scholarly journals AComparative Immunohistochemical Study of Anal Canal Epithelium in Humans and Swine, Focusing on the Anal Transitional Zone Epithelium and the Anal Glands

2017 ◽  
Vol 301 (5) ◽  
pp. 796-805 ◽  
Author(s):  
Futoshi Muranaka ◽  
Tomoyuki Nakajima ◽  
Mai Iwaya ◽  
Keiko Ishii ◽  
Kayoko Higuchi ◽  
...  
Keyword(s):  
Anal Canal ◽  
Immunohistochemical Study ◽  
Transitional Zone ◽  
Anal Glands ◽  
Anal Transitional Zone

scholarly journals Pouch Surgery — The Importance of the Transitional Zone

1990 ◽  
Vol 4 (7) ◽  
pp. 428-431 ◽  
Author(s):  
IC Lavery ◽  
WB Tuckson ◽  
VW Fazio ◽  
JR Oakley ◽  
JM Church ◽  
...  
Keyword(s):  
Anal Canal ◽  
Internal Anal Sphincter ◽  
Transitional Zone ◽  
Stool Frequency ◽  
Factors Affecting ◽  
Anal Transitional Zone ◽  
Significant Difference ◽  
Resting Pressure ◽  
Pouch Surgery ◽  
Maximum Resting Pressure

Patients with preservation of the transitional zone of the anal canal have less leakage and less need to wear pads than patients who have had mucosectomy. There is a significant difference in mean maximum resting pressure between patients that have had anal transitional zone preservation and mucosectomy. With preservation of the anal transitional zone, a mean maximum resting pressure of 57.6±3.8 mmHg was obtained compared with 47.3±4 mmHg in the mucosectomy group. Preservation of the resting pressure is dependent on preservation of internal anal sphincter integrity. The integrity of the sphincter is injured during mucosectomy due to anal dilation. Other factors affecting continence and stool frequency, such as diet, antidiarrheal medications, stool consistency and compliance, when examined were found to be unrelated factors.

How consistent is the anal transitional zone in the double-stapled ileoanal reservoir?

2003 ◽  
Vol 18 (2) ◽  
pp. 116-120 ◽  
Author(s):  
Hong-Jo Choi ◽  
Naoto Saigusa ◽  
Jeong-Seok Choi ◽  
Eung-Jin Shin ◽  
Eric G. Weiss ◽  
...  
Keyword(s):  
Transitional Zone ◽  
Ileoanal Reservoir ◽  
Anal Transitional Zone

Incidence, Risk Factors and Outcomes of Cancer of the Anal Transitional Zone in Patients with Ulcerative Colitis

2020 ◽  
Vol 14 (11) ◽  
pp. 1565-1571
Author(s):  
Yuki Horio ◽  
Motoi Uchino ◽  
Toshihiro Bando ◽  
Hirofumi Sasaki ◽  
Yoshiko Goto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ulcerative Colitis ◽  
Survival Rate ◽  
De Novo ◽  
Transitional Zone ◽  
Anal Transitional Zone ◽  
Small Series ◽  
Operative Specimen ◽  
Incidence Risk ◽  
Pouch Cancer

Abstract Background and Aims Performing a mucosectomy with a hand-sewn ileal pouch-anal anastomosis [IPAA] for ulcerative colitis [UC] theoretically reduces the risk of carcinoma arising from the anal transitional zone [ATZ]. Although current guidelines suggest a stapled anastomosis due to the low incidence of cancer after pouch surgery in UC patients, only a few small series have addressed the oncological advantage of mucosectomy. Therefore, we aimed to investigate the incidence of ATZ/pouch cancer. Methods A total of 1970 UC patients who underwent surgery between April 1987 and December 2018 were included. We retrospectively analysed the incidences of primary ATZ cancer in the original operative specimen and de novo ATZ/pouch cancer after surgery. Possible risk factors for primary ATZ cancer and the pouch survival rate were assessed. Results Fourteen [6.4%] primary ATZ cancers developed in 220 UC-colorectal cancer [CRC] cases. Multiple (odds ratio [OR] = 8.79, 95% confidence interval [CI] 2.77–27.83, p < 0.01) and rectal [OR = 6.48, 95% CI 1.41–29.7, p = 0.01] cancers were identified as independent risk factors for primary ATZ cancer. Four of 1970 [0.2%] patients developed de novo ATZ/pouch cancer and dysplasia. The 10-year estimated cumulative pouch survival rate was not significantly different between stapled IPAA and hand-sewn IPAA cases [95.9% and 97.3%, p = 0.25]. Conclusion The risk of de novo ATZ/pouch cancer and dysplasia was rare. The decision to perform a hand-sewn or a stapled IAA should be made on a case-by-case basis. However, the relatively high incidence of primary ATZ cancer in UC patients with CRC suggests that mucosectomy should be recommended for this patient group.

p53, MIB-1, BAX and BCL-2 expression in anal transitional zone (ATZ) dysplasia following ileo-pouch anal anastomosis (IPAA) for inflammatory bowel disease (IBD)

2001 ◽  
Vol 120 (5) ◽  
pp. A268
Author(s):  
Adrian H. Ormsby ◽  
Robert E. Petras ◽  
Terry L. Gramlich ◽  
Victor W. Fazio ◽  
Feza H. Remzi ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Transitional Zone ◽  
Anal Transitional Zone ◽  
Anal Anastomosis ◽  
Inflammatory Bowel ◽  
Mib 1

Prolapse-induced inflammatory polyps of the colorectum and anal transitional zone

1993 ◽  
Vol 23 (1) ◽  
pp. 63-67 ◽  
Author(s):  
R. CHETTY ◽  
P.S. BHATHAL ◽  
J.L. SLAVIN
Keyword(s):  
Transitional Zone ◽  
Anal Transitional Zone
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