In vivo morphometry and functional morphology of brown adipose tissue by magnetic resonance imaging

1991 ◽  
Vol 231 (3) ◽  
pp. 293-297 ◽  
Author(s):  
Andrea Sbarbati ◽  
Angela Maria Baldassarri ◽  
Carlo Zancanaro ◽  
Andrea Boicelli ◽  
Francesco Osculati
Keyword(s):  
Magnetic Resonance Imaging ◽  
Adipose Tissue ◽  
Magnetic Resonance ◽  
Brown Adipose Tissue ◽  
Functional Morphology ◽  
Resonance Imaging ◽  
Brown Adipose

scholarly journals Targeted Molecular Magnetic Resonance Imaging Detects Brown Adipose Tissue with Ultrasmall Superparamagnetic Iron Oxide

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Qingqiao Hu ◽  
Xiangxun Chen ◽  
Juan Liu ◽  
Wenjuan Di ◽  
Shan Lv ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Adipose Tissue ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Brown Adipose Tissue ◽  
Superparamagnetic Iron Oxide ◽  
Resonance Imaging ◽  
Ultrasmall Superparamagnetic Iron Oxide ◽  
Brown Adipose

The peptide (CKGGRAKDC-NH2) specifically targets the brown adipose tissue (BAT). Here we applied this peptide coupled with polyethylene glycol (PEG)-coated ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to detect BAT in vivo by magnetic resonance imaging (MRI). The peptide was conjugated with PEG-coated USPIO nanoparticles to obtain targeted USPIO nanoprobes. Then the nanoprobes for BAT were evaluated in mice. T2⁎-weighted images were performed, precontrast and postcontrast USPIO nanoparticles. Finally, histological analyses proved the specific targeting. The specificity of targeted USPIO nanoprobes was observed in mice. The T2⁎ relaxation time of BAT in the targeted group decreased obviously compared to the controls (P<0.001). Prussian blue staining and transmission electron microscope confirmed the specific presence of iron oxide. This study demonstrated that peptide (CKGGRAKDC-NH2) coupled with PEG-coated USPIO nanoparticles could identify BAT noninvasively in vivo with MRI.

scholarly journals Anatomical and Functional Assessment of Brown Adipose Tissue by Magnetic Resonance Imaging

Obesity ◽  
2012 ◽  
Vol 20 (7) ◽  
pp. 1519-1526 ◽  
Author(s):  
Y. Iris Chen ◽  
Aaron M. Cypess ◽  
Christina A. Sass ◽  
Anna-Liisa Brownell ◽  
Kimmo T. Jokivarsi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Adipose Tissue ◽  
Magnetic Resonance ◽  
Brown Adipose Tissue ◽  
Functional Assessment ◽  
Resonance Imaging ◽  
Brown Adipose

scholarly journals Exploring the Effects of Exercise on Brown Adipose Tissue Volumes and T2 Values Using Magnetic Resonance Imaging at 7 Tesla

2021 ◽  
Author(s):  
Yan Zeng ◽  
Lei Gao ◽  
Shuying Shao ◽  
Xiaoshuai Chen ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Adipose Tissue ◽  
Magnetic Resonance ◽  
Brown Adipose Tissue ◽  
7 Tesla ◽  
Control Group ◽  
Resonance Imaging ◽  
Control Groups ◽  
Brown Adipose ◽  
And Control

Abstract Rationale and Objectives: We aimed to evaluate the effect of exercise on brown adipose tissue (BAT) volumes and T2 values in mice. Materials and Methods Twenty-five female Kunming mice were divided into two groups, a running group (n = 5) and a control group (n = 20). After 4 months, all magnetic resonance imaging (MRI) scans of mice were performed on a 7 Tesla (7T) MR scanner with T2-weighted imaging (T2WI) and a T2 mapping sequence. Interscapular brown adipose tissue (BAT) volumes and T2 values were measured. To reduce the impact of weight on the results, we compared the ratio of BAT volumes to body weights (V/W). The data are expressed as mean ± SD, the BAT V/W and T2 values were compared between the control and running groups using the Wilcoxon rank-sum test, P < 0.05 were considered statistically significant. Results Interscapular BAT volumes of the running group (n = 5) and control group (n = 20) were (180.09ml ± 59.80 ml) and (99.98ml ± 35.05ml), respectively. The V/W ratios of the running and control groups were (3.83ml/g ± 0.78ml/g) and (2.17ml/g ± 0.56ml/g), respectively. Interscapular BAT T2 values of the running and control groups were (76.07ms ± 10.82ms) and (61.22ms ± 15.98ms), respectively. Significant differences were found in the BAT V/W ratios (P = 0.0003, P < 0.001) and T2 values between the two groups (P = 0.0096, P < 0.05). BAT volume correlated positively with BAT T2 value (r = 0.75, p = 0.00002). Conclusions MRI is a non-invasive and quantitative method for identifying BAT, especially at ultra-high field like 7T. Long-term running increases BAT volume and T2 value, what's more, BAT volume correlates positively with BAT T2 value.

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