Comparative ultrastructural morphometric analysis of atrial specific granules in the bat, mouse, and rat

1993 ◽  
Vol 235 (1) ◽  
pp. 87-94 ◽  
Author(s):  
C. N. B. Tagoe ◽  
A. S. Ayettey ◽  
R. D. Yates
Keyword(s):  
Morphometric Analysis ◽  
Specific Granules ◽  
Atrial Specific Granules

Atrial-specific granules in the hearts of normal and water-deprived rats

1988 ◽  
Vol 253 (3) ◽  
pp. 547-552 ◽  
Author(s):  
Hirotaka Toshimori ◽  
Kiyotaka Toshimori ◽  
Shigeru Matsukura ◽  
Chikayoshi Ōura ◽  
Hisayuki Matsuo
Keyword(s):  
Specific Granules ◽  
Atrial Specific Granules

Synthesis and renal activity of rat atrial granules depend on extracellular volume

1984 ◽  
Vol 247 (4) ◽  
pp. R750-R752
Author(s):  
U. Ackermann ◽  
T. G. Irizawa
Keyword(s):  
Atrial Natriuretic Factor ◽  
Extracellular Volume ◽  
Extracellular Fluid ◽  
Fluid Volume ◽  
Extracellular Fluid Volume ◽  
Deoxycorticosterone Acetate ◽  
Natriuretic Factor ◽  
Specific Granules ◽  
Atrial Specific Granules ◽  
Natriuretic Effect

Extracellular fluid volume (by 22Na) and extent of 4-h [3H]fucose incorporation into atrial-specific granules were measured in deoxycorticosterone acetate (DOCA)/salt-loaded or Na-deficient rats. The natriuretic potency of extracts from their atria was also measured in assay rats. DOCA/salt-treated animals had a significantly greater extracellular volume, a significantly greater degree of fucose uptake, and a significantly more potent diuretic and natriuretic effect than did Na-deficient rats. These observations, together with the known decrease in atrial granularity with DOCA treatment, suggest that a chronic increase in extracellular fluid volume is associated with increased synthesis and metabolism of atrial natriuretic factor. They also confirm the finding reported by others that granularity and natriuretic potency are not always directly related. It may be that visible granules represent a peptide storage form that requires further processing to become natriuretic.

Morphometry of Equine Neutrophils Isolated at Different Temperatures

1982 ◽  
Vol 19 (5) ◽  
pp. 534-543 ◽  
Author(s):  
T. A. Bertram ◽  
F. L. Coignoul
Keyword(s):  
Morphometric Analysis ◽  
Peripheral Blood ◽  
Cell Swelling ◽  
Human Neutrophils ◽  
Density Gradients ◽  
Specific Granules ◽  
Neutrophil Degranulation ◽  
Different Temperatures ◽  
Primary Granules ◽  
In Cells

Equine neutrophils were evaluated ultrastructurally and by morphometric analysis. Homogeneous populations of neutrophils were isolated from peripheral blood at 4° and 22°C by centrifugation on two sequential Ficoll-Hypaque density gradients. Isolation procedures at both temperatures resulted in neutrophil degranulation but not cell swelling. Degranulation was more extensive in cells isolated at 22°C. Isolation temperature affected the neutrophil content of secondary granules more than primary granules. A granule similar to immature specific granules of human neutrophils was observed. Granules with a flocculent matrix were more frequent in cells processed at 22°C. These granules were considered to be involved in the degranulation process.

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