Orientation of the round window membrane: A normative study of inner ear anatomical orientation using 2D projections of 3D volumes

2019 ◽  
Vol 303 (11) ◽  
pp. 2847-2856
Author(s):  
Isaac B. Rutel ◽  
Julie Stoner ◽  
Pravina Kota ◽  
Kenneth Dormer ◽  
Anthony Alleman
Keyword(s):  
Inner Ear ◽  
Round Window ◽  
Round Window Membrane ◽  
Normative Study

scholarly journals Cutaneous and Labyrinthine Tolerance of Bioactive Glass S53P4 in Mastoid and Epitympanic Obliteration Surgery: Prospective Clinical Study

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Daniele Bernardeschi ◽  
Yann Nguyen ◽  
Francesca Yoshie Russo ◽  
Isabelle Mosnier ◽  
Evelyne Ferrary ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Inner Ear ◽  
Round Window ◽  
Bone Conduction ◽  
Hearing Threshold ◽  
Round Window Membrane ◽  
Prospective Clinical Study ◽  
Local Skin ◽  
Local Skin Reaction ◽  
Bone Conduction Hearing

Objective. To evaluate the cutaneous and the inner ear tolerance of bioactive glass S53P4 when used in the mastoid and epitympanic obliteration for chronic otitis surgery.Material and Methods. Forty-one cases have been included in this prospective study. Cutaneous tolerance was clinically evaluated 1 week, 1 month, and 3 months after surgery with a physical examination of the retroauricular and external auditory canal (EAC) skin and the presence of otalgia; the inner ear tolerance was assessed by bone-conduction hearing threshold 1 day after surgery and by the presence of vertigo or imbalance.Results. All surgeries but 1 were uneventful: all patients maintained the preoperative bone-conduction hearing threshold except for one case in which the round window membrane was opened during the dissection of the cholesteatoma in the hypotympanum and this led to a dead ear. No dizziness or vertigo was reported. Three months after surgery, healing was achieved in all cases with a healthy painless skin. No cases of revision surgery for removal of the granules occurred in this study.Conclusion. The bioactive glass S53P4 is a well-tolerated biomaterial for primary or revision chronic otitis surgery, as shown by the local skin reaction which lasted less than 3 months and by the absence of labyrinthine complications.

Inner Ear Pathology and Otitis Media

1980 ◽  
Vol 89 (3_suppl) ◽  
pp. 249-253 ◽  
Author(s):  
Michael M. Paparella ◽  
Marcos V. Goycoolea ◽  
William L. Meyerhoff
Keyword(s):  
Inner Ear ◽  
Otitis Media ◽  
Round Window ◽  
Round Window Membrane

Insidious inner ear complications of otitis media have been and are being studied in our laboratory. The purpose of this paper is to review these studies, coordinate, capsulize and highlight the results with emphasis on the transport role of the round window membrane.

Eradicating Otomycosis with Terbinafine Solution: Basic and Clinical Investigation

2019 ◽  
Vol 24 (4) ◽  
pp. 183-190
Author(s):  
Ting-Hua Yang ◽  
Yi-Ho Young
Keyword(s):  
Clinical Practice ◽  
Inner Ear ◽  
Morphological Study ◽  
Antifungal Agents ◽  
Clinical Investigation ◽  
Round Window ◽  
Round Window Membrane ◽  
Potential Candidate ◽  
Potential Treatment ◽  
Total Dosage

Background: Otomycosis still remains intractable in clinical practice, likely because topical antifungal agents lack efficacy or are potentially toxic to the inner ear end organs. Objectives: The aim of this study was to investigate whether terbinafine solution is a potential candidate for treating intractable otomycosis in humans. In addition, the toxic effect on the inner ear was also assessed by animal models treated with terbinafine. Methods: Guinea pigs were instilled with 0.1 mL terbinafine (10 and 25 mg/mL) in the left round window membrane. At 2 weeks after treatment, all animals underwent an inner ear test battery and were then sacrificed for morphological study. Clinically, 20 patients with otomycosis were treated with terbinafine solution at a dosage of 0.4 mg. Results: All terbinafine-treated animals showed intact inner ear function when total dosage of terbinafine was <2.5 mg, which was further confirmed by morphological study. Subsidence of otomycosis was achieved in all 20 patients 1 week after treatment with terbinafine (0.4 mg) without untoward effect. No evidence of recurrence was noted 1 year after treatment. Conclusion: The paucity of inner ear toxicity of terbinafine even at a dosage of 2.5 mg was identified in guinea pig models morphologically and physiologically. Topical application of terbinafine solution at a dosage of 0.4 mg may be a potential treatment for otomycosis in humans.

