Effects of daily administration of prostaglandin E2 and its withdrawal on the lumbar vertebral bodies in male rats

1992 ◽  
Vol 234 (2) ◽  
pp. 172-182 ◽  
Author(s):  
Hua Zhu Ke ◽  
Webster S. S. Jee
Keyword(s):  
Prostaglandin E2 ◽  
Daily Administration ◽  
Male Rats ◽  
Vertebral Bodies

scholarly journals Effects of long-term daily administration of prostaglandin-E2 on maintaining elevated proximal tibial metaphyseal cancellous bone mass in male rats

1992 ◽  
Vol 50 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Hua Zhu Ke ◽  
Webster S. S. Jee ◽  
Satoshi Mori ◽  
Xiao Jian Li ◽  
Donald B. Kimmel
Keyword(s):  
Bone Mass ◽  
Prostaglandin E2 ◽  
Cancellous Bone ◽  
Daily Administration ◽  
Male Rats

EFFECTS OF TESTOSTERONE AND NANDROLONE AND SOME OF THEIR ESTERS ON THE PSEUDOCHOLINESTERASE ACTIVITY IN THE LIVER AND SERUM AND ON THE SEMINAL VESICLE AND LEVATOR ANI MUSCLE OF THE RAT

1970 ◽  
Vol 64 (3) ◽  
pp. 531-540 ◽  
Author(s):  
R. S. Leeuwin ◽  
E. Th. Groenewoud
Keyword(s):  
Enzyme Activity ◽  
Seminal Vesicle ◽  
Testosterone Propionate ◽  
Levator Ani ◽  
Daily Administration ◽  
Male Rats ◽  
Levator Ani Muscle ◽  
Prolonged Administration ◽  
Potent Effect ◽  
T Testosterone

ABSTRACT Testosterone (T), testosterone-propionate (TP), testosterone-phenyl-propionate (TPP), nandrolone (N) (19-nor-testosterone) and nandrolone-phenyl-propionate (NPP) were compared for their effects on the pseudocholinesterase activities in the liver and serum of castrated male rats. In addition changes in the weight of the seminal vesicle and the levator ani muscle were studied. After daily administration of 1 mg of the hormones for ten days, T and TPP showed a more marked depression of the pseudocholinesterase activity and seminal vesicle than the corresponding nor-derivatives. TP and TPP have approximately similar effects, exceeding those of T. On the levator ani N and NPP were more effective than T and TPP. At identical total doses, administration of all hormones with intervals of more than one day, produced less depression of the pseudocholinesterase activity and less seminal vesicle growth than daily administration. The effects on the levator ani were less influenced by varying intervals. At an interval of four days TPP still had a potent effect on the enzyme activity and the seminal vesicle, whereas T was almost without effect. Prolonged administration showed that the effects on the enzyme activity and the seminal vesicle of N and NPP could not reach the maximum effects of T and TPP respectively.

EFFECT OF THE PITUITARY INHIBITOR I.C.I. 33,828 (METHALLIBURE) ON THE REPRODUCTIVE SYSTEM OF MALE RATS

1968 ◽  
Vol 40 (3) ◽  
pp. 275-284 ◽  
Author(s):  
B. N. HEMSWORTH ◽  
H. JACKSON ◽  
A. L. WALPOLE
Keyword(s):  
Germ Cells ◽  
Reproductive System ◽  
Seminiferous Epithelium ◽  
Pituitary Function ◽  
Daily Administration ◽  
Male Rats ◽  
Close Similarity ◽  
Lethal Mutations ◽  
Cessation Of Treatment

SUMMARY Impairment of pituitary function in male rats by I.C.I. 33,828 (1-α-methylallylthiocarbamoyl-2-methylthiocarbamoylhydrazine; methallibure) caused arrest of sperm iogenesis beyond step 8, without apparently interfering with the timing of the cycle of the seminiferous epithelium. In this respect there was a close similarity between the effect of the drug and that of hypophysectomy. Uninterrupted daily administration was required and after cessation of treatment, pituitary function was rapidly restored. The antifertility effect of the compound in male rats is due to reduced libido, arrest of spermiogenesis and possibly the induction of 'lethal mutations' in developing germ cells.

