the labial salivary glands of the buffalo. Both the upper and lower labial glands of the buffalo are branched tubuloacinar type and composed of serous acini surrounded by myoepithelial cells. Histochemically it showed seromucous character, they secrete neutral mucopolysaccharides, mucopolysaccharides acid, and few sulfated mucopolysaccharides. The labial salivary glands of buffalo posses ductal system of both the intralobular ductules and interlobular ducts.

In vivo imaging of human labial glands using advanced optical coherence tomography

2009 ◽  
Vol 108 (3) ◽  
pp. 425-429 ◽  
Author(s):  
Nobuyoshi Ozawa ◽  
Yasunori Sumi ◽  
Kazuo Shimozato ◽  
Changho Chong ◽  
Tohru Kurabayashi
Keyword(s):  
Optical Coherence Tomography ◽  
In Vivo Imaging ◽  
Optical Coherence ◽  
Labial Glands

Immunocytochemical localisation of neuropeptide-containing nerve fibres in human labial glands

1999 ◽  
Vol 44 ◽  
pp. S33-S37 ◽  
Author(s):  
Erzsébet Fehér ◽  
T. Zelles ◽  
G. Nagy
Keyword(s):  
Nerve Fibres ◽  
Labial Glands

Observations on the Incidence of Trypanosomes in Glossina palpalis (R.-D.) in Sierra Leone

1954 ◽  
Vol 45 (4) ◽  
pp. 797-801 ◽  
Author(s):  
F. A. Squire
Keyword(s):  
Sierra Leone ◽  
Inverse Correlation ◽  
Heavy Rain ◽  
Trypanosoma Vivax ◽  
Significant Inverse Correlation ◽  
Virtual Absence ◽  
Active Life ◽  
Glossina Palpalis ◽  
Labial Glands ◽  
Made In

Observations were made in Sierra Leone from September 1949 to November 1951 on the incidence of trypanosomes in Glossina palpalis (R.-D.), in continuation of those previously reported that began in September 1948. Flies were dissected; trypanosomes found to be restricted to the proboscis were classed as Trypanosoma vivax and those found also or only in the mid-gut as T. congolense. None of the flies had infected labial glands. The whole data are presented for the sexes separately by months.The existence of a marked seasonal variation in the incidence of T. vivax in G. palpalis is confirmed. The highest rates of infection occured in the months of heavy rain, and there was a significant inverse correlation between the monthly means of infection rate and of hours of sunshine. The cause is unknown, but possible explanations are discussed.The older the fly, as judged by its appearance, the greater the rate of infection by both species of trypanosme; the virtual absence of infection in the youngest group of flies does not support the theory that they can only be infected when very young.In the case of T. vivax, but not in that of T. congolense, females flies were more heavily infected than males. This may be due to larger food intake by the females, or to males, because of their more active life, appearing to be older than they are.

scholarly journals CMTM6: Increased Circulating Level and Up-regulated Expression in Labial Salivary Glands in Patients with Primary Sjogren’s Syndrome

2021 ◽  
Author(s):  
Sirui Qian ◽  
Jingyi Xu ◽  
Shan Zhao ◽  
Pingting Yang ◽  
Chunshu Yang
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Programmed Death ◽  
Labial Glands ◽  
Sjögren‘S Syndrome

Abstract Chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing family member 6 (CMTM6), which is a key regulator of programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) signaling in patients with primary Sjögren’s syndrome (pSS). In the present paper, we analysed the serum levels of CMTM6, PD-1 and PD-L1 in 50 patients with pSS, 42 patients with non-pSS (simply dry mouth and/or eyes symptoms) and 50 healthy controls (HC). The expression of CMTM6, PD-1 and PD-L1 in labial glands of the same 50 pSS patients and 42 non-pSS patients were assessed by immunohistochemistry (IHC). The clinical significance of CMTM6, PD-1 and PD-L1 were analyzed. We found that levels of CMTM6, PD-L1 as well as PD-1 in sera were all increased significantly in patients with pSS compared with non-pSS controls and HC. Serum CMTM6 level showed significantly correlation with PD-L1, PD-1, as well as clinical laboratory indicators and disease activity of pSS patients. CMTM6, PD-1 and PD-L1 expression in labial glands was also higher significantly in pSS patients than non-pSS controls. pSS patients with higher CM grade or ESSDAI score have higher CMTM6, PD-L1 and PD-1expression in labial glands. These results suggests that CMTM6 may affect peripheral tolerance and lymphocytes activation by PD-1/PD-L1 pathway in sera and target tissue in pSS.

scholarly journals The Transcriptome of Paired Major and Minor Salivary Gland Tissue in Patients With Primary Sjögren’s Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Gwenny M. Verstappen ◽  
Lu Gao ◽  
Sarah Pringle ◽  
Erlin A. Haacke ◽  
Bert van der Vegt ◽  
...  
Keyword(s):  
Salivary Gland ◽  
B Cells ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Salivary Gland Tissue ◽  
Gland Tissue ◽  
Labial Glands

BackgroundWhile all salivary glands (SGs) can be involved in primary Sjögren’s syndrome (pSS), their respective role in pathogenesis remains unclear. Our objective was to assess immunopathway activation in paired parotid and labial gland tissue from biopsy-positive and biopsy-negative pSS and non-SS sicca patients.MethodsParaffin-embedded, paired parotid and labial salivary gland tissue and peripheral blood mononuclear cells were obtained from 39 pSS and 20 non-SS sicca patients. RNA was extracted, complementary DNA libraries were prepared and sequenced. For analysis of differentially expressed genes (DEGs), patients were subdivided based on fulfillment of ACR-EULAR criteria and histopathology.ResultsWith principal component analysis, only biopsy-positive pSS could be separated from non-SS sicca patients based on SG gene expression. When comparing the transcriptome of biopsy-positive pSS and biopsy-negative non-SS sicca patients, 1235 and 624 DEGs (FDR<0.05, log2FC<-1 or >1) were identified for parotid and labial glands, respectively. The number of DEGs between biopsy-negative pSS and non-SS sicca patients was scarce. Overall, transcript expression levels correlated strongly between parotid and labial glands (R2 = 0.86, p-value<0.0001). Gene signatures present in both glands of biopsy-positive pSS patients included IFN-α signaling, IL-12/IL-18 signaling, CD3/CD28 T-cell activation, CD40 signaling in B-cells, DN2 B-cells, and FcRL4+ B-cells. Signature scores varied considerably amongst pSS patients.ConclusionTranscriptomes of paired major and minor SGs in pSS were overall comparable, although significant inter-individual heterogeneity in immunopathway activation existed. The SG transcriptome of biopsy-negative pSS was indistinguishable from non-SS sicca patients. Different patterns of SG immunopathway activation in pSS argue for personalized treatment approaches.

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