Intratympanic Steroid Treatment of Inner Ear Disease and Tinnitus (Preliminary Report)

1996 ◽  
Vol 75 (8) ◽  
pp. 468-488 ◽  
Author(s):  
Herbert Silverstein ◽  
Daniel Choo ◽  
Seth I. Rosenberg ◽  
Jeffery Kuhn ◽  
Michael Seidman ◽  
...  
Keyword(s):  
Inner Ear ◽  
Round Window ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Round Window Membrane ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Inner Ear Disease ◽  
Ménière's Disease

Intratympanic instillation of Depo-Medrol® (80 mg/cc), dexamethasone ophthalmic solution (1 mg/cc), or dexamethasone intravenous (4 mg/cc) solution produces improvement of cochlear function in certain patients with Meniere's disease, autoimmune inner ear disease and sudden sensorineural deafness. Tinnitus improved in 47%, most often in patients with Meniere's disease (9 of 15; 60%). The SRT improvement of greater than 10 dB or SD greater than 15% was documented in 41% (average improvement in SRT: 15 dB; SD: 24%). Patients with tinnitus and bilateral sensorineural hearing loss (i.e., presbycusis) did not benefit from the treatment. Prior to treatment with intratympanic medication, laser-assisted tympanostomy with middle ear exploration, using otoendoscopy to determine the status of the round window niche and remove mucosal folds, helps in making the round window membrane accessible to local application of drops. Placing Gelfoam into the round window niche under direct vision, and using a Venturi Bobbin tube in the tympanic membrane, appears to be a satisfactory method for delivering medication to the inner ear fluids. The medication can be injected by the physician through the tube into the middle ear, or the patient can perform self-treatment at home, placing medication in the external auditory canal. A double-blind, cross-over study in patients with Meniere's disease is now in progress with Institutional Review Board (IRB) approval, which will be reported at a later date. This preliminary study has shown that intratympanic steroids may affect the symptoms of hearing loss and tinnitus in patients with various inner ear problems. Patients with Meniere's disease appear to respond in the highest percentage of cases. Hopefully, additional research will suggest the appropriate drugs which can be used to treat inner ear disease. Direct application of the drug to the round window membrane may increase the concentration in the inner ear fluids, thus avoiding the systemic effects.

Inner ear biocompatibility of lipid nanocapsules after round window membrane application

2011 ◽  
Vol 404 (1-2) ◽  
pp. 211-219 ◽  
Author(s):  
Ya Zhang ◽  
Weikai Zhang ◽  
Marian Löbler ◽  
Klaus-Peter Schmitz ◽  
Patrick Saulnier ◽  
...  
Keyword(s):  
Inner Ear ◽  
Round Window ◽  
Round Window Membrane ◽  
Lipid Nanocapsules

scholarly journals Effect of oxygen-flooding to the round window membrane on the inner ear function of the anoxic cochlea.

1986 ◽  
Vol 79 (7) ◽  
pp. 1143-1147
Author(s):  
Toshimitsu KOBAYASHI ◽  
Takuji OKITSU ◽  
Katsuhisa IKEDA ◽  
Jun KUSAKARI
Keyword(s):  
Inner Ear ◽  
Round Window ◽  
Round Window Membrane ◽  
Effect Of Oxygen

Spontaneous Remission in Experimental Autoimmune Labyrinthitis

1992 ◽  
Vol 101 (12) ◽  
pp. 1007-1014 ◽  
Author(s):  
Shigeharu Yamanobe ◽  
Jeffrey P. Harris
Keyword(s):  
Inner Ear ◽  
Time Course ◽  
Round Window ◽  
Spontaneous Remission ◽  
Intradermal Injection ◽  
Round Window Membrane ◽  
Cellular Infiltration ◽  
Auditory Brain Stem Response ◽  
Hearing Thresholds ◽  
Experimental Autoimmune

