scholarly journals Neuropeptide AF Induces Piecemeal Degranulation in Murine Mucosal Mast Cells: A New Mediator in Neuro-Immune Communication in the Intestinal Lamina Propria?

2018 ◽  
Vol 301 (6) ◽  
pp. 1103-1114 ◽  
Author(s):  
Nada Abdellah ◽  
Samuel van Remoortel ◽  
Omnia Mohey-Elsaeed ◽  
Mohamed-Nabil Mustafa ◽  
Yasser A. Ahmed ◽  
...  
Keyword(s):  
Mast Cells ◽  
Lamina Propria ◽  
Intestinal Lamina Propria ◽  
Mucosal Mast Cells

QUANTITATIVE EFFECT OF SOME STEROID HORMONES ON THE MUCOSAL MAST CELLS AND TISSUE EOSINOPHILS IN THE RAT STOMACH WALL

1961 ◽  
Vol 37 (1) ◽  
pp. 153-160 ◽  
Author(s):  
Toimi Räsänen
Keyword(s):  
Mast Cells ◽  
Gastric Mucosa ◽  
Steroid Hormones ◽  
Lamina Propria ◽  
Stomach Wall ◽  
Rat Stomach ◽  
Intestinal Canal ◽  
Tissue Eosinophilia ◽  
Mucosal Mast Cells ◽  
Higher Doses

ABSTRACT Prednisolone (11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione) injected into rats at 6 hour intervals for 48 hours causes degranulation of the mast cells of the gastric mucosa to an extent dependent on the dose. Tissue eosinophilia in the gastric lamina propria decreased more slowly with the smallest dose, but clearly with the higher doses. Deoxycorticosterone (21-hydroxy-pregn-4-ene-3,20-dione) in doses of varying size produced no definite degranulation of the mast cells of the gastric mucosa, nor any changes in the tissue eosinophilia of the lamina propria. It is suggested that glucocorticoids conjugate in the lamina propria of the gastro-intestinal canal with the polysaccharides of the mast granules, and that the tissue eosinophils eliminate the histamine and serotonin liberated.

The protease phenotype and crystalline nature of the granules of intraepithelial mast cells in Trichinella spiralis-infected mice

1995 ◽  
Vol 53 ◽  
pp. 818-819
Author(s):  
D.S. Friend ◽  
N. Ghildyal ◽  
M.F. Gurish ◽  
K.F. Austen ◽  
R.L. Stevens
Keyword(s):  
Small Intestine ◽  
Mast Cells ◽  
Epithelial Cells ◽  
Lamina Propria ◽  
Trichinella Spiralis ◽  
Intestinal Epithelial ◽  
Carboxypeptidase A ◽  
C3h Mice ◽  
Granule Morphology ◽  
Crystalline Nature

Trichinella spiralis induces a profound mastocytosis and eosinophilia in the small intestine of the infected mouse. Mouse mast cells (MC) store in their granules various combinations of at least five chymotryptic chymases [designated mouse MC protease (mMCP) 1 to 5], two tryptic proteases designated mMCP-6 and mMCP-7 and an exopeptidase, carboxypeptidase A (mMC-CPA). Using antipeptide, protease -specific antibodies to these MC granule proteases, immunohistochemistry was done to determine the distribution, number and protease phenotype of the MCs in the small intestine and spleen 10 to >60 days after Trichinella infection of BALB/c and C3H mice. TEM was performed to evaluate the granule morphology of the MCs between intestinal epithelial cells and in the lamina propria (mucosal MCs) and in the submucosa, muscle and serosa of the intestine (submucosal MCs).As noted in the table below, the number of submucosal MCs remained constant throughout the study. In contrast, on day 14, the number of MCs in the mucosa increased ~25 fold. Increased numbers of MCs were observed between epithelial cells in the mucosal crypts, in the lamina propria and to a lesser extent, between epithelial cells of the intestinal villi.

Author response for "The role of galanin in the differentiation of mucosal mast cells in mice"

2019 ◽  
Author(s):  
Tomoko Yamaguchi ◽  
Yumi Ikeda ◽  
Katsuhisa Tashiro ◽  
Yasuyuki Ohkawa ◽  
Kenji Kawabata
Keyword(s):  
Mast Cells ◽  
Author Response ◽  
Mucosal Mast Cells

scholarly journals Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1586
Author(s):  
Tomoe Yashiro ◽  
Hanako Ogata ◽  
Syed Faisal Zaidi ◽  
Jaemin Lee ◽  
Shusaku Hayashi ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mast Cells ◽  
Imaging System ◽  
Receptor Gene ◽  
Nerve Fibers ◽  
Enteric Neurons ◽  
Food Allergies ◽  
Adenosine A3 Receptor ◽  
Myenteric Neurons ◽  
Mucosal Mast Cells

Recently, the involvement of the nervous system in the pathology of allergic diseases has attracted increasing interest. However, the precise pathophysiological role of enteric neurons in food allergies has not been elucidated. We report the presence of functional high-affinity IgE receptors (FcεRIs) in enteric neurons. FcεRI immunoreactivities were observed in approximately 70% of cholinergic myenteric neurons from choline acetyltransferase-eGFP mice. Furthermore, stimulation by IgE-antigen elevated intracellular Ca2+ concentration in isolated myenteric neurons from normal mice, suggesting that FcεRIs are capable of activating myenteric neurons. Additionally, the morphological investigation revealed that the majority of mucosal mast cells were in close proximity to enteric nerve fibers in the colonic mucosa of food allergy mice. Next, using a newly developed coculture system of isolated myenteric neurons and mucosal-type bone-marrow-derived mast cells (mBMMCs) with a calcium imaging system, we demonstrated that the stimulation of isolated myenteric neurons by veratridine caused the activation of mBMMCs, which was suppressed by the adenosine A3 receptor antagonist MRE 3008F20. Moreover, the expression of the adenosine A3 receptor gene was detected in mBMMCs. Therefore, in conclusion, it is suggested that, through interaction with mucosal mast cells, IgE-antigen-activated myenteric neurons play a pathological role in further exacerbating the pathology of food allergy.

scholarly journals Are Gastrointestinal Mucosal Mast Cells Increased in Patients With Systemic Mastocytosis?

2004 ◽  
Vol 122 (4) ◽  
pp. 560-565 ◽  
Author(s):  
Sabine I. Siegert ◽  
Joachim Diebold ◽  
Dagmar Ludolph-Hauser ◽  
Udo Löhrs
Keyword(s):  
Mast Cells ◽  
Systemic Mastocytosis ◽  
Mucosal Mast Cells
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