Cyclic and diurnal alterations in the response of luteinizing hormone and prolactin to prostaglandin E2 during the rat oestrous cycle

1984 ◽  
Vol 106 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Lise Wogensen ◽  
Jørgen Warberg
Keyword(s):  
Luteinizing Hormone ◽  
Prostaglandin E2 ◽  
Lateral Ventricle ◽  
Mature Female ◽  
Oestrous Cycle ◽  
Female Rats ◽  
Male Rats ◽  
Prostaglandin E ◽  
The Brain ◽  
Time Of Administration

Abstract. Two μg of prostaglandin E2 (PGE2) was infused into a lateral ventricle of the brain of female rats at 09.00 or 13.00 h on the different days of the oestrous cycle and the effect on luteinizing hormone (LH) and prolactin (Prl) release was determined. At 09.00 h PGE2 caused a pronounced release of LH in pro-oestrous, oestrous and metoestrous rats whereas the LH response in dioestrous rats was moderate. The secretion of Prl was only stimulated in rats from the pro-oestrous phase. When infused at 13.00 h PGE2 had a marked stimulatory effect on the release of LH in all groups of rats. The response was almost the same in oestrous, metoestrous and dioestrous rats but pro-oestrous rats a 2-fold higher LH response was observed. On each day of the oestrous cycle it was found that the LH-releasing activity of PGE2 was greater at 13.00 h than at 09.00 h. Thus, the overall greatest responsiveness of LH to PGE2 was noted at 13.00 h on pro-oestrus i.e. at a time which was prior to the onset of the spontaneous LH surge. At 13.00 h – as at 09.00 h – PGE2 was only capable of stimulating Prl release in pro-oestrous rats. Resembling the LH response it was found that PGE2-induced Prl release was greater at 13.00 h than at 09.00 h. In adult male rats the stimulatory effect of PGE2 on LH and Prl release was independent of the time of administration. It is concluded that the neuroendocrine elements of the hypothalamo-pituitary unit in mature female rats exhibit cyclic as well as diurnal alterations in the responsiveness to PGE2.

Anabolic effect of prostaglandin E2 on cortical bone of aged male rats comes mainly from modeling-dependent bone gain

Bone ◽  
1999 ◽  
Vol 25 (6) ◽  
pp. 697-702 ◽  
Author(s):  
W Yao ◽  
W.S.S Jee ◽  
H Zhou ◽  
J Lu ◽  
L Cui ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Cortical Bone ◽  
Male Rats ◽  
Anabolic Effect ◽  
Bone Gain

Central administration of prostaglandin E2 suppresses in vitro cellular immune responses

1995 ◽  
Vol 269 (1) ◽  
pp. R92-R97 ◽  
Author(s):  
S. Rassnick ◽  
D. Zhou ◽  
B. S. Rabin
Keyword(s):  
Immune System ◽  
Prostaglandin E2 ◽  
B Lymphocyte ◽  
Plasma Concentrations ◽  
Peripheral Blood Lymphocytes ◽  
Male Rats ◽  
System Function ◽  
Central Administration ◽  
Immune System Function

Research suggests that the regulation of the function of the immune system by the central nervous system (CNS) involves the integrative responses of multiple neural systems that affect neuroendocrine and sympathetic nervous systems. To determine whether prostaglandin E2 (PGE2) is involved in the modulatory mechanisms of immune system function, it was administered intracerebroventricularly (ICV) to conscious male rats. One hour later, spleen and peripheral blood lymphocytes were collected for culture with nonspecific mitogens. ICV administration of PGE2 decreased blood lymphocyte proliferative responses to the T-cell mitogens phytohemagglutinin and concanavalin A and decreased spleen lymphocyte proliferative responses to phytohemagglutinin and lipopolysaccharide (a B-lymphocyte mitogen). ICV administered PGE2 also stimulated the activity of the hypothalamic-pituitary-adrenal axis, as reflected by increased plasma concentrations of adrenocorticotropic hormone and corticosterone. Thus PGE2 may act in the CNS as a hormonal modulator of immune system function.