We investigated the time course of hearing impairment and cellular infiltration into the inner ear after systemic sensitization of guinea Pigs with a single intradermal injection of bovine inner ear antigen (IEAg) in complete Freund's adjuvant (CFA). Lymphocytes and polymorphonucleocytes appeared mainly in the scala tympani on days 7 to 14, and in addition there was thickening and cellular infiltration of the round window membrane at day 14. These cellular infiltrations resolved after day 28. The auditory brain stem response thresholds from IEAg-sensitized animals were significantly elevated after day 7. Some sensitized animals (n = 5) had spontaneous remissions after day 28; however, the hearing thresholds did not completely recover. These results demonstrate that experimental autoimmune labyrinthitis can be induced by a single inoculation of IEAg-CFA and that remission, as evidenced by clearing of the cochlear cellular infiltration and improved hearing thresholds, can occur spontaneously.

scholarly journals Efficiency of a Dexamethasone Nanosuspension as an Intratympanic Injection for Acute Hearing Loss

2021 ◽  
Author(s):  
So-Young Jung ◽  
Zion Kang ◽  
Soonmin Kwon ◽  
Juhye Lee ◽  
Subin Kim ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Round Window ◽  
Round Window Membrane ◽  
In Vivo Test ◽  
Drug Concentrations ◽  
Intratympanic Injection ◽  
Acute Hearing Loss

Abstract Background: Dexamethasone sodium phosphate (Dex-SP) is the most commonly used drug for intratympanic injection in acute hearing loss, but its penetration efficiency into the inner ear is very low. To address this problem, we evaluated the possibility of dexamethasone nanosuspensions as intratympanic injection because the lipophilicity of drugs can affect their permeation of the round window membrane, an important pathway from the middle ear to the cochlea.Results: Three types of dexamethasone nanosuspensions were prepared; the dexamethasone nanocrystals in the three nanosuspensions were between approximately 250 and 350 nm in size. In order to compare the efficiency of Dex-SP and a dexamethasone nanosuspension in delivering dexamethasone to the inner ear, the concentrations of dexamethasone in perilymph and cochlear tissues were compared by liquid chromatography–mass spectrometry. The dexamethasone nanosuspensions showed significantly higher drug concentrations in perilymph and cochlear tissue than Dex-SP at 6 h; interestingly, animals treated with a nanosuspension showed a 26-fold higher dexamethasone concentration in the cochlear tissue than the Dex-SP group. In addition, the dexamethasone nanosuspension achieved better glucocorticoid receptor phosphorylation than Dex-SP both in vitro and in vivo, and in the ototoxic animal model, it showed a significantly better hearing protective effect than Dex-SP against ototoxic drugs. In safety evaluation, the nanosuspension showed no toxicity at concentrations up to 20 mg/mL in an in vivo test.Conclusions: A nanosuspension of dexamethasone was able to deliver dexamethasone to the cochlea very safely and efficiently and showed potential as a formula for intratympanic injection. In addition, it can be applied in studies on the delivery of various hydrophobic antioxidants to treat acute hearing loss.

Temporal Bone Pathology in Scuba Diving Deaths

1993 ◽  
Vol 109 (3) ◽  
pp. 514-521 ◽  
Author(s):  
Patrick J. Antonelli ◽  
G. Joseph Parell ◽  
Gary D. Becker ◽  
Michael M. Paparella
Keyword(s):  
Inner Ear ◽  
Temporal Bone ◽  
Round Window ◽  
Scuba Diving ◽  
Round Window Membrane ◽  
Bone Pathology ◽  
Rapid Ascent ◽  
Temporal Bones ◽  
Inner Ear Damage ◽  
Air Cells

Scuba diving has long been associated with otologic injuries; however, little is known about temporal bone pathology in diving-related deaths. We examined 18 temporal bones from 11 divers who died, primarily from complications of rapid ascent. Bleeding into the middle ear and mastoid air cells was nearly universal. Inner ear damage included hemorrhage around Reissner's membrane and the round window membrane and rupture of the utricle and saccule. Most of the observed inner ear damage was not surgically treatable. (OTOLARYNGOL HEAD NECK SURG 1993;109:514-21.)

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