The Incidence of Invasion and Metastasis of Nasopharyngeal Carcinoma at Different Anatomic Sites in the Skull Base

2012 ◽  
Vol 295 (8) ◽  
pp. 1252-1259 ◽  
Author(s):  
Jun Han ◽  
Qiuhang Zhang ◽  
Feng Kong ◽  
Yongan Gao
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Skull Base ◽  
Invasion And Metastasis

scholarly journals Bone Subtraction Iodine Imaging Using Area Detector CT for Evaluation of Skull Base Invasion by Nasopharyngeal Carcinoma

2018 ◽  
Vol 40 (1) ◽  
pp. 135-141 ◽  
Author(s):  
T. Hiyama ◽  
H. Kuno ◽  
K. Sekiya ◽  
S. Tsushima ◽  
O. Sakai ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Skull Base ◽  
Area Detector

scholarly journals miR-206 regulates a metabolic switch in nasopharyngeal carcinoma by suppressing HK2 expression

2020 ◽  
Author(s):  
Chunying Luo ◽  
Min Liu ◽  
Jianwei Zhang ◽  
Guoqiang Su ◽  
Zhonghua Wei
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Warburg Effect ◽  
Carcinoma Cells ◽  
Luciferase Reporter ◽  
Metabolic Shift ◽  
Invasion And Metastasis ◽  
Metabolic Switch ◽  
And Function ◽  
The Relationship

Abstract Background: Many studies have shown that microRNAs play key functions in nasopharyngeal carcinoma proliferation, invasion and metastasis. However, whether the dysregulated level of miRNAs contributes to the metabolic shift in nasopharyngeal carcinoma is not completely understood.Objectives: This study was conducted to explore the expression and function of miR-206 in nasopharyngeal carcinoma.Methods: miR-206 expression level was examined by real-time PCR. miR-206 inhibitor, mimics, and scrambled control were transiently transfected into nasopharyngeal carcinoma cells and their effects on colony formation, glucose uptake, and lactate secretion were observed in vitro. Moreover, the relationship between the levels of miR-206 and HK2 was examined by luciferase reporter and assay western blot.Results: In our study, we reported downregulation of miR-206 expression leads to metabolic change in nasopharyngeal carcinoma cells. miR-206 controls this function by enhancing HK2 expression. The enhancement of aerobic metabolism activity induced by miR-206 leads to the rapid proliferation of nasopharyngeal carcinoma cells.Conclusions: Our data demonstrated that miR-206 was involved in the regulation of Warburg effect in nasopharyngeal carcinoma by suppressing HK2 expression.

Study the effect of CTSD interaction proteins in invasion and metastasis of nasopharyngeal carcinoma

2017 ◽  
Vol 6 (6) ◽  
pp. 1236-1247
Author(s):  
Weiguo Huang ◽  
Yafei Wang ◽  
Guqing Zeng ◽  
Yufang Yin ◽  
Chenjie Ouyang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Invasion And Metastasis
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