Long-term anabolic effects of prostaglandin-E2 on tibial diaphyseal bone in male rats

1991 ◽  
Vol 15 (1) ◽  
pp. 33-55 ◽  
Author(s):  
Webster S.S. Jee ◽  
Ke Hua Zhu ◽  
Li Xiao Jian
Keyword(s):  
Prostaglandin E2 ◽  
Male Rats ◽  
Diaphyseal Bone

scholarly journals STRUCTURAL AND FUNCTIONAL CHANGES IN BONE TISSUE OF THE SPINE AND EXTREMITIES IN OXYS RATS

2006 ◽  
pp. 088-094 ◽  
Author(s):  
Olga Viktorovna Falameeva ◽  
Mikhail Anatolyevich Sadovoy ◽  
Yulia Viktorovna Khrapova ◽  
Natalya Gorislavovna Kolosova
Keyword(s):  
Bone Tissue ◽  
Oxys Rats ◽  
Male Rats ◽  
Histomorphometric Analysis ◽  
Mineral Density ◽  
X Ray ◽  
Functional Changes ◽  
Tissue Changes ◽  
Bone Fragments ◽  
Vertebral Bodies

Objective. To study specific structural and functional changes in bone tissue in Oxys rats of different age. Material and Methods. Mineral density of bone tissue in Oxys and Wistar male rats at the age of 2–18 months was examined with x-ray bone densitometer LUNAR-Exert-XL (USA). Bone fragments of vertebral bodies and of forelegs and hind legs were studied by histomorphometric assay with software Motic Images Plus 2.0 ML (Micromed, Russia). Results. X-ray bone densitometry findings have shown that bone mineral density increase in Oxys rats does not attain the values shown by age-matched control rats, and progressively decreases after the age of 6 months. Data obtained by histomorphometric analysis of vertebral bodies and limbs have reliably demonstrated that there is a change in quantitative and qualitative bone tissue parameters of Oxys rats which is a characteristic of osteoporosis. Conclusion. Bone tissue changes in Oxys rats correspond to that observed in human osteoporosis, what allows to use rat as a model for the study of osteoporosis pathogenesis and for development of prophylaxis and treatment methods.

scholarly journals Comparable impediment of cognitive function in female and male rats subsequent to daily administration of haloperidol after traumatic brain injury

2017 ◽  
Vol 296 ◽  
pp. 62-68 ◽  
Author(s):  
Kristin E. Free ◽  
Anna M. Greene ◽  
Corina O. Bondi ◽  
Naima Lajud ◽  
Patricia B. de la Tremblaye ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Function ◽  
Daily Administration ◽  
Male Rats

scholarly journals EFFICACY AND MECHANISM OF TRADITIONAL CHINESE MEDICINE GEL IN SPORTS-RELATED SOFT TISSUE INJURY

2021 ◽  
Vol 27 (spe2) ◽  
pp. 54-57
Author(s):  
Li Chen ◽  
Meiling Miao
Keyword(s):  
Chinese Medicine ◽  
Soft Tissue ◽  
Traditional Chinese Medicine ◽  
Prostaglandin E2 ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Male Rats ◽  
Control Group ◽  
Common Disease ◽  
Therapeutic Effects

ABSTRACT Soft tissue injury is the most common disease in orthopedics, and it is also the most easily neglected disease in sports. Without timely and effective treatment, it is easy to develop into malignant strain and seriously affect life and sports. In view of this, the aim of this study is to analyze the effect and mechanism of traditional Chinese medicine gel in treating such injuries in the light of the characteristics of sports-related soft tissue injury. The right gastrocnemius muscle injury was simulated in 36 adult male rats. Chinese medicine gel and tincture were used to treat it. The contents of interleukin, alanine aminotransferase, blood urea nitrogen and prostaglandin E2 in the blood of rats under different courses of treatment were analyzed to explore recovery in four rats. The results showed that the levels of interleukin and prostaglandin E2 in the blood of rats treated with drugs were significantly lower than those in the control group (p<0.05), indicating that both drugs have obvious therapeutic effects on soft tissue injury. The content of interleukin in the blood of the Chinese medicine gel group was slightly lower than that of the tincture group, indicating that the Chinese medicine gel could affect the recovery of soft tissue injury by affecting leukocyte interleukin. This result is helpful in the treatment of soft tissue injury in sports and to further improve the therapeutic effect of traditional Chinese medicine gel.

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