scholarly journals Epithelial cell dynamics in rabbit cecum and proximal colon P1

2001 ◽  
Vol 264 (4) ◽  
pp. 427-437 ◽  
Author(s):  
T. Dawn Grant ◽  
Robert D. Specian
2013 ◽  
Vol 242 (9) ◽  
pp. C1-C1 ◽  
Author(s):  
Jeff C. Hsu ◽  
Hyun Koo ◽  
Jill S. Harunaga ◽  
Kazue Matsumoto ◽  
Andrew D. Doyle ◽  
...  

2021 ◽  
Author(s):  
Satoshi Kozuki ◽  
Satoko Sakurai ◽  
Atsushi Suzuki ◽  
Takuya Yamamoto ◽  
Fumiko Toyoshima

1989 ◽  
Vol 257 (1) ◽  
pp. E27-E34 ◽  
Author(s):  
D. J. Pillion ◽  
J. F. Haskell ◽  
J. A. Atchison ◽  
V. Ganapathy ◽  
F. H. Leibach

Rabbit proximal colon epithelial cell apical membranes, which are known to contain receptors for insulin, were isolated by a Ca2+-precipitation technique. Binding assays with 125I-insulin-like growth factor I (IGF-I) revealed the presence of specific high-affinity binding sites, with 50% inhibition of binding observed at a concentration of 13.7 ng/ml IGF-I. In contrast, 50% inhibition of 125I-IGF-I binding was observed at an insulin concentration of 1.37 micrograms/ml, suggesting that 125I-IGF-I was not binding to insulin receptors present in this tissue. Cross-linking studies revealed an 125I-IGF-I binding subunit of relative molecular weight (Mr) of 130,000 under reducing conditions on docecyl sulfate-polyacrylamide gel electrophoresis that was similar to the IGF-I binding subunit in human placental membranes (Mr 140,000). Binding and cross-linking studies with 125I-insulin-like growth factor II (IGF-II), however, failed to reveal a specific receptor for this peptide in colon epithelial cell membranes. These results establish the coexistence of receptors for IGF-I and insulin, but not IGF-II, on rabbit proximal colon epithelial cell apical membranes and demonstrate that colon epithelial cells are capable of selective synthesis of various peptide hormone receptors.


Oncogene ◽  
2017 ◽  
Vol 37 (5) ◽  
pp. 578-588 ◽  
Author(s):  
Y Idoux-Gillet ◽  
M Nassour ◽  
E Lakis ◽  
F Bonini ◽  
C Theillet ◽  
...  

2013 ◽  
Vol 242 (9) ◽  
pp. 1066-1077 ◽  
Author(s):  
Jeff C. Hsu ◽  
Hyun Koo ◽  
Jill S. Harunaga ◽  
Kazue Matsumoto ◽  
Andrew D. Doyle ◽  
...  

1973 ◽  
Vol 10 (4) ◽  
pp. 330-341 ◽  
Author(s):  
D. C. Thake ◽  
H. W. Moon ◽  
G. Lambert

Tritiated thymidine was given to pigs that had been exposed to transmissible gastroenteritis virus, and specimens of small intestine for autoradiographic studies were subsequently obtained. There was villous atrophy in the jejunum and ileum, but not duodenum, of the infected pigs by 48 h after exposure. Rates of migration of epithelial cells were substantially greater, and DNA synthesis occurred at a greater distance from the base of the crypts in the jejunum and ileum of infected than control pigs. Total numbers of labeled cells were two to three times greater in the jejunum and ileum of infected than control pigs. These findings indicate that viral destruction of villous epithelial cells results in an increased rate of cell migration in the jejunum and ileum, which is responsible for the appearance of incompletely differentiated cells on the villi of pigs with transmissible gastroenteritis.


Development ◽  
2017 ◽  
Vol 144 (13) ◽  
pp. 2517-2528 ◽  
Author(s):  
D'Juan T. Farmer ◽  
Sara Nathan ◽  
Jennifer K. Finley ◽  
Kevin Shengyang Yu ◽  
Elaine Emmerson ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document