Association of the cardiac neural crest with development of the coronary arteries in the chick embryo

1994 ◽  
Vol 239 (3) ◽  
pp. 315-331 ◽  
Author(s):  
Karen L. Waldo ◽  
Donna H. Kumiski ◽  
Margaret L. Kirby
Keyword(s):  
Chick Embryo ◽  
Neural Crest ◽  
Coronary Arteries ◽  
Cardiac Neural Crest

scholarly journals Effects of the size of lesions of the cardiac neural crest at various embryonic ages on incidence and type of cardiac defects.

Circulation ◽  
1986 ◽  
Vol 73 (2) ◽  
pp. 360-364 ◽  
Author(s):  
W T Besson ◽  
M L Kirby ◽  
L H Van Mierop ◽  
J R Teabeaut
Keyword(s):  
Neural Crest ◽  
Cardiac Defects ◽  
Cardiac Neural Crest

Non-malignant migration of B16 mouse melanoma cells in the neural crest and invasive growth in the eye cup of the chick embryo

2007 ◽  
Vol 17 (1) ◽  
pp. 17-30 ◽  
Author(s):  
Matthias Oppitz ◽  
Christian Busch ◽  
Gernot Schriek ◽  
Marco Metzger ◽  
Lothar Just ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Neural Crest ◽  
Melanoma Cells ◽  
Invasive Growth ◽  
Mouse Melanoma ◽  
B16 Mouse Melanoma

Overexpression of Snail family members highlights their ability to promote chick neural crest formation

Development ◽  
2002 ◽  
Vol 129 (7) ◽  
pp. 1583-1593 ◽  
Author(s):  
Marta G. del Barrio ◽  
M. Angela Nieto
Keyword(s):  
Chick Embryo ◽  
Neural Crest ◽  
Neural Tube ◽  
Family Members ◽  
Ectopic Expression ◽  
Endogenous Gene ◽  
The Family ◽  
Snail Family ◽  
Migratory Cells ◽  
Snail Gene

The Snail gene family of transcription factors plays crucial roles in different morphogenetic processes during the development of vertebrate and invertebrate embryos. In previous studies of function interference for one of the family members, Slug, we showed its involvement and neural crest formation in the chick embryo. Now we have carried out a series of gain-of-function experiments in which we show that Slug overexpression in the neural tube of the chick embryo induces an increase in neural crest production. The analysis of electroporated embryos shows that Slug can induce the expression of rhoB and an increase in the number of HNK-1-positive migratory cells, indicating that it lies upstream of them in the genetic cascade of neural crest development. The increase in neural crest production after Slug overexpression was confined to the cranial region, indicating that the mechanisms of crest induction somehow differ between head and trunk. The expression of the two vertebrate family members, Slug and Snail, is peculiar with respect to the neural crest. Slug is not expressed in the premigratory crest in the mouse, whereas it is expressed in this cell population in the chick and the opposite is true for Snail(Sefton, M., Sánchez, S. and Nieto M. A. (1998) Development125, 3111-3121). This raises the question of whether they can be functionally equivalent. To test this hypothesis both intra- and interspecies, we have performed a series of ectopic expression experiments by electroporating chick and mouse Snail in the chick embryo hindbrain. We observe that both genes elicit the same responses in the neural tube. Our results indicate that they can be functionally equivalent, although the embryos show a higher response to the endogenous gene, chick Slug.

scholarly journals Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion

2018 ◽  
Vol 247 (12) ◽  
pp. 1286-1296 ◽  
Author(s):  
Kimberly E. Inman ◽  
Carlo Donato Caiaffa ◽  
Kristin R. Melton ◽  
Lisa L. Sandell ◽  
Annita Achilleos ◽  
...  
Keyword(s):  
Cell Migration ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Outflow Tract ◽  
Cardiac Neural Crest ◽  
Neural Crest Cell Migration ◽  
Crest Cell

scholarly journals Twist1 performs distinct spatio‐temporal functions in developing cardiac neural crest cells

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Joshua Wayne Vincentz ◽  
Ralston Barnes ◽  
Beth Firulli ◽  
Douglas Spicer ◽  
Anthony Firulli
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Cardiac Neural Crest ◽  
Spatio Temporal

scholarly journals Epigenetic Regulation of Cardiac Neural Crest Cells

2021 ◽  
Vol 9 ◽  
Author(s):  
Shun Yan ◽  
Jin Lu ◽  
Kai Jiao
Keyword(s):  
Neural Crest ◽  
Epigenetic Regulation ◽  
Heart Development ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Heart Defects ◽  
Neural Crest Cells ◽  
Abnormal Development ◽  
Cardiac Neural Crest ◽  
Epigenetic Regulators

The cardiac neural crest cells (cNCCs) is a transient, migratory cell population that contribute to the formation of major arteries and the septa and valves of the heart. Abnormal development of cNCCs leads to a spectrum of congenital heart defects that mainly affect the outflow region of the hearts. Signaling molecules and transcription factors are the best studied regulatory events controlling cNCC development. In recent years, however, accumulated evidence supports that epigenetic regulation also plays an important role in cNCC development. Here, we summarize the functions of epigenetic regulators during cNCC development as well as cNCC related cardiovascular defects. These factors include ATP-dependent chromatin remodeling factors, histone modifiers and DNA methylation modulators. In many cases, mutations in the genes encoding these factors are known to cause inborn heart diseases. A better understanding of epigenetic regulators, their activities and their roles during heart development will ultimately contribute to the development of new clinical applications for patients with congenital heart disease.

Sign in / Sign up

Export Citation Format

Share Document