Development of PGP 9.5- and calcitonin gene-related peptide-like immunoreactivity in organ cultured fetal rat lungs

1993 ◽  
Vol 236 (1) ◽  
pp. 213-225 ◽  
Author(s):  
Sergei P. Sorokin ◽  
Masahito Ebina ◽  
Richard F. Hoyt
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Pgp 9.5 ◽  
Related Peptide ◽  
Rat Lungs ◽  
Fetal Rat ◽  
Calcitonin Gene

Interaction of calcitonin gene-related peptide with the calcitonin receptor in fetal rat osteoclasts

1988 ◽  
Vol 117 (4_Suppl) ◽  
pp. S84-S85 ◽  
Author(s):  
K. FRANK ◽  
K. FIDORRA ◽  
F. RAUE ◽  
H.W. MINNE ◽  
R. ZIEGLER
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Calcitonin Receptor ◽  
Related Peptide ◽  
Fetal Rat ◽  
Calcitonin Gene

Calcitonin gene-related peptide modulates pulmonary vascular reactivity in isolated rat lungs

1994 ◽  
Vol 77 (1) ◽  
pp. 142-146 ◽  
Author(s):  
P. L. Janssen ◽  
A. Tucker
Keyword(s):  
Vascular Reactivity ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Acute Hypoxia ◽  
Calcitonin Gene Related Peptide ◽  
Ang Ii ◽  
Related Peptide ◽  
Pulmonary Vasoconstriction ◽  
Rat Lungs ◽  
Pressor Responses ◽  
Calcitonin Gene

The role of calcitonin gene-related peptide (CGRP) in modulating hypoxic pulmonary vasoconstriction was assessed. The effects of CGRP and its antagonist [CGRP-(8–37)] on responses to acute hypoxia (3% O2) and angiotensin II (ANG II; 0.4 microgram) were studied in isolated lungs of male Sprague-Dawley rats perfused with a salt solution. Rats with pulmonary hypertension, induced by simulated altitude exposure, were also used to determine the actions of CGRP in a remodeled pulmonary vascular bed. In normotensive (NT) and altitude-exposed (AE) lungs, CGRP injections (10 nM), given after stable pressor responses were attained, attenuated (P < 0.05) subsequent hypoxic pressor responses. Pretreatment with CGRP-(8–37) (10 nM) enhanced (P < or = 0.05) initial ANG II-induced pressor responses in both AE and NT lungs. CGRP-(8–37) pretreatment (10 nM) had little influence on the hypoxic pressor responses in either NT or AE lungs. Results indicate that CGRP modulates hypoxic pulmonary vasoconstriction and that CGRP-(8–37) enhances pressor responses to ANG II in NT and AE rat lungs.

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